207556-62-5
207556-62-5
Chemical Structure
NVP-DPP728 dihydrochloride
- CAS No.: 207556-62-5
- Formula:C15H20Cl2N6O
- Molecular Weight:371.26
IUPAC Name: (S)-6-((2-((2-(2-cyanopyrrolidin-1-yl)-2-oxoethyl)amino)ethyl)amino)nicotinonitrile dihydrochloride
InChIKey: VNACOBVZDCLAEV-GXKRWWSZSA-N
SMILES: N#CC1=CC=C(NCCNCC(N2[C@H](C#N)CCC2)=O)N=C1.[H]Cl.[H]Cl
Biological Activity: NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus[1][2].
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NVP-DPP728 dihydrochloride | NVP-DPP728 dihydrochloride is a potent, selective and orally active dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 11 nM. NVP-DPP728 dihydrochloride can be used for the research of diabetes mellitus. | |||||||||||||||||||||
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References
- [1]. T E Hughes, et al. NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV. Biochemistry. 1999 Sep 7;38(36):11597-603. [Content Brief]
- [2]. B Balkan, et al. Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats. Diabetologia. 1999 Nov;42(11):1324-31. [Content Brief]
Keywords
