1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. USP30 inhibitor 11

USP30 inhibitor 11 

Cat. No.: HY-111623
Handling Instructions

USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.

For research use only. We do not sell to patients.

USP30 inhibitor 11 Chemical Structure

USP30 inhibitor 11 Chemical Structure

CAS No. : 2067332-64-1

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Description

USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction[1].

IC50 & Target

IC50: 0.01 µΜ (USP30)[1]

In Vitro

USP30 is a 517 amino acid protein which is found in the mitochondrial outer membrane. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins[1].
USP30 inhibitor 11 (0.01-30 µΜ; λEx=540 nm; λEm=590 nm) inhibits USP30 biochemical activity with an IC50 of 0.01 µΜ in a USP30 biochemical IC50 assay[1].

Molecular Weight

368.41

Formula

C₁₇H₁₆N₆O₂S

CAS No.

2067332-64-1

SMILES

O=C([[email protected]]1N(C#N)CCC1)N(C2=NC(C3=NC(C#N)=C(OC)C=C3)=CS2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

USP30 inhibitor 11DeubiquitinaseDUBsMultiplemyelomacancerusp30DUBdeubiquitylateenzymemitochondrialdysfunctionInhibitorinhibitorinhibit

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USP30 inhibitor 11
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