251572-86-8
251572-86-8
Chemical Structure
P32/98 hemifumarate
- CAS No.: 251572-86-8
- Formula:C9H18N2OS.1/2C4H4O4
- Molecular Weight:260.36
SMILES: CC[C@H](C)[C@H](N)C(N1CSCC1)=O.O=C(O)/C=C/C(O)=O.[1/2]
Biological Activity: P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model[1][2][3].
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P32/98 hemifumarate | P32/98 hemifumarateis a potent inhibitor of dipeptidyl peptidase IV with a Ki value of 130 nM. P32/98 hemifumarate improves glucose tolerance, insulin sensitivity and β-cell responsiveness in fatty Zucker rat model. | |||||||||||||||||||||
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References
- [1]. Augstein P, et al. Efficacy of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidide (P32/98) in fatty Zucker rats with incipient and manifest impaired glucose tolerance. Diabetes Obes Metab. 2008;10(10):850-861. [Content Brief]
- [2]. Schlatter P, et al. Glucagon-like peptide 1 receptor expression in primary porcine proximal tubular cells. Regul Pept. 2007 Jun 7;141(1-3):120-8. [Content Brief]
- [3]. Wargent E, et al. Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone. Diabetes Obes Metab. 2005;7(2):170-181. [Content Brief]
Keywords
