P32/98 hemifumarate
P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model.
For research use only. We do not sell to patients.
- CAS No.: 251572-86-8
- Formula: C9H18N2OS.1/2C4H4O4
- Molecular Weight:260.36
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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DPP-4 130 nM (Ki) |
GLP-1 acts function of stimulation of glucose dependent insulin secretion and induction of satiety feelings, and DPPIV is the major renal catabolic pathway for GLP-1 in vivo[2].
P32/98 hemifumarate, together with 200 pM GLP-1, (10 μM; 3 h) shows no significant inhibition of sodium re-absorption in porcine proximal tubular cells[2].
P32/98 hemifumarate (10 μM; 96 h) does not influence the mRNA expression of GLP-1R, DPPIV, Na+/H+ exchanger isoform 3 (NHE3), sodium-dependent glucose transporter slc5a1, slc5a2 (SGLT1, 2)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Porcine proximal tubular cells
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Concentration:10 μM
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Incubation Time:96 hours
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Result:Showed no toxic.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Zucker diabetic fatty rat[3]
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Dosage:25 mg/kg
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Administration:Oral gavage; once daily
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Result:Significantly improved the glucose tolerance in Zucker diabetic fatty rats.
Chemical Information
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CAS No. 251572-86-8
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Molecular Weight 260.36
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Formula C9H18N2OS.1/2C4H4O4
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SMILES
CC[C@H](C)[C@H](N)C(N1CSCC1)=O.O=C(O)/C=C/C(O)=O.[1/2]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. [Content Brief]
[2]. Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8. [Content Brief]
[3]. Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P32/98 hemifumarate Related Classifications
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