USP39 Antibody (YA6827)

USP39 Antibody (YA6827) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.

Predicted band size: 65 kDa

Q53GS9

10713 [NCBI]

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Function：Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q53GS9 has three isomers: Q53GS9-1: 65381 Da (predicted); Q53GS9-2: 53510 Da (predicted); Q53GS9-3: 56359 Da (predicted).

Subunit：The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:11350945, PubMed:26912367)

65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody;