Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):507-10. doi: 10.1016/j.bmcl.2006.10.012.
Olga Danilova  1 ,  Bei Li ,  A Katrin Szardenings ,  Brigitte T Huber ,  Jonathan S Rosenblum
Affiliations
  • 1. Tufts University School of Medicine, 150 Harrison Avenue, Boston, MA 02111, USA.
PMID: 17055271 DOI: 10.1016/j.bmcl.2006.10.012
Abstract

A cell permeable DPP II [also known as DPP2, DPP7, and quiescent cell proline dipeptidase (QPP)] inhibitor has been synthesized. The azabicyclo[3.3.0]octane-based inhibitor is potent and selective and elicits very similar quiescent lymphocyte death to previously characterized inhibitors that are not as selective.

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