AX8819
AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC50 of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 928161-33-5
- 分子式: C11H21N3O
- 分子量:211.30
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
DPP-2 0.88 nM (IC50) |
体外実験
AX8819 potently and selectively inhibits purified DPP II with an IC50 of 0.88 nM, with no measurable activity against other tested DPP family enzymes[1].
AX8819 (0.88-44 μM) inhibits overexpressed DPP II activity in DPP II-293T HEK cells at all tested concentrations, inhibits endogenous DPP II activity in Jurkat cells at 4.4-44 μM[1].
AX8819 (0-44 μM; 16 h) exhibits very low non-specific cytotoxicity toward proliferating Jurkat cells at concentrations up to 44 μM[1].
AX8819 (4.4-44 μM; 4-16 h) induces apaptosis in resting PBMCs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:resting PBMCs
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Concentration:4.4, 8.8, 22, 44 μM
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Incubation Time:4, 8, 16 h
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Result:Induces apaptosis in a time- and concentration-dependent manner.
化学情報
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CAS 番号 928161-33-5
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分子量 211.30
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分子式 C11H21N3O
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SMILES
NCC[C@H](N)C(N1[C@@]2([H])[C@@](CCC2)([H])CC1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AX8819 関連分類
HY-182374 関連分類
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