1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. TPP-1

TPP-1 

Cat. No.: HY-P3139
Handling Instructions

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

TPP-1 Chemical Structure

TPP-1 Chemical Structure

CAS No. : 2426685-25-6

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Description

TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function[1].

In Vitro

TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction. The KD value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1[1].
TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5 to 6-week-old female Balb/c nude mice  injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector[1]
Dosage: 4 mg/kg
Administration: Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result: Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function. 
Molecular Weight

2488.67

Formula

C₁₀₇H₁₅₀N₃₄O₃₂S₂

CAS No.

2426685-25-6

Sequence Shortening

SGQYASYHCWCWRDPGRSGGSK

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TPP-1TPP1TPP 1PD-1/PD-L1PD-1/Programmed death-ligand 1H460tumorcancerInteractionInhibitorinhibitorinhibit

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