1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.

For research use only. We do not sell to patients.

NVP-DPP728 dihydrochloride Chemical Structure

NVP-DPP728 dihydrochloride Chemical Structure

CAS No. : 207556-62-5

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Description

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].

IC50 & Target

Ki: 11 nM (DPP-IV) [1]

In Vitro

NVPDPP728 inhibits human and rat plasma DPP-IV (IC50s: 5-10 nM) with >15 000-fold selectivity relative to DPP-II and a range of proline-cleaving proteases[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

NVP-DPP728 (3.72 mg/kg; p.o.) inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese (fa/fa) and lean (FA/?) Zucker rats[2]
Dosage: 3.72 mg/kg
Administration: Oral administration
Result: Led to inhibition of plasma DPP-IV activity.
Molecular Weight

371.26

Formula

C15H20Cl2N6O

CAS No.
SMILES

N#CC1=CC=C(NCCNCC(N2[C@H](C#N)CCC2)=O)N=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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NVP-DPP728 dihydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
NVP-DPP728 dihydrochloride
Cat. No.:
HY-14293
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