DPP10 Protein, Human (HEK293, His)

The DPP10 protein is a key regulator that promotes cell surface expression of the potassium channel KCND2, modulating its activity and gating properties. Despite its name, DPP10 lacks dipeptidyl aminopeptidase activity. DPP10 Protein, Human (HEK293, His) is the recombinant human-derived DPP10 protein, expressed by HEK293 , with N-His labeled tag.

DPP10 Protein emerges as a key regulator in cellular dynamics by promoting the cell surface expression of the potassium channel KCND2, showcasing its involvement in modulating the activity and gating characteristics of this potassium channel. Contrary to its nomenclature, DPP10 demonstrates no dipeptidyl aminopeptidase activity. This multifaceted protein may form oligomers, indicating potential involvement in complex molecular assemblies. Notably, DPP10 engages in specific interactions with both KCND1 and KCND2, suggesting its active role in the modulation of potassium channel function. The intricate interplay of DPP10 with these channels underscores its significance in shaping cellular excitability and warrants further exploration to unravel the detailed mechanisms governing its regulatory functions in potassium channel dynamics.

Human

HEK293

N-His

Q8N608-1 (L56-E796)

57628  [NCBI]

Extracellular Domain

LTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE

90-110 kDa

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.