1. Recombinant Proteins
  2. Enzymes & Regulators
  3. Protease Inhibitors
  4. Serpin (Protease Inhibitor)
  5. Protease Nexin I
  6. Serpin E2 Protein, Human (HEK293, His)

Serpin E2 Protein, Human (HEK293, His)

Cat. No.: HY-P71085
Handling Instructions

Serpin E2 is a serine protease inhibitor that inhibits thrombin, trypsin, and urokinase. Its unique role in promoting neurite extension involves specific inhibition of thrombin activity. Serpin E2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E2 Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~50.0 kDa.

For research use only. We do not sell to patients.

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Description

Serpin E2 is a serine protease inhibitor that inhibits thrombin, trypsin, and urokinase. Its unique role in promoting neurite extension involves specific inhibition of thrombin activity. Serpin E2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin E2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin E2 Protein, Human (HEK293, His) is 378 a.a., with molecular weight of ~50.0 kDa.

Background

Serpin E2, a serine protease inhibitor, exhibits inhibitory activity towards thrombin, trypsin, and urokinase. Notably, it plays a role in promoting neurite extension by specifically inhibiting thrombin activity. Through its interactions with thrombin, serpin E2 contributes to the regulation of proteolytic processes involved in various cellular functions. Additionally, the protein demonstrates binding affinity for heparin, suggesting its involvement in interactions with glycosaminoglycans and potentially modulating its activity in the context of cellular signaling or other biological processes.

Species

Human

Source

HEK293

Tag

C-6*His

Accession

P07093-2 (S20-P397)

Gene ID
Synonyms
Glia-derived Nexin; GDN; Peptidase inhibitor 7; PI-7; Protease nexin 1; PN-1; Protease nexin I; Serpin E2; SERPINE2; PI7; PN1
AA Sequence

SHFNPLSLEELGSNTGIQVFNQIVKSRPHDNIVISPHGIASVLGMLQLGADGRTKKQLAMVMRYGVNGVGKILKKINKAIVSKKNKDIVTVANAVFVKNASEIEVPFVTRNKDVFQCEVRNVNFEDPASACDSINAWVKNETRDMIDNLLSPDLIDGVLTRLVLVNAVYFKGLWKSRFQPENTKKRTFVAADGKSYQVPMLAQLSVFRCGSTSAPNDLWYNFIELPYHGESISMLIALPTESSTPLSAIIPHISTKTIDSWMSIMVPKRVQVILPKFTAVAQTDLKEPLKVLGITDMFDSSKANFAKITRSENLHVSHILQKAKIEVSEDGTKASAATTAILIARSSPPWFIVDRPFLFFIRHNPTGAVLFMGQINKP

Molecular Weight

Approximately 50.0 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

Serpin E2 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Serpin E2 Protein, Human (HEK293, His)
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HY-P71085
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