2. Cell Cycle/DNA Damage Autophagy
  3. Deubiquitinase Mitophagy
  4. Q14

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Q14

Q14 Chemical Structure

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Based on 1 publication(s) in Google Scholar

Q14 Related Antibodies

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View All Deubiquitinase Isoform Specific Products:

View All Isoforms
USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

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Description

Q14 is a polypeptide derived from the USP30 (ubiquitin specific peptidase 30) transmembrane (TM) domain with the ability to inhibit the deubiquitination activity of USP30 (IC50=57.2 nM). Q14 reduces USP30 activity by inhibiting the interaction between the USP30 transmembrane domain and its catalytic domain. Q14 peptide contains the LC3 interaction region (LIR) motif, which enables it to bind to the LC3 and accelerate the formation of autophagosomes, thereby promoting mitophagy. Q14 can be used in the study of neurodegenerative diseases as well as mitochondrial quality control and cell metabolism[1].

IC50 & Target[1]

USP30

57.2 nM (IC50)

Molecular Weight

2198.62

Formula

C101H168N32O23
Appearance

Solid

Color

White to off-white

Sequence

Ac-Gly-Ile-Tyr-Val-Ile-Trp-Gly-Pro-Ile-Thr-Glu-Arg-Lys-Lys-Arg-Arg-Lys-Gly-NH2
Sequence Shortening

Ac-GIYVIWGPITERKKRRKG-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (45.48 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4548 mL 2.2742 mL 4.5483 mL
5 mM 0.0910 mL 0.4548 mL 0.9097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4548 mL 2.2742 mL 4.5483 mL 11.3708 mL
5 mM 0.0910 mL 0.4548 mL 0.9097 mL 2.2742 mL
10 mM 0.0455 mL 0.2274 mL 0.4548 mL 1.1371 mL
15 mM 0.0303 mL 0.1516 mL 0.3032 mL 0.7581 mL
20 mM 0.0227 mL 0.1137 mL 0.2274 mL 0.5685 mL
25 mM 0.0182 mL 0.0910 mL 0.1819 mL 0.4548 mL
30 mM 0.0152 mL 0.0758 mL 0.1516 mL 0.3790 mL
40 mM 0.0114 mL 0.0569 mL 0.1137 mL 0.2843 mL
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Q14 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Q14Q14 peptideQ 14Q-14DeubiquitinaseMitophagyDUBsMitochondrial AutophagyUSP30peptidedeubiquitinationLC3mitochondrial autophagyneurodegenerative diseasesInhibitorinhibitorinhibit

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