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Bexlosteride (Synonyms: LY300502)

Cat. No.: HY-118091A
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Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer.

For research use only. We do not sell to patients.

Bexlosteride Chemical Structure

Bexlosteride Chemical Structure

CAS No. : 148905-78-6

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Description

Bexlosteride (LY300502) is a benzoquinolinone human type I 5α-reductase inhibitor. Bexlosteride shows metabolic inhibitory, antiproliferative, and antisecretory effects in LNCaP human prostatic adenocarcinoma cell cultures. Bexlosteride can be used for the research of prostatic cancer[1][2].

IC50 & Target

human type I 5α-reductase[1]

In Vitro

Bexlosteride concentration-dependently inhibits reductive metabolism of [3H-T] in the LNCaP cells, with an IC50 of 5.77 nM[1].
Bexlosteride significantly antagonizes Testosterone-induced stimulation of LNCaP cellular proliferation at concentrations greater than 10 nM, and at 1000 nM completely blocks the mitogenic effects of Testosterone on LNCaP cells[1].
Bexlosteride significantly antagonizes Testosterone -induced PSA secretion at a concentration equal to or greater than 30 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

249.74

Formula

C₁₄H₁₆ClNO

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Bexlosteride
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HY-118091A
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