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USP39 Antibody (YA6826)

(Synonyms: 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody; )
Customer Review

Based on 1 Customer Validation

USP39 Antibody (YA6826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for USP39 Antibody (YA6826)
  • USP39 Antibody (YA6826) Product Image
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Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Data Download
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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
Dilution Ratio 1:500-1:2000 1:50-1:200

Product Details

Description

USP39 Antibody (YA6826) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to USP39.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Calculated Molecular Weight Predicted band size: 65 kDa
Immunogen

Recombinant protein within human USP39 aa 151-350/565.

Purification

affinity purified.

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for USP39 Antibody (YA6826)
    Western blot analysis of extracts from HeLa (lane 1(20μg)) 、HEK293 (lane 2(20μg)) 、C2C12 (lane 3(20μg)) and Rat testis (lane 4(20μg)) using USP39 Antibody (HY-P87133) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

Background

  • Function

    USP39 is a Deubiquitinating enzyme that plays a role in many cellular processes including cellular antiviral response, epithelial morphogenesis, DNA repair or B-cell development. Plays a role in pre-mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the precatalytic spliceosome. Specifically regulates immunoglobulin gene rearrangement in a spliceosome-dependent manner, which involves modulating chromatin interactions at the Igh locus and therefore plays an essential role in B-cell development. Regulates AURKB mRNA levels, and thereby plays a role in cytokinesis and in the spindle checkpoint. Regulates apoptosis and G2/M cell cycle checkpoint in response to DNA damage by deubiquitinating and stabilizing CHK2. Also plays an important role in DNA repair by controlling the recruitment of XRCC4/LIG4 to DNA double-strand breaks for non-homologous end-joining repair. Participates in antiviral activity by affecting the type I IFN signaling by stabilizing STAT1 and decreasing its 'Lys-6'-linked ubiquitination. Contributes to non-canonical Wnt signaling during epidermal differentiation. Acts as a negative regulator NF-kappa-B activation through deubiquitination of 'Lys-48'-linked ubiquitination of NFKBIA[1][2][3][4][5][6][7].

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    Q53GS9 has three isomers: Q53GS9-1: 65381 Da (predicted); Q53GS9-2: 53510 Da (predicted); Q53GS9-3: 56359 Da (predicted).

  • Subunit

    The U4/U6-U5 tri-snRNP complex is a building block of the precatalytic spliceosome (spliceosome B complex) (PubMed:11350945, PubMed:26912367)

  • SwissProt ID

    Q53GS9

  • Gene ID
    10713 [NCBI]
  • Synonyms

    65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; 65K antibody; CGI 21 antibody; CGI-21 antibody; FLJ33136 antibody; HSPC332 antibody; Inactive ubiquitin specific peptidase 39 antibody; Inactive ubiquitin-specific peptidase 39 antibody; MGC75069 antibody; PRO2855 antibody; S. CEREVISIAE, HOMOLOG OF SAD1 antibody; SAD1 antibody; SAD1 homolog antibody; Small nuclear ribonucleoprotein 65kDa (U4/U6.U5) antibody; snRNP ASSEMBLY DEFECTIVE 1 antibody; SnRNP assembly defective 1 homolog antibody; SNRNP65 antibody; SNUT2_HUMAN antibody; U4/U6.U5 tri snRNP associated 65 kDa protein antibody; U4/U6.U5 tri snRNP associated protein 2 antibody; U4/U6.U5 tri-snRNP-associated 65 kDa protein antibody; U4/U6.U5 tri-snRNP-associated protein 2 antibody; Ubiquitin specific peptidase 39 antibody; Ubiquitin specific protease 39 antibody; USP39 antibody;

USP39 Antibody (YA6826) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from HeLa (lane 1(20μg)) 、HEK293 (lane 2(20μg)) 、C2C12 (lane 3(20μg)) and Rat testis (lane 4(20μg)) using USP39 Antibody (HY-P87133) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • USP39 Antibody (YA6826) Product Image
    1/16
  • Experimental Validation Results for USP39 Antibody (YA6826)
  • USP39 Antibody (YA6826) Product Image
  • Experimental Validation Results for USP39 Antibody (YA6826)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from HeLa (lane 1(20μg)) 、HEK293 (lane 2(20μg)) 、C2C12 (lane 3(20μg)) and Rat testis (lane 4(20μg)) using USP39 Antibody (HY-P87133) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.
  • Experimental Validation Results for USP39 Antibody (YA6826)
  • USP39 Antibody (YA6826) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from HeLa (lane 1(20μg)) 、HEK293 (lane 2(20μg)) 、C2C12 (lane 3(20μg)) and Rat testis (lane 4(20μg)) using USP39 Antibody (HY-P87133) . Proteins were transferred to a PVDF membrane and blocked with 5% nonfat dry milk in TBST for 1.5 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Hsp90, 1/10000) was used in 5% nonfat dry milk in TBST at 4℃ overnight. Goat Anti-Rabbit IgG-HRP Secondary Antibody (1/10,000) was used for 1 hour at room temperature.

  • USP39 Antibody (YA6826) Product Image WB