DPP10 - dipeptidyl peptidase like 10 Gene

Also Known as DPL2; DPPY; DPRP3; DPRP-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57628

About DPP10

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:114,442,641-115,845,780 (from NCBI)

This gene has 13 transcripts (splice variants), 272 orthologues and 6 paralogues. Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues.

Summary

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DPP10 Products (18)

mRNA Protein Name
NM_001004360.5 NP_001004360.3 inactive dipeptidyl peptidase 10 isoform short
NM_001178034.1 NP_001171505.1 inactive dipeptidyl peptidase 10 isoform c
NM_001178036.3 NP_001171507.2 inactive dipeptidyl peptidase 10 isoform a
NM_001178037.3 NP_001171508.2 inactive dipeptidyl peptidase 10 isoform b
NM_001321905.3 NP_001308834.2 inactive dipeptidyl peptidase 10 isoform d
NM_001321906.2 NP_001308835.2 inactive dipeptidyl peptidase 10 isoform short
NM_001321907.3 NP_001308836.2 inactive dipeptidyl peptidase 10 isoform e
NM_001321908.3 NP_001308837.2 inactive dipeptidyl peptidase 10 isoform f
NM_001321909.3 NP_001308838.2 inactive dipeptidyl peptidase 10 isoform g
NM_001321910.3 NP_001308839.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321911.3 NP_001308840.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321912.3 NP_001308841.2 inactive dipeptidyl peptidase 10 isoform h
NM_001321913.3 NP_001308842.2 inactive dipeptidyl peptidase 10 isoform i
NM_001321914.2 NP_001308843.2 inactive dipeptidyl peptidase 10 isoform i
NM_001399849.1 NP_001386778.1 inactive dipeptidyl peptidase 10 isoform a
NM_001399850.1 NP_001386779.1 inactive dipeptidyl peptidase 10 isoform i
NM_001399851.1 NP_001386780.1 inactive dipeptidyl peptidase 10 isoform j
NM_020868.6 NP_065919.3 inactive dipeptidyl peptidase 10 isoform long

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables dipeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
12662155 GOA
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
27198182 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
15671030 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
12662155 GOA
part of voltage-gated potassium channel complex IPI
IPI: Inferred from physical interaction
27198182 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DPP10 Protein Structure

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (133 - 499)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (581 - 783)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
Protein Preferred Names Protein Names

inactive dipeptidyl peptidase 10

  • DPP X

Recombinant DPP10 Proteins

Cat. No. Product Name Accession Purity
HY-P75281 DPP10 Protein, Human (HEK293, His) Q8N608-1 (L56-E796) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Near-Fatal Asthma
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03961 DPP10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18810 Dpp10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25300 Dpp10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus DPP10 VGNC VGNC:61602
Bos taurus DPP10 VGNC VGNC:28186
Mus musculus DPP10 MGD MGI:2442409
Canis familiaris DPP10 VGNC VGNC:40072
Rattus norvegicus DPP10 RGD RGD:1306427
Macaca mulatta DPP10 VGNC VGNC:71873
Others DPP10 NCBI