1. Metabolic Enzyme/Protease
  2. Dipeptidyl Peptidase
  3. NVP-DPP728 dihydrochloride

NVP-DPP728 dihydrochloride 

Cat. No.: HY-14293
Handling Instructions

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus.

For research use only. We do not sell to patients.

NVP-DPP728 dihydrochloride Chemical Structure

NVP-DPP728 dihydrochloride Chemical Structure

CAS No. : 207556-62-5

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Description

NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].

IC50 & Target

Ki: 11 nM (DPP-IV) [1]

In Vivo

NVP-DPP728 inhibits DPP-IV and improves insulin secretion and glucose tolerance, probably through augmentation of the effects of endogenous GLP-1[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Obese (fa/fa) and lean (FA/?) Zucker rats[2]
Dosage: 3.715 mg/kg
Administration: Oral administration
Result: Led to inhibition of plasma DPP-IV activity.
Molecular Weight

371.26

Formula

C₁₅H₂₀Cl₂N₆O

CAS No.

207556-62-5

SMILES

N#CC1=CC=C(NCCNCC(N2[[email protected]](C#N)CCC2)=O)N=C1.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NVP-DPP728Dipeptidyl PeptidaseDPPdipeptidylpeptidaseIVDPP-IVdiabetesmellitusInhibitorinhibitorinhibit

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Product Name:
NVP-DPP728 dihydrochloride
Cat. No.:
HY-14293
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