DPP IV/hCA II-IN-1
DPP IV/hCA II-IN-1 is a potent and selective dipeptidyl peptidase IV (DPP IV) and carbonic anhydrase (CA) inhibitor with an IC50 value of 0.049 μM for DPP IV and with Ki values of 0.0361, 0.0428, 0.0941, 0.1328, 0.2615, and 3.034 μM for CA II, CA VB, CA VA, CA IX, CA I, and CA IV, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2836996-95-1
- Formula: C17H20N2O5S
- Molecular Weight:364.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CA Ⅱ 36.1 nM (IC50) |
CA I 0.2615 μM (Ki) |
hCA II 0.0361 μM (Ki) |
hCA IX 0.1328 (Ki) |
DPP IV/hCA II-IN-1 (compound 12; 100 nM and 5 μM; 1 h; Caco-2 cells) inhibits cellular DPP IV activity by 60.65% and 71.86% at 100.0 nM and 5.0 μM, respectively[1].
DPP IV/hCA II-IN-1 (1.0 μM) can be uptaken by Caco-2 cells to 2874, 4562, and 6250 RFU after 15, 30, and 60 min, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2836996-95-1
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Molecular Weight 364.42
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Formula C17H20N2O5S
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SMILES
NC(C1COC2=CC=CC=C2O1)CCOC3=CC=C(C=C3)S(=O)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DPP IV/hCA II-IN-1 Related Classifications
HY-151578 Related Classifications
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