2. PROTAC Vitamin D Related/Nuclear Receptor
  3. PROTACs Estrogen Receptor/ERR
  4. His-TERRα

His-TERRα is a ERRα PROTAC degrader. His-TERRα uses a single amino acid (His) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, and thus is called a mini-PROTAC. His-TERRα significantly inhibits the proliferation and migration of MCF7 breast cancer cells. His-TERRα can be used for the study of breast cancer.
(Pink: ERRα Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-N0832); Black: linker).

For research use only. We do not sell to patients.

His-TERRα

His-TERRα Chemical Structure

CAS No. : 2408835-49-2

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His-TERRα Related Antibodies

Top Publications Citing Use of Products

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

His-TERRα is a ERRα PROTAC degrader. His-TERRα uses a single amino acid (His) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, and thus is called a mini-PROTAC. His-TERRα significantly inhibits the proliferation and migration of MCF7 breast cancer cells. His-TERRα can be used for the study of breast cancer[1]. (Pink: ERRα Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-N0832); Black: linker).

IC50 & Target[1]

ERRα

 

Molecular Weight

695.67

Formula

C31H28F3N9O5S
CAS No.
SMILES

FC(F)(F)C(C=C(C=C1)C#N)=C1OC2=C(C=C(C=C2)/C=C3C(N(C(S\3)=O)CC4=CN(N=N4)CCCNC([C@@H](N)CC5=CN=CN5)=O)=O)OC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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His-TERRα Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

His-TERRα2408835-49-2PROTACsEstrogen Receptor/ERRPROTACN-end rule pathwayDegronmini-PROTACLinker-freeAmino acidsUbiquitin ligaseInhibitorinhibitorinhibit

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