USP30 inhibitor 11
Based on 1 Customer Validation
USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 μΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.
For research use only. We do not sell to patients.
- Purity: 99.81%
- CAS No.: 2067332-64-1
- Formula: C17H16N6O2S
- Molecular Weight:368.41
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.01 µΜ (USP30)[1]
USP30 is a 517 amino acid protein which is found in the mitochondrial outer membrane. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins[1].USP30 inhibitor 11 (0.01-30 μΜ; λEx=540 nm; λEm=590 nm) inhibits USP30 biochemical activity with an IC50 of 0.01 μΜ in a USP30 biochemical IC50 assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2067332-64-1
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Appearance Solid
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Molecular Weight 368.41
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Formula C17H16N6O2S
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Color White to off-white
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SMILES
O=C([C@H]1N(C#N)CCC1)N(C2=NC(C3=NC(C#N)=C(OC)C=C3)=CS2)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 33.33 mg/mL (90.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 2.7144 mL | 13.5718 mL | 27.1437 mL | 67.8592 mL |
| 5 mM | 0.5429 mL | 2.7144 mL | 5.4287 mL | 13.5718 mL | |
| 10 mM | 0.2714 mL | 1.3572 mL | 2.7144 mL | 6.7859 mL | |
| 15 mM | 0.1810 mL | 0.9048 mL | 1.8096 mL | 4.5239 mL | |
| 20 mM | 0.1357 mL | 0.6786 mL | 1.3572 mL | 3.3930 mL | |
| 25 mM | 0.1086 mL | 0.5429 mL | 1.0857 mL | 2.7144 mL | |
| 30 mM | 0.0905 mL | 0.4524 mL | 0.9048 mL | 2.2620 mL | |
| 40 mM | 0.0679 mL | 0.3393 mL | 0.6786 mL | 1.6965 mL | |
| 50 mM | 0.0543 mL | 0.2714 mL | 0.5429 mL | 1.3572 mL | |
| 60 mM | 0.0452 mL | 0.2262 mL | 0.4524 mL | 1.1310 mL | |
| 80 mM | 0.0339 mL | 0.1696 mL | 0.3393 mL | 0.8482 mL |
USP30 inhibitor 11 Related Classifications
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