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Cat. No.: HY-182374

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AX8819

AX8819 is a selective dipeptidyl peptidase II (DPP II) inhibitor with an IC₅₀ of 0.88 nM. AX8819 induces caspase-dependent apoptosis. AX8819 exhibits low non-specific toxicity toward proliferating T cells. AX8819 can be used for the research of B cell chronic lymphocytic leukemia.

For research use only. We do not sell to patients.

CAS No.: 928161-33-5
Formula: C₁₁H₂₁N₃O
Molecular Weight:211.30

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AX8819 Chemical Structure

CAS No.: 928161-33-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

DPP-2

0.88 nM (IC₅₀)

All Dipeptidyl Peptidase Isoforms :

In Vitro

AX8819 potently and selectively inhibits purified DPP II with an IC₅₀ of 0.88 nM, with no measurable activity against other tested DPP family enzymes^[1].
AX8819 (0.88-44 μM) inhibits overexpressed DPP II activity in DPP II-293T HEK cells at all tested concentrations, inhibits endogenous DPP II activity in Jurkat cells at 4.4-44 μM^[1].
AX8819 (0-44 μM; 16 h) exhibits very low non-specific cytotoxicity toward proliferating Jurkat cells at concentrations up to 44 μM^[1].
AX8819 (4.4-44 μM; 4-16 h) induces apaptosis in resting PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

resting PBMCs
Concentration:

4.4, 8.8, 22, 44 μM
Incubation Time:

4, 8, 16 h
Result:

Induces apaptosis in a time- and concentration-dependent manner.

Chemical Information

CAS No. 928161-33-5
Molecular Weight 211.30
Formula C₁₁H₂₁N₃O
SMILES

NCC[C@H](N)C(N1[C@@]2([H])[C@@](CCC2)([H])CC1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Danilova O, et al. Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor. Bioorg Med Chem Lett. 2007;17(2):507-510. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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AX8819

All Dipeptidyl Peptidase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

AX8819 Related Classifications

HY-182374 Related Classifications