1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. USP30 inhibitor 11

USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.

For research use only. We do not sell to patients.

USP30 inhibitor 11 Chemical Structure

USP30 inhibitor 11 Chemical Structure

CAS No. : 2067332-64-1

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10 mg USD 980 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 µΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction[1].

IC50 & Target

IC50: 0.01 µΜ (USP30)[1]

In Vitro

USP30 is a 517 amino acid protein which is found in the mitochondrial outer membrane. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins[1].
USP30 inhibitor 11 (0.01-30 µΜ; λEx=540 nm; λEm=590 nm) inhibits USP30 biochemical activity with an IC50 of 0.01 µΜ in a USP30 biochemical IC50 assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

368.41

Formula

C17H16N6O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1N(C#N)CCC1)N(C2=NC(C3=NC(C#N)=C(OC)C=C3)=CS2)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (90.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7144 mL 13.5718 mL 27.1437 mL
5 mM 0.5429 mL 2.7144 mL 5.4287 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.81%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7144 mL 13.5718 mL 27.1437 mL 67.8592 mL
5 mM 0.5429 mL 2.7144 mL 5.4287 mL 13.5718 mL
10 mM 0.2714 mL 1.3572 mL 2.7144 mL 6.7859 mL
15 mM 0.1810 mL 0.9048 mL 1.8096 mL 4.5239 mL
20 mM 0.1357 mL 0.6786 mL 1.3572 mL 3.3930 mL
25 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7144 mL
30 mM 0.0905 mL 0.4524 mL 0.9048 mL 2.2620 mL
40 mM 0.0679 mL 0.3393 mL 0.6786 mL 1.6965 mL
50 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
60 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1310 mL
80 mM 0.0339 mL 0.1696 mL 0.3393 mL 0.8482 mL
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USP30 inhibitor 11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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USP30 inhibitor 11
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HY-111623
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