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peptidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dipeptidyl Peptidase (123) Kallikrein (3) ADC Linker (1) Amino Acid Derivatives (3) Aminopeptidase (7) AMPK (2) Angiotensin-converting Enzyme (ACE) (3) Antibiotic (9) Apoptosis (16) Aryl Hydrocarbon Receptor (1) Autophagy (1) Bacterial (20) Biochemical Assay Reagents (20) Carbonic Anhydrase (1) Carboxypeptidase (2) Cathepsin (4) CD74 (1) ClpP (2) COX (1) Cytochrome P450 (1) Deubiquitinase (10) DNA Alkylator/Crosslinker (2) Drug Intermediate (4) Drug Isomer (2) E1/E2/E3 Enzyme (1) Elastase (3) Endogenous Metabolite (5) Estrogen Receptor/ERR (1) FAP (2) Ferroptosis (7) Fluorescent Dye (4) FXR (1) GCGR (3) GLP Receptor (4) Glutathione Peroxidase (2) Glycosidase (3) GPR119 (3) GSK-3 (1) HIV (3) Insulin Receptor (2) Interleukin Related (4) Isotope-Labeled Compounds (9) JNK (2) Keap1-Nrf2 (1) Lipoxygenase (1) MetAP (1) mGluR (2) Mitophagy (1) MMP (6) Neprilysin (1) NF-κB (2) NOD-like Receptor (NLR) (3) Nuclear Hormone Receptor 4A/NR4A (1) Opioid Receptor (1) P-glycoprotein (2) p38 MAPK (2) Phospholipase (1) Potassium Channel (1) PPAR (1) Proteasome (2) Pyroptosis (1) Reactive Oxygen Species (ROS) (3) Reference Standards (17) SARS-CoV (1) Ser/Thr Protease (7) Small Interfering RNA (siRNA) (1) TNF Receptor (4) Toll-like Receptor (TLR) (1) Transmembrane Glycoprotein (1) VISTA (1) β-catenin (1) γ-secretase (1)
By Research Areas:	Cancer (41) Cardiovascular Disease (17) Endocrinology (3) Infection (23) Inflammation/Immunology (32) Metabolic Disease (99) Neurological Disease (17)
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242

Inhibitors & Agonists

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Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Targets Recommended: Dipeptidyl Peptidase Kallikrein

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-E70005B

Collagenase, Type II 10+ Cited Publications	MMP	Others
Collagenase, Type II is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type II breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-E70005D

Collagenase IV, Clostridium histolytica 10+ Cited Publications Collagenase, Type IV	MMP	Others
Collagenase, Type IV (EC 3.4.24.3) is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type IV degrades type IV collagen and type VII collagen, the main components of the basement membrane, and can also decompose basement matrix and elastin.

HY-E70005A

Collagenase, Type I 15+ Cited Publications EC 3.4.24.3	MMP	Others
Collagenase, Type I is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type I breaks down collagens 1, 3, 7, 8, 10, gelatin, proteoglycans, aggrecan .

HY-E70005C

Collagenase, Type III	MMP	Others
Collagenase, Type III is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type III breaksdown collagens1, 4, 9, 10, 14, fibronectin, MMP-9, gelatin, plasminogen, aggrecan,perlecan osteonectin

HY-14291

Vildagliptin 5 Publications Verification LAF237; NVP-LAF 237	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-111174

Diprotin A 4 Publications Verification Ile-Pro-Ile	Dipeptidyl Peptidase	Metabolic Disease
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) .

HY-10285

Saxagliptin 5+ Cited Publications BMS-477118	Dipeptidyl Peptidase	Metabolic Disease
Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .

HY-A0299

H-Gly-Pro-Hyp-OH Tripeptide 29	MMP	Inflammation/Immunology
H-Gly-Pro-Hyp-OH is a collagen-derived peptide and also a dipeptidyl peptidase-4 inhibitor.\nH-Gly-Pro-Hyp-OH inhibits the activity of dipeptidyl peptidase-4 in vitro. H-Gly-Pro-Hyp-OH binds to the DNA-binding site of the JUN/FOS complex, blocks the formation of the DNA-JUN/FOS complex, and inhibits transcriptional activity. H-Gly-Pro-Hyp-OH is applicable to research related to skin photoaging, UVB-induced skin aging/photoaging, and thrombosis .

HY-E70005E

Collagenase, Type V 1 Publications Verification	MMP	Others
Collagenase, Type V is a microbially derived matrix metalloproteinases (MMPs) and zinc peptidase. Collagenase, Type V breaksdown collagens1, 3, 5, 7, 8, 10, fibronectin, gelatin, aggrecann .

HY-P1141

GLP-1(9-36)amide	GCGR	Metabolic Disease
GLP-1(9-36)amide is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide acts as an antagonist to the human pancreatic GLP-1 receptor .

HY-14892A

Gemigliptin tartrate LC15-0444 tartrate	Dipeptidyl Peptidase	Metabolic Disease
Gemigliptin tartrate (LC15-0444 tartrate) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin tartrate exhibits potent anti-glycation properties. Gemigliptin tartrate can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-W009004

Trilysine Lys-Lys-Lys; H-Lys-Lys-Lys-OH	Biochemical Assay Reagents	Others
Trilysine is a tripeptide and also a substrate for specific peptidases. Trilysine serves as a hydrolytic substrate for the tripeptide-specific aminopeptidase TP and the oligopeptidase OP .

HY-112668A

Retagliptin 1 Publications Verification SP2086	Dipeptidyl Peptidase	Metabolic Disease
Retagliptin (SP2086) is a selective, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* inhibitor. Retagliptin can be used for type 2 diabetes mellitus (T2DM) research .

HY-P2233

Globomycin	Bacterial Antibiotic	Infection
Globomycin is a lipopeptide antibiotic and a *signal peptidase* II (LspA)** inhibitor. Globomycin inhibits processing of the prolipoprotein by binding irreversibly to the peptidase. Globomycin has toxic for the mollicute *Spiroplasma melliferum* with a MIC in the range 6.25-12.5 μM .

HY-18522

AA26-9	Phospholipase	Metabolic Disease
AA26-9 is a potent and broad spectrum serine hydrolase inhibitor. AA26-9 targets included serine peptidases, lipases, amidases, esterases, and thioesterases. AA26-9 shows inhibitory activity against approximately 1/3 of the 40+ serine hydrolases detected in immortalized T cell lines .

HY-112668

Retagliptin phosphate 1 Publications Verification SP2086 phosphate	Dipeptidyl Peptidase	Metabolic Disease
Retagliptin phosphate (SP2086 phosphate) is a selective, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* inhibitor. Retagliptin phosphate can be used for type 2 diabetes mellitus (T2DM) research .

HY-16448

Saxagliptin hydrochloride 5+ Cited Publications BMS-477118 hydrochloride	Dipeptidyl Peptidase	Metabolic Disease
Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research .

HY-10286

Dutogliptin PHX-1149 free base	Dipeptidyl Peptidase	Metabolic Disease
Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.

HY-10287

Gosogliptin 1 Publications Verification PF-00734200; PF-734200	Dipeptidyl Peptidase	Metabolic Disease
Gosogliptin is a potent and selective inhibitor of dipeptidyl peptidase-IV (DPP-IV).

HY-110083

PK44 phosphate	Dipeptidyl Peptidase	Metabolic Disease
PK44 phosphate is a potent *dipeptidyl peptidase* IV (DPP-IV) inhibitor with an IC₅₀** value of 15.8 nM .

HY-10285A

Saxagliptin hydrate 5+ Cited Publications BMS-477118 hydrate	Dipeptidyl Peptidase	Metabolic Disease
Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin hydrate has the peotential for type 2 diabetes mellitus research .

HY-101769

UAMC00039 dihydrochloride 1 Publications Verification	Dipeptidyl Peptidase	Cancer
UAMC00039 dihydrochloride is a potent, reversible and competitive *dipeptidyl peptidase* II inhibitor with an IC₅₀** of 0.48 nM.

HY-14892

Gemigliptin LC15-0444	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin (LC15-0444 ) is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin exhibits potent anti-glycation properties. Gemigliptin can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-E70397A

*Dipeptidyl Peptidase* IV, Porcine Kidney** DPP-IV, Porcine Kidney	Dipeptidyl Peptidase	Metabolic Disease
Dipeptidyl Peptidase IV, Porcine Kidney (DPP-IV, Porcine Kidney) is a serine aminopeptidase with multiple physiological roles. Dipeptidyl Peptidase IV, Porcine Kidney hydrolyses gastric inhibitory peptide (GIP) and glucagon-like peptide 1 (GLP-1), the most important insulin-releasing hormones (incretins) of the enteroinsular axis .

HY-P4920

Mca-SEVNLDAEFK(Dnp)-NH2	Fluorescent Dye	Others
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1 .

HY-P4460

AAA-pNA	Ser/Thr Protease	Cancer
AAA-pNA is a chromogenic substrate of *Tripeptidyl-peptidase* II*. AAA-pNA can be used to test Tripeptidyl-peptidase* II activity .

HY-148190

Sheng Gelieting CGT-8012	Dipeptidyl Peptidase	Endocrinology
Sheng Gelieting (CGT-8012) is a *dipeptidy peptidase-IV enzyme (DP-IV)* inhibitor. Sheng Gelieting has great DP-IV inhibition activity with an IC₅₀ value of 87 nM. Sheng Gelieting can be used for curing or preventing diseases relevant to the dipeptidy peptidase-IV enzyme, such as the diabetes, particularly the II-type diabete .

HY-P1141A

GLP-1(9-36)amide TFA	GCGR	Metabolic Disease
GLP-1(9-36)amide TFA is a major metabolite of glucagon-like peptide-1-(7-36) amide formed by the enzyme dipeptidyl peptidase-4 (DPP-4). GLP-1(9-36)amide TFA acts as an antagonist to the human pancreatic GLP-1 receptor .

HY-150070

Butabindide UCL-1397	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) is a potent, selective *tripeptidvl peptidase* II (TPP II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .

HY-107759

Butabindide oxalate 2 Publications Verification UCL-1397 oxalate	Ser/Thr Protease	Neurological Disease
Butabindide (UCL-1397) oxalate is a potent, selective *tripeptidvl peptidase* II (TPP II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .

HY-151871

ICeD-2	Dipeptidyl Peptidase HIV	Infection
ICeD-2 is a inducer of cell death, can induce HIV-1 infected cell kill. ICeD-2-mediated HIV-1 infected cell kill is dependent on HIV-1 protease activity. ICeD-2 potently blocks hydrolysis of Gly-Pro-AMC by *dipeptidyl peptidase* DPP8 and DPP9**. ICeD-2 shows strong stabilization of DPP9 in PBMCs .

HY-139440

DL-Leucyl-DL-phenylalanine	Biochemical Assay Reagents	Others
DL-Leucyl-DL-phenylalanine is a dipeptide and can be used as a substrate to detecte two regions of dipeptidase staining on a gel in Drosophila simulans as well as in Drosophila melanogaster .

HY-P4363

Suc-GPLGP-AMC	Biochemical Assay Reagents	Others
Suc-GPLGP-AMC is a peptide substrate of collagenase-like peptidases .

HY-P4468

Lys-Ala-pNA	Dipeptidyl Peptidase	Others
Lys-Ala-pNA is hydrolytic substrate the of dipeptidyl peptidase (DPP) II with K_m of 0.42 mM .

HY-N6584

Saikogenin A 1 Publications Verification	Dipeptidyl Peptidase	Metabolic Disease Inflammation/Immunology
Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

HY-12733

AZD5248	Dipeptidyl Peptidase	Inflammation/Immunology
AZD5248 is a dipeptidyl peptidase 1 (DPP1) inhibitor that can be used for the research of chronic obstructive lung disease .

HY-P4464

Ala-Phe-Pro-pNA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA can be used to test tripeptidyl peptidase activity .

HY-P4464A

Ala-Phe-Pro-pNA TFA	Ser/Thr Protease	Cancer
Ala-Phe-Pro-pNA TFA is a chromogenic substrate of tripeptidyl peptidase. Ala-Phe-Pro-pNA TFA can be used to test tripeptidyl peptidase activity .

HY-P4470

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-W003592A

L-Orinithine lactam hydrochloride	Drug Intermediate	Others
L-Orinithine lactam hydrochloride is a synthetic intermediate. L-Orinithine lactam (hydrochloride) can be used in the synthesis of dipeptidyl peptidase 4 (DPP-4) inhibitors, as well as signaling peptides .

HY-129736A

P32/98	Dipeptidyl Peptidase	Metabolic Disease
P32/98 a potent inhibitor of *dipeptidyl peptidase* IV** with a K_i value of 130 nM. P32/98 improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model .

HY-14292

NVP-DPP728	Dipeptidyl Peptidase	Metabolic Disease
NVP-DPP728 is a potent, reversible and nitrile-dependent *dipeptidyl peptidase* IV (DPP-IV) inhibitor. NVP-DPP728 can inhibit human DPP-IV amidolytic activity with a K_i** of 11 nM. NVP-DPP728 inhibits degradation of glucagon-like peptide-1 (GLP-1) and thereby potentiates insulin release in response to glucose intake. NVP-DPP728 can be used for researching diabetes .

HY-111174A

Diprotin A TFA 4 Publications Verification Ile-Pro-Ile TFA	Dipeptidyl Peptidase	Metabolic Disease
Diprotin A TFA (Ile-Pro-Ile TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) .

HY-E70018

Picornain 3C	Endogenous Metabolite	Infection Metabolic Disease
Picornain 3C is a protease found in picornaviruses, which cleaves peptide bonds of non-terminal sequences. Picornain 3C is an intermediate between the serine peptidase chymotrypsin and the cysteine peptidase papain. Picornain 3C shows endopeptidase activity by selectively cleaving Gln-Gly bonds in the polyprotein of poliovirus and with substitution of Glu for Gln, and Ser or Thr for Gly in other picornaviruses .

HY-14892C

Gemigliptin hydrochloride LC15-0444 hydrochloride	Dipeptidyl Peptidase	Metabolic Disease Cancer
Gemigliptin hydrochloride is the hydrochloride salt of Gemigliptin (HY-14892). Gemigliptin hydrochloride is a highly selective, reversible and competitive dipeptidyl peptidase-4 (DPP-4) inhibitor, with an IC₅₀ of 10.3 nM for human recombinant DPP-4. Gemigliptin hydrochloride exhibits potent anti-glycation properties. Gemigliptin hydrochloride can be used for the research of advanced glycation end products (AGE)-related diabetic complications .

HY-131250

N-Boc-Sitagliptin	Dipeptidyl Peptidase	Metabolic Disease
N-Boc-Sitagliptin is an intermediate in the synthesis of the dipeptidyl peptidase 4 (DPP-4) inhibitor Sitagliptin (HY-13749).

HY-W764737

Methylboronic acid pinacol ester-d3	Isotope-Labeled Compounds	Cancer
Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .

HY-14291A

Vildagliptin dihydrate LAF237 dihydrate; NVP-LAF 237 dihydrate	Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease Cancer
Vildagliptin dihydrate (LAF237 dihydrate) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin dihydrate possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291R

Vildagliptin (Standard) LAF237 (Standard); NVP-LAF 237 (Standard)	Reference Standards Dipeptidyl Peptidase Ferroptosis Apoptosis	Metabolic Disease
Vildagliptin (Standard) is the analytical standard of Vildagliptin. This product is intended for research and analytical applications. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S2

Vildagliptin-13C5,15N LAF237-¹³C₅,¹⁵N; NVP-LAF 237-¹³C₅,¹⁵N	Isotope-Labeled Compounds Dipeptidyl Peptidase Apoptosis Ferroptosis	Metabolic Disease
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

Cat. No.	Nombre del producto	Category	Target	Chemical Structure

HY-P1645

Papain Maximum Cited Publications 15 Publications Verification	Carica papaya L. Structural Classification Productos naturales Classification of Application Fields Caricaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	Cathepsin
Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .

HY-111174

Diprotin A 4 Publications Verification Ile-Pro-Ile	Microorganisms Source Classification	Dipeptidyl Peptidase
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV) .

HY-P1645A

Papain (1.5-10 units/mg)	Carica papaya L. Structural Classification Productos naturales Caricaceae Plants Source Classification	Cathepsin
Papain (1.5-10 units/mg) is a cysteine protease of the peptidase C1 family. Papain (1.5-10 units/mg) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (1.5-10 units/mg) can induce pulmonary emphysema. Papain (1.5-10 units/mg) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .

HY-N6079

Timosaponin A1	Liliaceae Classification of Application Fields Other Diseases Anemarrhena asphodeloides Bunge Plants Disease Research Fields Steroids Source Classification	Lipoxygenase Dipeptidyl Peptidase COX
Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and *dipeptidyl peptidase* 4 (DPP-4) inhibitor with IC₅₀**s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively .

HY-N7653

Azaleatin	Flavonols Flavonoids Classification of Application Fields Carthamus tinctorius L. Phenols Polyphenols Metabolic Disease Plants Compositae Disease Research Fields Source Classification	Dipeptidyl Peptidase
Azaleatin is an O-methylated flavonol isolated from Rhododendron species. Azaleatin is a dipeptidyl peptidase-IV inhibitor. Azaleatin can be used for the research of type-2 diabetes and obesity .

HY-N6584

Saikogenin A 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Plants Disease Research Fields Inflammation/Immunology Source Classification	Dipeptidyl Peptidase
Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

HY-P10809

VAMP	Structural Classification Cannabis sativa L Ketones, Aldehydes, Acids Plants Moraceae Source Classification	Dipeptidyl Peptidase
VAMP, a tetrapeptide, is a competitive *dipeptidyl peptidase* IV (DPP-IV) inhibitor with an IC₅₀ of 1.00 μM and a K_d** of 6.89 μM. VAMP effectively targets the DPP-IV-GLP-1 axis and can be used for the study of type 2 diabetes .

HY-N8134

2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one	Productos naturales other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Dipeptidyl Peptidase
2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one is a natural product found in the leaves and stem bark of M. glabra. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one displays binding affinities with *dipeptidyl peptidase-4 (DPP-4)* and α-Amylase. 2-Methoxy-5-acetoxy-fruranogermacr-1(10)-en-6-one has potential antidiabetic activities .

HY-N10362

Ellipyrone B	Classification of Application Fields Animals Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Source Classification	Dipeptidyl Peptidase
Ellipyrone B, an antihyperglycemic γ-pyrone enclosed macrocyclic polyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.48 mM) .

HY-N15105

Acetyl-L-Ieucyl-L-argininal	Productos naturales Microorganisms Source Classification	Dipeptidyl Peptidase
Acetyl-L-Ieucyl-L-argininal shows inhibition of peptidyl amin-peptidase III activity .

HY-113015R

Stearoylethanolamide (Standard)	Productos naturales Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Saxagliptin (hydrochloride) (Standard) is the analytical standard of Saxagliptin (hydrochloride). This product is intended for research and analytical applications. Saxagliptin hydrochloride (BMS-477118 hydrochloride) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrochloride has the peotential for type 2 diabetes mellitus research .

HY-N10360

Ellipyrone A	Classification of Application Fields Animals Ketones, Aldehydes, Acids Metabolic Disease Disease Research Fields Source Classification	Dipeptidyl Peptidase
Ellipyrone A, a γ-pyrone enclosed macrocyclic poyketide, shows inhibition potential against dipeptidyl peptidase-4 (IC₅₀=0.35 mM). Ellipyrone A also has anti-carbolytic property against α-glucosidase (IC₅₀=0.74 mM) and α-amylase (IC₅₀=0.59 mM) .

HY-155704

Lyciumamide A	Lycium barbarum L. Phenols Polyphenols Solanaceae Plants Source Classification	PPAR
DPP-IV-IN-5 is isolated from the fruits of Lycium barbarum. DPP-IV-IN-5 exerts moderate agonistic activities for peroxisome proliferator-activated receptor (PPARγ) with EC₅₀ values of 10.09 - 44.26 μM and also presents inhibitory activity on dipeptidyl peptidase-4 (DPPIV) with an IC₅₀ value of 47.13 μM .

HY-N15181

Fluostatin B	Monophenols Microorganisms Phenols Source Classification	Dipeptidyl Peptidase
Fluostatin B is a dipeptidyl peptidase 3 (DPP-3) inhibitor with an IC₅₀ value of 24 µg/mL. Fluostatin B is a fluorenone, which is found in Streptomyces .

HY-N13981

Arylomycin B2	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Bacterial
Arylomycin B2, an antibiotic, is a potent *signal peptidase* I (SPase I)** inhibitor. Arylomycin B2 has anti-Gram-positive bacteria activities .

HY-111174R

Diprotin A (Standard) Ile-Pro-Ile (Standard)	Microorganisms Source Classification	Reference Standards Dipeptidyl Peptidase
Diprotin A (Standard) is the analytical standard of Diprotin A. This product is intended for research and analytical applications. Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].

HY-N4069

Lupinalbin A Boeravinone L	Flavonoids Leguminosae Plants Other Flavonoids Lupinus albus Linn. Source Classification	Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Dipeptidyl Peptidase Glycosidase
Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and α-glucosidase inhibitor with IC₅₀ values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity .

HY-N10064

Ficusonolide	Triterpenes other families Classification of Application Fields Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Others
Ficusonolide has significant antidiabetic activity with a possible mechanism of interaction with dipeptidyl peptidase-IV (DPP-IV), protein tyrosine phosphatase 1B (PTP-1B), α-glucosidase, and α-amylase.

HY-N12043

Bidenoside C	Coreopsis lanceolata L. Plants Compositae Saccharides Monosaccharides Source Classification	Others
Bidenoside C (compound 10) is a polyacetylene glycoside (Polyacetylene Glycoside), which can be isolated from the flowers of Coreopsis lanceolata (Asteraceae) .

HY-N17532

(Rac)-Regaloside D	Structural Classification Monophenols Liliaceae Lilium longiflorum Thunb. Phenols Plants Source Classification	Dipeptidyl Peptidase
(Rac)-Regaloside D is a phenylpropanoid. (Rac)-Regaloside D can be found in the scaly bulbs of Lilium longiflorum. (Rac)-Regaloside D does not exhibit dipeptidyl peptidase IV (DPP-IV) inhibitory activity in vitro .

Cat. No.	Nombre del producto	Chemical Structure

HY-W764737

Methylboronic acid pinacol ester-d3
Methylboronic acid pinacol ester is an orally administered compound that inhibits the activity of peptidases and imidazole derivatives. Methylboronic acid pinacol ester is used as a medicinal preparation for cancer .

HY-14291S2

Vildagliptin-13C5,15N
Vildagliptin- ¹³C₅, ¹⁵N (LAF237- ¹³C₅, ¹⁵N; NVP-LAF 237- ¹³C₅, ¹⁵N) is a ¹³C- and ¹⁵N-labeled Vildagliptin (HY-14291). Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S1

Vildagliptin-d7
Vildagliptin-d₇ is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14291S

Vildagliptin-d3
Vildagliptin-d₃ is the deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-10285S2

Saxagliptin-13C2
Saxagliptin- ¹³C₂ (BMS-477118- ¹³C₂) is ¹³C labeled Saxagliptin. Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .

HY-10285S

Saxagliptin-15N,d2 hydrochloride
Saxagliptin-15N,d2 Hydrochloride (BMS-477118-15N,d2 Hydrochloride) is the ¹⁵N and deuterium labeled isotope of Saxagliptin (HY-10285). Saxagliptin (BMS-477118) is a potent, selective, reversible, competitive and orally active *dipeptidyl peptidase-4 (DPP-4)* (K_i = 0.6-1.3 nM) inhibitor. Saxagliptin has the peotential for type 2 diabetes mellitus research .

HY-161447

USP1-IN-8
USP1-IN-8 (Compound 16) is an inhibitor for ubiquitin specific peptidase 1 (USP1) and its cofactor UAF1, with IC₅₀ ≤50 nM. USP1-IN-8 inhibits proliferation of MDA-MB-436 with IC₅₀ ≤50 nM .

HY-14291S5

Vildagliptin-d6
Vildagliptin-d₆ (LAF237-d₆ ) is deuterium labeled Vildagliptin. Vildagliptin (LAF237) is a potent, stable, selective dipeptidyl peptidase IV (DPP-IV) inhibitor with an IC₅₀ of 3.5 nM in human Caco-2 cells. Vildagliptin possesses excellent oral bioavailability and potent antihyperglycemic activity .

HY-14877S1

Anagliptin-d7
Anagliptin-d₇ (SK-0403-d₇) is deuterium labeled Anagliptin. Anagliptin (SK-0403) is a highly selective, potent, orally active inhibitor of *dipeptidyl peptidase* 4 (DPP-4), with an IC₅₀ of 3.8 nM, and less selective at DPP-8 and DDP-9 with IC₅₀**s of 68 nM and 60 nM, respectively .

HY-14806S2

Teneligliptin-d5

Teneligliptin-d₅ (MP-513-d₅) is deuterium labeled Teneligliptin. Teneligliptin (MP-513) hydrobromide hydrate is an orally active and selective dipeptidyl peptidase 4 (DPP-4) inhibitor (IC₅₀s: 0.37 and 0.29 nM for the human and rat DPP-4, respectively). Teneligliptin hydrobromide hydrate improves blood glucose levels and can be used in researches related to type 2 diabetes mellitus .

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