LAP3 - leucine aminopeptidase 3 Gene

Homo sapiens

Also known as LAP; PEPS; LAPEP; HEL-S-106

Gene ID: 51056 | Gene type: protein coding

About LAP3

Cytogenetic location: 4p15.32 Genomic coordinates (GRCh38): 4:17,577,198-17,607,970 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 73.5), lymph node (RPKM 68.4) and 24 other tissues.

Summary

Predicted to enable peptidase activity. Predicted to be involved in proteolysis. Located in cytosol; midbody; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

LAP3 Products(1)

mRNA	Protein	Name
NM_015907.3	NP_056991.2	cytosol aminopeptidase

LAP3 Protein Structure

Peptidase_M17_N

Peptidase_M17

0
100
200
300
400
519 a.a.

Protein Preferred Names

Protein Names

cytosol aminopeptidase

cysteinylglycine-S-conjugate dipeptidase

Recombinant LAP3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74780	LAP3 Protein, Human (HEK293, His)	P28838/NP_056991.2 (M1-A519)	≥95%

Related Diseases

Diseases

Alias

Bacterial Vaginosis

Vaginosis, Bacterial

Haverhill Fever

Streptobacillosis	Streptobacillary Rat-Bite Fever
Streptobacillary Fever	Rat-Bite Fever Due To Streptobacillus Moniliformis
Erythema Arthriticum Epidemicum	Epidemic Arthritic Erythema

Cholestasis

Obstruction Of Bile Duct	Bile Duct Obstruction
Bile Occlusion	Extrahepatic Biliary Obstruction
Extrahepatic Bile Duct Obstruction	Bile Stasis
Biliary Stasis	Obstructive Hyperbilirubinemia
Obstructed Jaundice	Bile Duct Obstructed
Bile Ductal Obstruction	Biliary Duct Obstruction
Obstructed Bile Ductal	Obstructed Biliary Duct
Obstructed Biliary Ductal	Jaundice Regurgitation
Obstructive Jaundice	Cholestatic Jaundice
Cholestatic Jaundice Syndrome

Syphilitic Meningitis

Syphilitic Aseptic Meningitis	Meningeal Syphilis
Meningitis, Syphilitic

Vaginitis

Infective Vaginitis	Inflammation Of Vagina
Colpitis	Vaginal Inflammation
Vaginitis Nos

Vaginal Disease

Vaginal Diseases

Vaginal Discharge

Specific Language Impairment

Language Impairment, Specific

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-137844	L-Leucine-7-amido-4-methylcoumarin hydrochloride		99.17%	Unkown
HY-108546	L-AP3	Antagonist	/	Unkown
HY-RS07520	LAP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LAP3	VGNC	VGNC:78519
Mus musculus	LAP3	MGD	MGI:1914238
Bos taurus	LAP3	VGNC	VGNC:30786
Macaca mulatta	LAP3	VGNC	VGNC:97784
Canis familiaris	LAP3	VGNC	VGNC:42582
Rattus norvegicus	LAP3	RGD	RGD:1307985
Others	LAP3	NCBI

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