USP39 Antibody (YA6827)
(Synonyms: 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody; )USP39 Antibody (YA6827) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human, Mouse
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Formulation:
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:200 |
Product Details
USP39 Antibody (YA6827) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse Predicted Reactivity: Rat
Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
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Calculated Molecular Weight Predicted band size: 65 kDa
Recombinant protein within human USP39 aa 466-565/565.
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
USP39 is a Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination. Contributes to non-canonical Wnt signaling during epidermal differentiation. Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA[1][2][3][4][5][6][7].
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Subcellular Localization
Nucleus
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Isoforms & Post-Translational Modification
Q53GS9 has three isomers: Q53GS9-1: 65381 Da (predicted); Q53GS9-2: 53510 Da (predicted); Q53GS9-3: 56359 Da (predicted).
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Subunit
The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:11350945, PubMed:26912367)
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SwissProt ID
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Synonyms
65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody;
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