Tpp1 - tripeptidyl peptidase I Gene

Also Known as Cln2; LPIC; TPP-1; TPP-I

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12751

Summary

This gene encodes a lysosomal serine protease that cleaves N-terminal tripeptides from protein substrates. The encoded preproprotein undergoes autocatalytic processing to generate a mature enzyme. Mice lacking the encoded protein exhibit a progressive neurodegeneration and a greatly shortened lifespan. At the cellular level, mice lacking the encoded protein exhibit accumulation of autofluorescent lipopigments. Mutations in the human ortholog of this gene cause classical late-infantile neuronal ceroid lipofuscinosis. [provided by RefSeq, Nov 2015]

Tpp1 Products (1)

mRNA Protein Name
NM_009906.6 NP_034036.1 tripeptidyl-peptidase 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17053789 MGI
enables tripeptidyl-peptidase activity IDA
IDA: Inferred from direct assay
28728022 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within lysosomal protein catabolic process IMP
IMP: Inferred from mutant phenotype
28728022 MGI
acts upstream of or within lysosome organization IMP
IMP: Inferred from mutant phenotype
15483130 MGI
acts upstream of or within neuromuscular process controlling balance IMP
IMP: Inferred from mutant phenotype
15483130 MGI
Cellular Component GO Annotation Evidence References Source
located in lysosome IDA
IDA: Inferred from direct assay
19941651 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tripeptidyl-peptidase 1

  • ceroid-lipofuscinosis, neuronal 2

  • lysosomal pepstatin-insensitive protease

  • tripeptidyl aminopeptidase

Recombinant Tpp1 Proteins

Cat. No. Product Name Accession Purity
HY-P76112 TPP1 Protein, Mouse (sf9, His) O89023 (T20-P562) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W111141 BCN-OH 99.15% Unkown
HY-P3139 TPP-1 Inhibitor 96.95% Unkown
HY-151404 Antitumor agent-76 Inducer / Unkown
HY-P3139A TPP-1 TFA Inhibitor / Unkown
HY-RS00148 ACD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14942 TPP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17753 Tpp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24220 Tpp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpp1 NCBI NCBI:1200