1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. P32/98 hemifumarate

P32/98 hemifumarate 

Cat. No.: HY-129736
Handling Instructions

P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.

For research use only. We do not sell to patients.

P32/98 hemifumarate Chemical Structure

P32/98 hemifumarate Chemical Structure

CAS No. : 251572-86-8

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Description

P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].

IC50 & Target

DPP-IV

130 nM (Ki)

In Vitro

GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo[2].
P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells[2].
P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[2]

Cell Line: Porcine proximal tubular cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Showed no toxic.
In Vivo

P32/98 hemifumarate (25 mg/kg; i.g.; once daily) long-time treatment significantly improves the glucose tolerance in Zucker diabetic fatty rats, a model of IGT (impaired glucose tolerance)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Zucker diabetic fatty rat[3]
Dosage: 25 mg/kg
Administration: Oral gavage; once daily
Result: Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
Molecular Weight

260.36

Formula

C9H18N2OS.1/2C4H4O4

CAS No.
SMILES

CC[[email protected]](C)[[email protected]](N)C(N1CSCC1)=O.O=C(O)/C=C/C(O)=O.[1/2]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Product Name:
P32/98 hemifumarate
Cat. No.:
HY-129736
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