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DPP10 Protein, Human (HEK293, His)

The DPP10 protein is a key regulator that promotes cell surface expression of the potassium channel KCND2, modulating its activity and gating properties. Despite its name, DPP10 lacks dipeptidyl aminopeptidase activity. DPP10 Protein, Human (HEK293, His) is the recombinant human-derived DPP10 protein, expressed by HEK293 , with N-His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • DPP10 Protein, Human (HEK293, His) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
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  • Biological Activity
  • Technical Parameters
  • Product Properties
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Biological Activity

Description

The DPP10 protein is a key regulator that promotes cell surface expression of the potassium channel KCND2, modulating its activity and gating properties. Despite its name, DPP10 lacks dipeptidyl aminopeptidase activity. DPP10 Protein, Human (HEK293, His) is the recombinant human-derived DPP10 protein, expressed by HEK293 , with N-His labeled tag.

Background

DPP10 Protein emerges as a key regulator in cellular dynamics by promoting the cell surface expression of the potassium channel KCND2, showcasing its involvement in modulating the activity and gating characteristics of this potassium channel. Contrary to its nomenclature, DPP10 demonstrates no dipeptidyl aminopeptidase activity. This multifaceted protein may form oligomers, indicating potential involvement in complex molecular assemblies. Notably, DPP10 engages in specific interactions with both KCND1 and KCND2, suggesting its active role in the modulation of potassium channel function. The intricate interplay of DPP10 with these channels underscores its significance in shaping cellular excitability and warrants further exploration to unravel the detailed mechanisms governing its regulatory functions in potassium channel dynamics.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag N-His
  • Accession

    Q8N608-1 (L56-E796)

  • Gene ID
    57628  [NCBI]
  • Molecular Construction
    • N-term
    • His
    • DPP10 (L56-E796)
      Accession # Q8N608-1
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    DPP10; DPP X; Dipeptidyl Peptidase Like 10; CDNA FLJ55490, Highly Similar To Inactive Dipeptidyl Peptidase 10; DPRP3; Dipeptidyl-Peptidase 10 (Non-Functional); DPL2; Dipeptidyl-Peptidase 10, Isoform CRA_b; DPPY; Uncharacterized Protein DPP10; Dipeptidyl P

  • AA Sequence

    LTPDELTNSSETRLSLEDLFRKDFVLHDPEARWINDTDVVYKSENGHVIKLNIETNATTLLLENTTFVTFKASRHSVSPDLKYVLLAYDVKQIFHYSYTASYVIYNIHTREVWELNPPEVEDSVLQYAAWGVQGQQLIYIFENNIYYQPDIKSSSLRLTSSGKEEIIFNGIADWLYEEELLHSHIAHWWSPDGERLAFLMINDSLVPTMVIPRFTGALYPKGKQYPYPKAGQVNPTIKLYVVNLYGPTHTLELMPPDSFKSREYYITMVKWVSNTKTVVRWLNRAQNISILTVCETTTGACSKKYEMTSDTWLSQQNEEPVFSRDGSKFFMTVPVKQGGRGEFHHVAMFLIQSKSEQITVRHLTSGNWEVIKILAYDETTQKIYFLSTESSPRGRQLYSASTEGLLNRQCISCNFMKEQCTYFDASFSPMNQHFLLFCEGPRVPVVSLHSTDNPAKYFILESNSMLKEAILKKKIGKPEIKILHIDDYELPLQLSLPKDFMDRNQYALLLIMDEEPGGQLVTDKFHIDWDSVLIDMDNVIVARFDGRGSGFQGLKILQEIHRRLGSVEVKDQITAVKFLLKLPYIDSKRLSIFGKGYGGYIASMILKSDEKLFKCGSVVAPITDLKLYASAFSERYLGMPSKEESTYQAASVLHNVHGLKEENILIIHGTADTKVHFQHSAELIKHLIKAGVNYTMQVYPDEGHNVSEKSKYHLYSTILKFFSDCLKEEISVLPQEPEEDE

  • Predicted Molecular Mass

    87.4 kDa

  • Molecular Weight

    Approximately 90-110 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Calculators

Reconstitution Calculator

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Dilution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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