USP39 Antibody (YA6826)

Cat. No.: HY-P87133: Ficha de datos COA
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USP39 Antibody (YA6826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.

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Tamaño	Stock	Cantidad
20 μL	En stock	Estimated Time of Arrival: December 31
50 μL	En stock	Estimated Time of Arrival: December 31
100 μL	En stock	Estimated Time of Arrival: December 31
250 μL	Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Verification Image
Background
Descripciòn

Descripciòn

USP39 Antibody (YA6826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Peso molecular

Predicted band size: 65 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q53GS9

Gene ID

10713 [NCBI]

Immunogen

Recombinant protein within human USP39 aa 151-350/565.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:200

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from HeLa (lane 1(20μg)) 、HEK293 (lane 2(20μg)) 、C2C12 (lane 3(20μg)) and Rat testis (lane 4(20μg)) using USP39 Antibody (HY-P87133) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

Background

Function：Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development (PubMed:33127822, PubMed:34614178). Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome (PubMed:11350945, PubMed:26912367). Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development (By similarity). Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint (PubMed:18728397). Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2 (PubMed:30771428). Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair (PubMed:34614178). Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination (PubMed:33127822). Contributes to non-canonical Wnt signaling during epidermal differentiation (By similarity). Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA (PubMed:36651806)

Subcellular Localization：Nucleus

Isoforms & Post-Translational Modification：Q53GS9 has three isomers: Q53GS9-1: 65381 Da (predicted); Q53GS9-2: 53510 Da (predicted); Q53GS9-3: 56359 Da (predicted).

Subunit：The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:11350945, PubMed:26912367)

Synonyms

65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody;

Documentación

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Ficha de datos (231 KB) SDS (254 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)