LAP3 Protein, Human (HEK293, His)

The LAP3 protein is a cytosolic metallopeptidase that serves as a catalytic entity responsible for the removal of unsubstituted N-terminal hydrophobic amino acids from a variety of peptides. The peptidase activity of LAP3 depends on the presence of Zn(2+) ions, and its substrate specificity can be modulated by binding to other cofactors. LAP3 Protein, Human (HEK293, His) is the recombinant human-derived LAP3 protein, expressed by HEK293 , with C-His labeled tag. The total length of LAP3 Protein, Human (HEK293, His) is 519 a.a., with molecular weight of ~57.6 kDa.

Leucine aminopeptidase 3 (LAP3) is a cytosolic metallopeptidase crucial for catalyzing the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The enzymatic activity of LAP3 is contingent upon the presence of Zn(2+) ions, and the association with other cofactors can modulate its substrate specificity. In the presence of Mn(2+), LAP3 exhibits a specific Cys-Gly hydrolyzing activity, targeting Cys-Gly-S-conjugates. This peptidase is notably involved in the metabolism of glutathione and the degradation of glutathione S-conjugates, suggesting a role in regulating the cellular redox status. The diverse substrate specificity and involvement in cellular processes underscore the significance of LAP3 in peptide metabolism and cellular redox control.

Human

HEK293

C-His

P28838/NP_056991.2 (M1-A519)

51056  [NCBI]

Approximately 57.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.