Serpin B2 Protein, Human (HEK293, His)
Based on 1 Customer Validation
Serpin B2 inhibits urokinase-type plasminogen activator and contributes to fibrinolytic regulation. Monocyte-derived plasminogen activator inhibitor 2 (PAI-2) differs from endothelial cell-derived PAI-1, highlighting different cellular origins. Serpin B2, Human (HEK293, His) is the recombinant human-derived Serpin B2 protein, expressed by HEK293, with labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
Serpin B2 inhibits urokinase-type plasminogen activator and contributes to fibrinolytic regulation. Monocyte-derived plasminogen activator inhibitor 2 (PAI-2) differs from endothelial cell-derived PAI-1, highlighting different cellular origins. Serpin B2, Human (HEK293, His) is the recombinant human-derived Serpin B2 protein, expressed by HEK293, with labeled tag.
Background
Serpin B2 functions as an inhibitor of urokinase-type plasminogen activator, contributing to the regulation of fibrinolysis. Notably, the monocyte-derived form of plasminogen activator inhibitor-2 (PAI-2) differs from the endothelial cell-derived PAI-1, emphasizing the diverse cellular origins and roles within the intricate network of protease regulation. Serpin B2 is intricately involved in modulating the activity of urokinase-type plasminogen activator, reflecting its significance in the dynamic interplay of proteolytic processes. Additionally, Serpin B2 engages in interactions with PSMB1, possibly participating in complex cellular pathways that extend beyond its classical role as a plasminogen activator inhibitor.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-10*His
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Accession
P05120 (M1-P415)
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Gene ID5055
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Protein Length
Full Length
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Synonyms
SERPINB2; Placental Plasminogen Activator Inhibitor; Prev. PLANH2; Plasminogen-Activator Inhibitor; Prev. PAI2; Monocyte Arg-Serpin; PAI-2; Urokinase Inhibitor; HsT1201; Serpin B2; Serine (Or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2;
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AA Sequence
MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYMGSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADKIHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLECAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNGLYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVSTGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFNKGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADHPFLFLIMHKITNCILFFGRFSSP
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Predicted Molecular Mass
50.1 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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