2. Metabolic Enzyme/Protease Apoptosis
  3. Dipeptidyl Peptidase Apoptosis
  4. AX8819

AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC50 of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia.

For research use only. We do not sell to patients.

AX8819

AX8819 Chemical Structure

CAS No. : 928161-33-5

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AX8819 Related Antibodies

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

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Description

AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC50 of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia[1].

IC50 & Target[1]

DPP-2

0.88 nM (IC50)

In Vitro

AX8819 potently and selectively inhibits purified DPP II with an IC50 of 0.88 nM, with no measurable activity against other tested DPP family enzymes[1].
AX8819 (0.88-44 μM) inhibits overexpressed DPP II activity in DPP II-293T HEK cells at all tested concentrations, inhibits endogenous DPP II activity in Jurkat cells at 4.4-44 μM[1].
AX8819 (0-44 μM; 16 h) exhibits very low non-specific cytotoxicity toward proliferating Jurkat cells at concentrations up to 44 μM[1].
AX8819 (4.4-44 μM; 4-16 h) induces apaptosis in resting PBMCs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AX8819 Related Antibodies

Apoptosis Analysis[1]

Cell Line: resting PBMCs
Concentration: 4.4, 8.8, 22, 44 μM
Incubation Time: 4, 8, 16 h
Result: Induces apaptosis in a time- and concentration-dependent manner.
Molecular Weight

211.30

Formula

C11H21N3O
CAS No.
SMILES

NCC[C@H](N)C(N1[C@@]2([H])[C@@](CCC2)([H])CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AX8819 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AX8819928161-33-5AX 8819AX-8819Dipeptidyl PeptidaseApoptosisDPPproliferating T cellshuman peripheral blood mononuclear cellsDPP IIDPP II-293T HEK cellscaspase-dependent apoptosisJurkat cellswild-type HEK 293T cellsdipeptidyl peptidase IIB cell chronic lymphocytic leukemiaInhibitorinhibitorinhibit

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