LAP3 - leucine aminopeptidase 3 Gene

Also Known as LAP; PEPS; LAPEP; HEL-S-106

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51056

About LAP3

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,577,198-17,607,970 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LAP3 Products (1)

mRNA Protein Name
NM_015907.3 NP_056991.2 cytosol aminopeptidase

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAP3 Protein Structure

Peptidase_M17_N

Peptidase_M17_N: Cytosol aminopeptidase family, N-terminal domain (37 - 169)

Peptidase_M17

Peptidase_M17: Cytosol aminopeptidase family, catalytic domain (196 - 509)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 519 a.a.
Protein Preferred Names Protein Names

cytosol aminopeptidase

  • cysteinylglycine-S-conjugate dipeptidase

LAP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LAP3 P28838 PIH1D2 Homo sapiens Q8WWB5
Validated Y2H
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Validated Y2H
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
LAP3 P28838 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Array
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 ZYX Homo sapiens Q15942
Validated Y2H
32296183
Intra
LAP3 P28838 ZNF76 Homo sapiens P36508
Validated Y2H
32296183
Intra
LAP3 P28838 MAPRE3 Homo sapiens Q9UPY8
Validated Y2H
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Array
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Y2H Prey Pooling
32296183
Intra
LAP3 P28838 CBX3 Homo sapiens Q13185
Validated Y2H
32296183
Intra
LAP3 P28838 CBX5 Homo sapiens P45973
Validated Y2H
32296183
Intra
LAP3 P28838 CBX5 Homo sapiens P45973
Y2H Array
32296183
Intra
LAP3 P28838 PIK3R3 Homo sapiens Q92569
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAP3 Proteins

Cat. No. Product Name Accession Purity
HY-P74780 LAP3 Protein, Human (HEK293, His) P28838/NP_056991.2 (M1-A519) ≥ 90%, as determined by reducing SDS-PAGE.

LAP3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86940 LAP3 Antibody (YA6633) WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Bacterial Vaginosis

  • Vaginosis, Bacterial
Haverhill Fever

  • Streptobacillosis

  • Streptobacillary Rat-Bite Fever

  • Streptobacillary Fever

  • Rat-Bite Fever Due To Streptobacillus Moniliformis

  • Erythema Arthriticum Epidemicum

  • Epidemic Arthritic Erythema
Cholestasis

  • Obstruction Of Bile Duct

  • Bile Duct Obstruction

  • Bile Occlusion

  • Extrahepatic Biliary Obstruction

  • Extrahepatic Bile Duct Obstruction

  • Bile Stasis

  • Biliary Stasis

  • Obstructive Hyperbilirubinemia

  • Obstructed Jaundice

  • Bile Duct Obstructed

  • Bile Ductal Obstruction

  • Biliary Duct Obstruction

  • Obstructed Bile Ductal

  • Obstructed Biliary Duct

  • Obstructed Biliary Ductal

  • Jaundice Regurgitation

  • Obstructive Jaundice

  • Cholestatic Jaundice

  • Cholestatic Jaundice Syndrome
Syphilitic Meningitis

  • Syphilitic Aseptic Meningitis

  • Meningeal Syphilis

  • Meningitis, Syphilitic
Vaginitis

  • Infective Vaginitis

  • Inflammation Of Vagina

  • Colpitis

  • Vaginal Inflammation

  • Vaginitis Nos
Vaginal Disease

  • Vaginal Diseases
Vaginal Discharge
Specific Language Impairment

  • Language Impairment, Specific
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-137844 L-Leucine-7-amido-4-methylcoumarin hydrochloride 99.98% Unkown
HY-108546 L-AP3 Antagonist 99.91% Unkown
HY-RS03406 CXCR4 Human Pre-designed siRNA Set A / Unkown
HY-RS07520 LAP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17812 Lap3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24280 Lap3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus LAP3 VGNC VGNC:78519
Mus musculus LAP3 MGD MGI:1914238
Bos taurus LAP3 VGNC VGNC:30786
Macaca mulatta LAP3 VGNC VGNC:97784
Canis familiaris LAP3 VGNC VGNC:42582
Rattus norvegicus LAP3 RGD RGD:1307985
Others LAP3 NCBI