TPP1 Protein, Mouse (sf9, His)

TPP1, a lysosomal serine protease, acts as a non-specific lysosomal peptidase, displaying tripeptidyl-peptidase I activity in lysosomal protein degradation. Its function involves generating tripeptides from the breakdown products of other lysosomal proteinases, emphasizing its role in processing and hydrolyzing peptides within the lysosomal environment. Notably, TPP1 requires substrates with an unsubstituted N-terminus. TPP1 Protein, Mouse (sf9, His) is the recombinant mouse-derived TPP1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of TPP1 Protein, Mouse (sf9, His) is 562 a.a., with molecular weight of ~60.9 kDa.

TPP1, a lysosomal serine protease, exhibits tripeptidyl-peptidase I activity, as evidenced by its involvement in lysosomal protein degradation. While its precise substrate specificity is not yet fully elucidated, TPP1 is thought to function as a non-specific lysosomal peptidase, generating tripeptides from the breakdown products produced by other lysosomal proteinases. Notably, TPP1 requires substrates with an unsubstituted N-terminus, further highlighting its role in processing and hydrolyzing peptides within the lysosomal environment.

Mouse

Sf9 insect cells

C-His

O89023 (M1-P562)

12751  [NCBI]

Approximately 60.9 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.