His-TERRα
His-TERRα is a ERRα PROTAC degrader. His-TERRα uses a single amino acid (His) as the E3 ligand and employs the N-end rule pathway to induce the degradation of the target protein, significantly reducing the molecular size, and thus is called a mini-PROTAC. His-TERRα significantly inhibits the proliferation and migration of MCF7 breast cancer cells. His-TERRα can be used for the study of breast cancer.
(Pink: ERRα Target protein ligand; Blue: Ligands for E3 Ligase ligand (HY-N0832); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2408835-49-2
- Formula: C31H28F3N9O5S
- Molecular Weight:695.67
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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ERRα |
Chemical Information
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CAS No. 2408835-49-2
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Molecular Weight 695.67
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Formula C31H28F3N9O5S
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SMILES
FC(F)(F)C(C=C(C=C1)C#N)=C1OC2=C(C=C(C=C2)/C=C3C(N(C(S\3)=O)CC4=CN(N=N4)CCCNC([C@@H](N)CC5=CN=CN5)=O)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
His-TERRα Related Classifications
HY-180961 Related Classifications
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