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Cat. No.: HY-N12043

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Bidenoside C

Name: Bidenoside C
Brand: MedChemExpress
SKU: HY-N12043
Price: 189.00 USD
Availability: InStock
Rating: 5 (1 reviews)

Bidenoside C is a polyacetylene glycoside found in Coreopsis lanceolata (Asteraceae). Bidenoside C increases AMPK phosphorylation and inhibits adipogenesis and lipid accumulation in preadipocytes. Bidenoside C downregulates the expression of the adipogenic gene SREBP1 and upregulates the expression of the lipolytic gene ATGL. Bidenoside C weakly inhibits LPS (HY-D1056)-induced nitric oxide production in mouse macrophages. Bidenoside C can be used in obesity-related research.

For research use only. We do not sell to patients.

CAS No.: 700877-55-0
Formula: C₁₆H₂₂O₆
Molecular Weight:310.34

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (279 KB)

Bidenoside C Chemical Structure

CAS No.: 700877-55-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

All AMPK Isoforms :

In Vitro

Innate ImmunityLipid MetabolismOthers

Innate Immunity

Bidenoside C (10 μM) has a weak inhibitory effect on LPS (HY-D1056)-induced NO production in mouse macrophages^[2].

Lipid Metabolism

Bidenoside C (20 µM; until day 8) inhibits adipogenesis and lipid accumulation in 3T3-L1 preadipocytes^[1].
Bidenoside C (20 µM; throughout the entire adipocyte differentiation process) inhibits Adipsin, Fabp4, and SREBP1 and increases ATGL mRNA in 3T3-L1 adipocytes^[1].
Bidenoside C (20 µM; throughout the entire adipocyte differentiation process) activates AMPK in 3T3-L1 adipocytes^[1].

Others

Bidenoside C (10-40 µM; 24 h) does not reduce 3T3-L1 preadipocyte viability^[1].
Bidenoside C (0.1-100 µM) does not inhibit human recombinant DPP-IV in the DPP-IV inhibitor screening assay^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

3T3-L1 preadipocytes
Concentration:

10, 20, 40 µM
Incubation Time:

24 h
Result:

Did not exhibit cytotoxicity at 10 and 20 µM.
Did not decrease 3T3-L1 preadipocyte viability at 40 µM after 24 h.

Cell Differentiation Assay^[2]

Cell Line:

differentiated 3T3-L1 adipocytes
Concentration:

20 µM
Incubation Time:

Throughout adipogenic differentiation until Day 8
Result:

Prevented de novo generation of adipocytes and lipid accumulation within adipocytes at 20 µM.

Real Time qPCR^[2]

Cell Line:

differentiated 3T3-L1 adipocytes
Concentration:

20 µM
Incubation Time:

Throughout adipogenic differentiation
Result:

Reduced transcription levels of Adipsin and Fabp4.
Suppressed SREBP1 expression.
Increased ATGL mRNA expression.
Did not enhance HSL mRNA expression.

Western Blot Analysis^[2]

Cell Line:

differentiated 3T3-L1 adipocytes
Concentration:

20 µM
Incubation Time:

Throughout adipogenic differentiation
Result:

Increased phosphorylation of AMPK compared with total AMPK.

Related Protocols :

Chemical Information

CAS No. 700877-55-0
Molecular Weight 310.34
Formula C₁₆H₂₂O₆
SMILES

C/C=C\C#CC#CCCCO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO
Structure Classification
- Saccharides
- Monosaccharides
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Baek SC, et al. Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius). Biomedicines 2021, 9, 91 [Internet]. 2021

[2]. He J, et al. New polyacetylene glucosides from the florets of Carthamus tinctorius and their weak anti-inflammatory activities. Carbohydrate research. 2011 Sep 27;346(13):1903-8.

[3]. Kim BR, et al. Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects. Molecules. 2020 Sep 23;25(19):4370. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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