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antifungal+agents

" in MedChemExpress (MCE) Product Catalog:

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447

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Fluorescent Dyes

Biochemical Assay Reagents

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GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-148797

Rolusafine	Fungal	Infection
Rolusafine is an antifungal agent.

HY-W1127089

Antifungal agent 136	Fungal Cytochrome P450 Interleukin Related	Infection Inflammation/Immunology
Antifungal agent 136 is a CYP51 inhibitor and antifungal agent. Antifungal agent 136 downregulates the expression of interleukin-6 to alleviate inflammatory responses. Antifungal agent 136 exhibits activity against both drug-sensitive and drug-resistant Candida albicans strains. Antifungal agent 136 can be used in the research of fungal infections and inflammatory diseases .

HY-143335

Antifungal agent 52	Fungal	Infection
Antifungal agent 52 (compound 6c) is a tetrazole derivative. Antifungal agent 52 inhibits the synthesis of Ergosterol (HY-N0181). Antifungal agent 52 exhibit a significant antifungal activity against Candida albicans. Antifungal agent 52 affects C. albicans sessile cell membrane permeabilization .

HY-151566

Antifungal agent 46	Ras Farnesyl Transferase Fungal	Infection
Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase .

HY-139903

Antifungal agent 18	Fungal Calcineurin p38 MAPK	Infection
Antifungal agent 18 is an *antifunga*l agent. Antifungal agent 18 shows a broad-spectrum antifungal activity against major human fungal pathogens. Antifungal agent 18 compromises fungal cell wall integrity by targeting the unfolded protein response (UPR), calcineurin, and MAPK pathways. Antifungal agent 18 shows antifungal activity in virto and vivo. Antifungal agent 18 can be used for the research of invasive fungal pathogens and cutaneous dermatophytes .

HY-146079

Antifungal agent 31	Fungal	Infection
Antifungal agent 31 (compound 12) is a potent and orally active triazole antifungal agents with a pyrrolotriazinone scaffold. Antifungal agent 31 shows antifungal activity against Candida spp. and filamentous fungi. Antifungal agent 31 significantly reduced mortality rates and kidney fungal burden in two murine models of lethal systemic infections .

HY-186027

Antifungal agent 152	Fungal	Infection
Antifungal agent 152 (Compound 27) is an *antifungal* agent. Antifungal agent 152 shows antifungal activity against C. neoformans, C. albicans, C. glabrata with MICs of 4 μg/mL, 16 μg/mL, 16 μg/mL, respectively .

HY-148054

Antifungal agent 36	Fungal	Infection
Antifungal agent 36 is a potent *anti-fungal* agent. Antifungal agent 36 shows anti-fungal activity for Basidiomycetes .

HY-W007980

Antifungal agent 98	Fungal	Infection
Antifungal agent 98 (compound 2) is an antifungal agent. Antifungal agent 98 (100 μg/mL) shows insecticidal activity against Bipolaris sorokinianum, Fusarium oxysporium f. sp.vasinfectum, Pyricularia oryzae, Alternaria Brassicae and Alternaria alternata with a death rate of 41.5%, 40.0%, 23.4, 36.8%, and 35.0% .

HY-156252

Antifungal agent 75	Fungal	Infection
Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .

HY-161312

Antifungal agent 93	Bacterial Fungal	Infection
Antifungal agent 93 (compound 10) is a potent antifungal agent. Antifungal agent 93 shows antimicrobial activity .

HY-102025

Antifungal agent 1	Fungal	Infection
Antifungal agent 1 is a potent *antifungal* agent.

HY-151440

Antifungal agent 42	Fungal	Infection
Antifungal agent 42 is an antifungal agent. Antifungal agent 42 has an inhibitory effect on lanosterol 14α-demethylase (CYP51) of C.alb.. Antifungal agent 42 inhibits biofilm formation .

HY-163781

Antifungal agent 105	Fungal	Infection
Antifungal agent 105 (compound A25) is a potent antifungal agent. Antifungal agent 105 shows protective and curative effects .

HY-151439

Antifungal agent 41	Fungal	Infection
Antifungal agent 41 (compound B01) is an *antifungal agent. Antifungal agent* 41 shows inhibitory effect on Candida albicans in virto and vivo. Antifungal agent 41 can be used for the research of invasive fungal infections .

HY-151442

Antifungal agent 43	Fungal	Infection
Antifungal agent 43 (compound B05) is an antifungal agent. Antifungal agents 43 has antifungal activity by inhibiting biofilm formation. Antifungal agent 43 has low toxicity in human cancer cell lines .

HY-146116

Antifungal agent 32	Fungal	Infection
Antifungal agent 32 (compound 1a) is a potent antifungal agent. Antifungal agent 32 inhibits Candida albicans filamentation and biofilm formation. Antifungal agent 32 inhibits the morphological switching of Candida albicans and its adherence to epithelial cells. Antifungal agent 32 can be used for Candida albicans infections research .

HY-146024

Antifungal agent 28	Fungal	Infection
Antifungal agent 28 (compound 18) is a potent and selective antifungal agent. Antifungal agent 28 inhibits pathogenic strains of C. albicans and non-albicans species including fluconazole-resistant strains. Antifungal agent 28 inhibits Cryptococcus and Aspergillus strains. Antifungal agent 28 disrupts mature Candida biofilm .

HY-147970

Antifungal agent 34	Fungal	Infection
Antifungal agent 34 (compound 6i) is a potent *antifungal* agent. Antifungal agent 34 shows a potent antifungal activity against Candida albicans, with a MIC of 4 µg/mL. Antifungal agent 34 shows significant inhibition on Candida albicans hyphae and biofilm development. Antifungal agent 34 exhibits no cytotoxicity to mammalian cells .

HY-143406

Antifungal agent 25	Fungal	Infection
Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo .

HY-153410

Antifungal agent 49	Fungal	Infection
Antifungal agent 49 (Example 112) is an antifungal agent. Antifungal agent 49 is active against Cryptococcus neoformans with a MIC value of 49 μM .

HY-153409

Antifungal agent 48	Fungal	Infection
Antifungal agent 48 (Example 308) is an antifungal agent. Antifungal agent 48 is active against Cryptococcus neoformans with a MIC value of 11 μM .

HY-176417

Antifungal agent 132	Fungal	Infection
Antifungal agent 132 (compound 25) is a selective and potent antifungal agent. Antifungal agent 132 inhibits Cryptococcus neoformans May1 with a K_i of 180 pM .

HY-147238

Antifungal agent 35	Fungal	Infection
Antifungal agent 35 (compound 24) is a potent antifungal agent. Antifungal agent 35 is a potent enhancer of antifungal activity of Fluconazole against C. albicans .

HY-158980

Antifungal agent 103	Fungal Bacterial	Infection
Antifungal agent 103 (compound 7y) is a potent *antifungal* agent. Antifungal agent 103 inhibits R. solani with an EC₅₀ of 0.47 μg/mL .

HY-153624

Antifungal agent 59	Fungal	Infection
Antifungal agent 59 is an antifungal agent, with MIC values of 0.01-1 μg/mL. Antifungal agent 59 prevents the formation of fungi biofilms, but also has safety .

HY-142914

Antifungal agent 21	Fungal	Others
Antifungal agent 21 is a promising candidate in the development of new agrochemical antifungal agents.

HY-155279

Antifungal agent 73	Fungal	Infection
Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains .

HY-151437

Antifungal agent 40	Fungal	Infection
Antifungal agent 40 is an antifungal agent which extends into the narrow hydrophobic pocket II of C.alb. CYP51. Antifungal agent 40 has an inhibitory effect on lanosterol 14α-demethylase (CYP51). Antifungal agent 40 inhibits biofilm formation .

HY-178340

Antifungal agent 137	Cytochrome P450 Fungal Reactive Oxygen Species (ROS)	Infection
Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC₅₀ of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC₅₀ of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection .

HY-172222

Antifungal agent 127	Fungal	Infection
Antifungal agent 127 (Compound 6c) is an antifungal agent. Antifungal agent 127 exhibits strong inhibitory activity against Botrytis cinerea, Rhizoctonia solani, and other fungi .

HY-151423

Antifungal agent 39	Fungal	Infection
Antifungal agent 39 (Compound 9h) is a broad-spectrum *antifungal* agent .

HY-157018

Antifungal agent 82	Fungal	Infection
Antifungal agent 82 (compound G34) is a *antifungal* agent. Antifungal agent 82 exhibits excellent in vitro antifungal activity against Valsa mali, with an EC₅₀ of 0.57 μg/mL. Antifungal agent 82 also exhibits excellent in vivo protective effects against V. mali at 40 μg/mL .

HY-149821

Antifungal agent 50	Fungal	Infection Inflammation/Immunology
Antifungal agent 50 is an *antifungal* agent, displaying MICs <0.063-1 μg/mL .

HY-168210

Antifungal agent 122	Fungal Cytochrome P450	Infection
Antifungal agent 122 (compound 201) is a potent and broad-spectrum antifungal agent. Antifungal agent 122 prevents fungal phase transition and the formation of fungal biofilm. Antifungal agent 122 inhibits CYP3A4-M and CYP3A4-T enzyme activity with IC₅₀ values of 2.11, 4.53 µM. Antifungal agent 122 shows no cytotoxicity .

HY-155710

Antifungal agent 68	Fungal	Infection
Antifungal agent 68 (compound 10) is an antifungal agent against Candida and Cryptococcus gattii. Antifungal agent 68 inhibits fungal ergosterol biosynthesis, possibly by targeting lanosterol 14α-demethylase (CYP51). There is an interaction between the imidazole ring of antifungal agent 68 and the heme group of CYP51 .

HY-146427

Antifungal agent 29	Fungal	Infection
Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM) .

HY-155709

Antifungal agent 67	Fungal	Infection
Antifungal agent 67 (compound 9) is an imidazole antifungal agent that is effective against Candida. Antifungal agent 67 has a CC50 value of 33.6 μM on healthy neonatal rat cardiomyoblasts .

HY-169203

Antifungal agent 119	Fungal	Cancer
Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions. .

HY-155084

Antifungal agent 61	Fungal	Infection
Antifungal agent 61 (Compound 38) is an antifungal agent. Antifungal agent 61 inhibits V. mali with an EC₅₀ value of 0.50 mg/L. Antifungal agent 61 inhibits V. mali by causing cell deformation and contraction, reducing the number of intracellular mitochondria, thickening the cell wall, and increasing the permeability of the cell membrane .

HY-118847

Antifungal agent 86	Fungal	Infection
Antifungal agent 86 (Compound 41F5) is an antifungal agent. Antifungal agent 86 is highly active against Histoplasma yeast and Cryptococcus neoformans (MIC₅₀: 0.4-0.8 μM) .

HY-146464

Antifungal agent 30	Fungal	Infection
Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .

HY-147919

Antifungal agent 33	Fungal	Infection
Antifungal agent 33 (compound 4e) is a potent *antifungal* agent. Antifungal agent 33 exhibits remarkable antifungal activity against C. albicans, with a MIC of 16 μg/mL. Antifungal agent 33 shows potent inhibitory activity against Lanosterol 14α-demethylase (CYP51), with an IC₅₀ of 0.19 μg/mL .

HY-153620

Antifungal agent 55	Fungal	Infection
Antifungal agent 55 (compound A07) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 55 is more effective than Miconazole (HY-B0454). Antifungal agent 55 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .

HY-153622

Antifungal agent 57	Fungal	Infection
Antifungal agent 57 (compound A19) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 57 is more effective than Miconazole (HY-B0454). Antifungal agent 57 inhibits Candida albicans strains with MIC values of 0.5-2 μg/mL .

HY-153623

Antifungal agent 58	Fungal	Infection
Antifungal agent 58 (compound A21) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 58 is more effective than Miconazole (HY-B0454). Antifungal agent 58 inhibits Candida albicans strains with MIC values of 0.06-8 μg/mL .

HY-153619

Antifungal agent 54	Fungal	Infection
Antifungal agent 54 (compound A05) is a potent antifungal agent, against Fluconazole (HY-B0101)-resistant strains. Antifungal agent 54 is more effective than Miconazole (HY-B0454). Antifungal agent 54 inhibits Candida albicans strains with MIC values of 0.25-1 μg/mL .

HY-153618

Antifungal agent 53	Fungal	Infection
Antifungal agent 53 (A03) is a potent inhibitor of Candida albicans CYP51 with antifungal activity. Antifungal agent 53 prevents the formation of fungi biofilms. Antifungal agent 53 also exhibits good safety .

HY-176483

Antifungal agent 133	Fungal	Infection
Antifungal agent 133 (compound D2) is an orally active antifungal agent with a MIC₈₀ of 0.13 ug/mL against C.neoformans H99. Antifungal agent 133 can be used for study of cryptococcal meningitis .

HY-146023

Antifungal agent 27	Bacterial Fungal	Infection
Antifungal agent 27 (compound 7) is a antifungal agent. Antifungal agent 27 shows moderate antibacterial and weak antifungal activities against MRSA and C. albicans SS5314, with MIC values of 8 and 32 μg/mL, respectively .

Cat. No.	Product Name

HY-L048

Antifungal Compound Library

559 compounds

The high rates of morbidity and mortality caused by fungal infections are associated with the current limited antifungal arsenal and the high toxicity of the compounds. Additionally, identifying novel drug targets is challenging because there are many similarities between fungal and human cells. The most common antifungal targets include fungal RNA synthesis and cell wall and membrane components, though new antifungal targets are being investigated. Nonetheless, fungi have developed resistance mechanisms, such as overexpression of efflux pump proteins, overexpression and changes in drug targets and biofilm formation, emphasizing the importance of discovering new antifungal drugs and therapies. Due to the limited antifungal arsenal, researchers have sought to improve treatment via different approaches, such as the combination of antifungal drugs, development of new formulations for antifungal agents and modifications to the chemical structures of traditional antifungals, etc.

MCE offers a unique collection of 559 compounds with validated antifungal activities. MCE antifungal compound library is an effective tool for drug repurposing screening, combination screening and biological investigation.

HY-L938

Antifungal Lead-like compound library

8350 compounds

Currently,the incidence and mortality rates of clinical fungal infections remain high. Existing antifungal drugs are limited in variety and associated with numerous adverse effects, creating an urgent demand for the development of novel antifungal agents. Antifungal compound libraries can support the screening and development of new antifungal drugs.

The mechanisms of action of antifungal drugs cover key processes such as fungal cell membrane synthesis, cell wall synthesis, and cell division. They exert fungicidal or fungistatic effects by specifically targeting different molecular pathways. This library includes a variety of core analogs of antifungal drugs, making it adaptable to antifungal research in diverse scenarios. It can be used for the high-throughput screening of novel antifungal drug candidates, enabling the rapid identification of compounds with potential antifungal activity and facilitating the elucidation of drug-target interactions and resistance mechanisms. Additionally, it supports the screening of compounds and combinations that reverse drug resistance, thereby uncovering the novel antifungal potential of existing compounds.

The library comprises 8350 compounds with a well-defined screening strategy. The core sources of the compounds include analogs of known antifungal active moleculeswith a similarity score of ≥ 0.6 MCE has collected more than 500 antifungal molecules.All screened compounds conform to lead-like physicochemical properties, exhibiting both structural diversity and drug-like characteristics, and providing valuable support for the research and development of novel antifungal drugs.

Cat. No.	Product Name	Type

HY-B0450AG

Ciclopirox olamine

Ciclopirox ethanolamine; HOE 296

Fluorescent Dyes

Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

Cat. No.	Product Name	Type

HY-W027592

1H-1,2,4-Triazol-3-amine

Biochemical Assay Reagents

1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.

HY-W007626

3,5-Dimethoxybenzaldehyde	Biochemical Assay Reagents
3,5-Dimethoxybenzaldehyde is an *antifungal* agent. 3,5-Dimethoxybenzaldehyde exhibits antifungal activity against Saccharomyces cerevisiae cell wall integrity mutants (slt2Δ and bck1Δ) and Aspergillus fumigatus MAPK mutants (sakAΔ and mpkCΔ) .

HY-W016806

Sodium methylparaben, 99% 5+ Cited Publications Sodium methyl 4-hydroxybenzoate, 99%	Biochemical Assay Reagents
Sodium methylparaben, 99% (Sodium methyl 4-hydroxybenzoate, 99%) is an antifungal agent .

HY-W127452

Undecylenate sodium

Biochemical Assay Reagents

Undecylenate SodiumIt is an organic compound belonging to the class of carboxylates. It is formed by the reaction of undecylenic acid and sodium hydroxide. Undecylenate SodiumIt has a variety of applications in the cosmetic and personal care industries, especially as an antifungal agent in products such as face creams, lotions and shampoos. In addition, it can be used as a preservative in various formulations.

HY-W250119

Calcium disodium edetate hydrate

20+ Cited Publications

EDTA disodium calcium salt hydrate; Ethylenediaminetetraacetic acid disodium calcium salt hydrate

Biochemical Assay Reagents

Calcium disodium edetate hydrate (EDTA disodium calcium salt hydrate) is a metal chelator and antifungal agent. Calcium disodium edetate hydrate chelates Mn ²⁺, damages mitochondria, and interferes with carbohydrate metabolic pathways, particularly the synthesis of pyruvate in glycolysis. Calcium disodium edetate hydrate inhibits Penicillium digitatum and delays conidial germination. Calcium disodium edetate (hydrate) enhances the host defense system of citrus fruits. Calcium disodium edetate hydrate is applicable to research related to citrus green mold .

HY-159104

Cinnamon bark oil, from Cinnamonum zeylanicum Blume Cinnamomum Cassia oil	Biochemical Assay Reagents
Cinnamon bark oil, from Cinnamonum zeylanicum Blume is a antifungal agent against fungi causing respiratory tract mycoses .

HY-106333

Irtemazole R 60844	Biochemical Assay Reagents
Irtemazole is an orally active antifungal agent. Irtemazole possesses uricosuric effect. Irtemazole is used in the research for blastomycosis, histoplasmosis, and aspergillosis .

HY-W016806R

Sodium methylparaben (Standard) Sodium methyl 4-hydroxybenzoate (Standard)	Biochemical Assay Reagents
Sodium methylparaben (Standard) is the analytical standard of Sodium methylparaben. This product is intended for research and analytical applications. Sodium methylparaben (Sodium methyl 4-hydroxybenzoate) is an antifungal agent .

HY-B0450AG

Ciclopirox olamine

Ciclopirox ethanolamine; HOE 296

Biochemical Assay Reagents

HY-W027592R

1H-1,2,4-Triazol-3-amine (Standard)

Biochemical Assay Reagents

1H-1,2,4-Triazol-3-amine (Standard) is the analytical standard of 1H-1,2,4-Triazol-3-amine. This product is intended for research and analytical applications. 1H-1,2,4-Triazol-3-amine consists of a triazole ring system and an amino group attached to carbon atom 3. The compound has potential applications in various fields such as medicinal chemistry, agrochemicals and material science. In medicinal chemistry, 1H-1,2,4-Triazol-3-amine is used as a starting material for the synthesis of pharmaceutical compounds such as antifungal agents, anticancer agents, and enzyme inhibitors associated with cardiovascular disease. In agrochemicals, it can be used as a raw material for the synthesis of herbicides, fungicides and insecticides. Furthermore, 1H-1,2,4-Triazol-3-amine is used as a ligand in coordination chemistry and as a precursor for the production of new functional materials such as polymers and metal-organic frameworks.

Cat. No.	Product Name	Target	Research Area

HY-108954

A-30912A nucleus hydrochloride	Peptides	Infection
A-30912A nucleus hydrochloride is the product of Echinocandin B (ECB) deacylase-catalyzed antifungal agent A-30912A (HY-125723) .

HY-P0068

Aminocandin HMR 3270; IP960; NXL201	Fungal	Infection
Aminocandin (HMR 3270) is water-soluble *antifungal* agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0221

Amphotericin B Maximum Cited Publications 26 Publications Verification	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Antibiotic Bacterial Parasite
Amphotericin B is a polyene antifungal agent against a wide variety of *fungal* pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-17514

Itraconazole 20+ Cited Publications R51211	Microorganisms Source Classification	Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-B0133

Natamycin 5+ Cited Publications Pimaricin	Structural Classification Preservatives Anti-inflammation/Immunoregulatory Antifungal Classification of Application Fields Disease Research Endogenous metabolite Food Research Infection Microorganisms Macrolide Antibiotics Antibiotics Disease Research Fields Source Classification	Environmental Pollutants Antibiotic Endogenous Metabolite Fungal Bacterial
Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .

HY-33037

Phenazine-1-carboxylic acid	Infection Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Marine natural products Disease Research Fields Source Classification	Fungal
Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation .

HY-N4283

Coniferyl alcohol	Infection Monophenols Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate Fungal
Coniferyl alcohol is an orally active lignin biosynthesis intermediate and *antifungal* agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation .

HY-N1073

Wighteone 1 Publications Verification 6-Isopentenylgenistein; Erythrinin B	Leguminosae Genista ephedroides DC. Plants Isoflavones Source Classification	Apoptosis EGFR HSP ERK Akt
Wighteone (6-Isopentenylgenistein; Erythrinin B) is a prenylated isoflavone that acts as a HSP90/EGFR ^L858R/T790M inhibitor and antifungal agent. Wighteone reduces the expression level of HSP90, blocks EGF-induced phosphorylation of EGFR, and thereby inhibits the downstream ERK and AKT signaling pathways. Wighteone induces cell cycle redistribution, inhibits proliferation and triggers apoptosis in cancer cells. Wighteone can be isolated from Erythrina suberosa, and can also be induced to synthesize in Lotus japonicus under specific conditions. Wighteone can be used to study HER2-positive breast cancer, leukemia, non-small cell lung cancer with EGFR ^L858R/T790M mutation, and fungal infections .

HY-121388

Ledol (+)-Ledol	Structural Classification Terpenoids Sesquiterpenes Ericaceae Plants Rhododendron tomentosum Harmaja Source Classification	Fungal
Ledol ((+)-Ledol) is an antifungal agent isolated from the volatile oil components of Rhododendron tomentosum. Ledol also acts as an expectorant and antitussive, while it can cause adverse reactions such as dizziness, nausea and vomiting .

HY-B0914

10-Undecenoic acid,98% (stabilized with TBC) 2 Publications Verification Undecylenic acid	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Bacterial Fungal Proteasome Amyloid-β Reactive Oxygen Species (ROS)
10-Undecenoic acid (Undecylenic acid) is an *antifungal* agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-17578

Pneumocandin B0 L-688786	Infection Alkaloids Human Gut Microbiota Metabolites Microorganisms Pyrrole Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Drug Intermediate
Pneumocandin B0 (L-688786) is the precursor of the synthetic antifungal agent Cancidas (Caspofungin acetate) (HY-17006). Pneumocandin B0 can be isolated from fungus Glarea lozoyensis .

HY-B0914A

10-Undecenoic acid zinc salt 2 Publications Verification Zinc undecylenate	Infection Structural Classification Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Bacterial Amyloid-β Reactive Oxygen Species (ROS) Proteasome
10-Undecenoic acid zinc salt (Undecylenic acid zinc salt) is an *antifungal* agent. 10-Undecenoic acid zinc salt inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid zinc salt has neuroprotective effects. 10-Undecenoic acid zinc salt has anticancer effects on a variety of tumors. 10-Undecenoic acid zinc salt inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid zinc salt inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N2512

1-Monomyristin 1 Publications Verification	Infection Structural Classification Serenoa repens Classification of Application Fields Palmae Plants Disease Research Fields Steroids	Environmental Pollutants Endogenous Metabolite FAAH Autophagy Bacterial Fungal
1-Monomyristin acts as an insecticide, enzyme inhibitor, antibacterial and *antifungal* agent, with an IC₅₀ of 18 μM against rat FAAH and an IC₅₀ of 32 μM against rat MAGL. 1-Monomyristin inhibits 2-oleoylglycerol hydrolysis via MAGL. 1-Monomyristin suppresses the growth of Staphylococcus aureus, Aggregatibacter actinomycetemcomitans and Candida albicans. 1-Monomyristin is lethal to brine shrimp . 1-Monomyristin exhibits marginal cytotoxicity against prostate cancer cells. 1-Monomyristin is applicable to research related to bacterial infections, fungal infections, renal cancer, prostate adenocarcinoma and pancreatic cancer .

HY-W115529

Geranic acid Geranate; NSC 229335; GAGE	Structural Classification Ketones, Aldehydes, Acids Plants Lauraceae Litsea cubeba (Lour.) Pers. Source Classification	Environmental Pollutants Fungal Tyrosinase
Geranic acid (Geranate) acts as a tyrosinase inhibitor and antifungal agent, with an IC₅₀ value of 0.14-2.3 mM against mushroom tyrosinase. Geranic acid reduces the viability of human pancreatic cancer cells and B-lymphoma cells. Geranic acid inhibits mycelial growth of the maize pathogens Colletotrichum graminicola and Fusarium graminearum. Geranic acid is applicable to research related to fungal infections, pancreatic cancer and B-lymphoma .

HY-W357140

β-Phenylethyl β-D-glucoside Phenylethyl β-D-glucopyranoside	Piperaceae Piper crocatum Ruiz & Pav. Plants Saccharides Monosaccharides Source Classification	Fungal
β-Phenylethyl β-D-glucoside (Phenylethyl β-D-glucopyranoside) (Compound 7), a phenolic compounds, is an antifungal agent. β-Phenylethyl β-D-glucoside can be isolated from the leaves of Piper crocatum. β-Phenylethyl β-D-glucoside has antifungal activity against Candida albicans. β-Phenylethyl β-D-glucoside can be used for fungal infections research .

HY-W001251

3,5-Dimethoxybenzoic acid	Melia azedarach Linn. Classification of Application Fields Ketones, Aldehydes, Acids Plants Meliaceae Inflammation/Immunology Disease Research Fields Source Classification	Fungal Drug Intermediate
3,5-Dimethoxybenzoic acid is an aromatic organic acid and *antifungal* agent. 3,5-Dimethoxybenzoic acid can also be used as an intermediate for anticancer agents. 3,5-Dimethoxybenzoic acid can be isolated from the leaves of Melia azedarach. 3,5-Dimethoxybenzoic acid exhibits antifungal activity against A. rabiei with an MIC of 0.125 mg/mL. 3,5-Dimethoxybenzoic acid has anti-wrinkle, anti-inflammatory, antioxidant, and skin regeneration effects .

HY-N6829

Retusin Quercetin-3,3',4',7-tetramethylether	Flavonols Structural Classification Monophenols Flavonoids Entada phaseoloides (L.) Merr. Classification of Application Fields Labiatae Phenols Plants Inflammation/Immunology Disease Research Fields Source Classification	Tyrosinase Fungal SARS-CoV Apoptosis Reactive Oxygen Species (ROS)
Retusin (Quercetin-3,3',4',7-tetramethylether) is a tyrosinase inhibitor, with IC₅₀ values of 50.9 μM and 51.8 μM against mushroom and intracellular tyrosinase, respectively. Retusin also acts as a free radical scavenger, melanogenesis inhibitor, anti-apoptosis agent, neuroprotective agent, antiemetic, antifungal agent, and antiviral agent. Retusin scavenges ABTS• ⁺ and DPPH• free radicals. Retusin can be used in studies related to hyperpigmentation, vomiting, Aspergillus niger infection, and COVID-19 infection .

HY-W505771

Seselin	Flavonoids Ficus erecta Thunb. var. beecheyana (Hook.et Arn.) King Plants Moraceae Other Flavonoids Source Classification	Fungal
Seselin is an anticancer, antinociceptive, anti-inflammatory and antifungal agent. Seselin is orally active .

HY-N10418

Isorhapontin	Pinaceae Phenols Polyphenols Picea asperata Mast. Plants Source Classification	Fungal
Isorhapontin is an *antifungal* agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a K_i of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I .

HY-106784

Ajoene	Infection Natural Products Liliaceae Classification of Application Fields Plants Disease Research Fields A．Sativam L. var．Viviparum Regel Source Classification	Fungal Apoptosis
Ajoene, a garlic-derived compound, is an antithrombotic and *antifungal* agent. Ajoene inhibits proliferation and induces apoptosis of human leukaemia CD34-negative cells including HL-60, U937, HEL and OCIM-I. Anticancer activities .

HY-76200R

Voriconazole (Standard) UK-109496 (Standard)	Microorganisms Source Classification	Reference Standards Fungal Bacterial
Voriconazole (Standard) is the analytical standard of Voriconazole. This product is intended for research and analytical applications. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole *antifungal* agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .

HY-B0101R

Fluconazole (Standard) UK-49858 (Standard)	Microorganisms Source Classification	Reference Standards Fungal Antibiotic Bacterial
Fluconazole (Standard) is the analytical standard of Fluconazole. This product is intended for research and analytical applications. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .

HY-17514R

Itraconazole (Standard) R51211 (Standard)	Microorganisms Source Classification	Reference Standards Fungal Hedgehog Cytochrome P450 Autophagy Antibiotic Bacterial
Itraconazole (Standard) is the analytical standard of Itraconazole. This product is intended for research and analytical applications. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-N3968

Goniothalamin GTN; (R)-(+)-Goniothalamin	Structural Classification Natural Products Lythraceae Plants Lythrum salicaria L. Source Classification	Apoptosis Insecticide Bacterial Fungal Reactive Oxygen Species (ROS)
Goniothalamin (GTN) is a styryl lactone. Goniothalamin exhibits insecticidal, anti-tumor and antibacterial activities. Goniothalamin induces cell cycle arrest and apoptosis in tumor cells. Goniothalamin acts as a larvicide against Culex quinquefasciatus larvae and as a cytotoxin against brine shrimp larvae. Goniothalamin functions as an antibacterial agent against Gram-positive and Gram-negative bacteria, and also acts as an antifungal agent against pathogens including Candida albicans, Trichophyton rubrum and Trichophyton mentagrophytes. Goniothalamin is applicable to research related to breast cancer, lymphatic filariasis, bacterial infections and fungal infections .

HY-B0914R

10-Undecenoic acid (Standard) Undecylenic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Fungal Amyloid-β Reactive Oxygen Species (ROS) Proteasome Bacterial
10-Undecenoic acid (Standard) is the analytical standard of 10-Undecenoic acid. This product is intended for research and analytical applications. 10-Undecenoic acid (Undecylenic acid) is an *antifungal* agent. 10-Undecenoic acid inhibits Aβ oligomerization, scavenges ROS and inhibits μ-calpain activity. 10-Undecenoic acid has neuroprotective effects. 10-Undecenoic acid has anticancer effects on a variety of tumors. 10-Undecenoic acid inhibits C. albicans biofilm formation and MRSA infection. 10-Undecenoic acid inhibits quorum sensing signals of Bacillus subtilis and Pseudomonas aeruginosa .

HY-N4203

Isopropyl ferulate	Infection Monophenols Classification of Application Fields Simple Phenylpropanols Phenols Phenylpropanoids Plants Umbelliferae Kleinia odora (Forssk.) DC. Disease Research Fields Source Classification	Fungal
Isopropyl ferulate, isolated from Notopterygium incisum, is used in the reduction of pharmaceuticals, preparation of antifungal agents, cosmetics and as antioxidant agent and so forth .

HY-N8744

Vestitol (±)-Vestitol	Structural Classification Flavonoids Leguminosae Flavanols Trifolium arvense L. Plants Source Classification	Fungal
Vestitol ((±)-Vestitol) is an isoflavonoid phytoalexin and *Antifungal* agent. Vestitol can be isolated from the leaves of Trifolium arvense. Vestitol inhibits the mycelial growth of Helminthosporium carbonum with a ED₅₀ of 17 μg/mL. Vestitol can be used in the research of fungal infections (Helminthosporium carbonum-induced plant diseases) .

HY-B0133R

Natamycin (Standard) Pimaricin (Standard)	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Antifungal Macrolide Antibiotics Antibiotics Disease Research Endogenous metabolite Source Classification	Reference Standards Fungal Endogenous Metabolite Antibiotic Bacterial
Natamycin (Standard) is the analytical standard of Natamycin. This product is intended for research and analytical applications. Natamycin (Pimaricin) is a macrolide antibiotic agent produced by several Streptomyces strains. Natamycin inhibits the growth of fungi via inhibition of amino acid and glucose transport across the plasma membrane. Natamycin is a food preservative, an antifungal agent in agriculture, and is widely used for fungal keratitis research .

HY-N2646

5-Heptadec-cis-8-enylresorcinol	Phenols Polyphenols Proteaceae Plants Source Classification Hakea amplexicaulis R.Br.	Fungal
5-Heptadec-cis-8-enylresorcinol is a 5-alkylresorcinol that can be isolated from etiolated rice seedlings. 5-Heptadec-cis-8-enylresorcinol is an antifungal agent against the rice blast fungus. 5-Heptadec-cis-8-enylresorcinol mediates DNA relaxation .

HY-W010203

2-Decanone	Structural Classification Ketones, Aldehydes, Acids Humulus lupulus L. Plants Moraceae Source Classification	Fungal
2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables .

HY-W134163

(E)-2-Octenal trans-2-Octenal	Structural Classification Natural Products Vitis vinifera cv. Zalema Plants Vitaceae Source Classification	Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Phosphatase Pyruvate Kinase
(E)-2-Octenal is an *Antifungal* agent. (E)-2-Octenal disrupts cell membrane integrity and causes ROS accumulation. (E)-2-Octenal decreases the activities of phosphofructokinase and pyruvate kinase. (E)-2-Octenal inhibits Neofusicoccum parvum growth by disrupting mitochondrial energy metabolism. (E)-2-Octenal suppresses the growth of a Prochloraz (HY-B0845)-resistant Penicillium italicum strain. (E)-2-octenal exerts a broad-spectrum and potent inhibitory effect on various fungi, including Sclerotium rolfsii, Metarhizium anisopliae sensu lato, and Aspergillus flavus, etc. (E)-2-Octenal can be used for the research of citrus blue mold and mango stem-end rot .

HY-N3089

Phaseollidin	Leguminosae Phenols Polyphenols Plants Phaseolus vulgaris Linn. Source Classification	Fungal
Phaseollidin is an *antifungal* agent that can be isolated from Phaseolus vulgaris L. .

HY-N15738

(-)-Zonarol	Marine algae Marine natural products Phenols Polyphenols Source Classification	Fungal
(-)-Zonarol is an *antifungal* agent. (-)-Zonarol exhibits divergent translational potential. (-)-Zonarol is an isomer of Zonarol. Zonarol is a (-)-Yahazunol-related natural product .

HY-142003

27-O-Demethylrapamycin	Natural Products Microorganisms Source Classification	Fungal
27-O-Demethylrapamycin, a Rapamycin (HY-10219) derivative, is an antifungal agent. 27-O-Demethylrapamycin inhibits Candida albicans, Saccharomyces cerevisiae, and Fusarium oxysporum .

HY-N11772

Mutanocyclin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Fungal
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse .

HY-B0221R

Amphotericin B (Standard)	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Reference Standards Fungal Antibiotic Bacterial Parasite
Amphotericin B (Standard) is the analytical standard of Amphotericin B. This product is intended for research and analytical applications. Amphotericin B is a polyene antifungal agent against a wide variety of *fungal* pathogens. It binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

HY-N4283R

Coniferyl alcohol (Standard)	Structural Classification Monophenols Simple Phenylpropanols Phenols Phenylpropanoids Endogenous metabolite Source Classification	Reference Standards Drug Intermediate Fungal
Coniferyl alcohol is an orally active lignin biosynthesis intermediate and antifungal agent. Coniferyl alcohol specifically inhibits the growth of fungi (Verticillium longisporum). Coniferyl alcohol inhibits the growth of Nicotiana benthamiana seedlings. Coniferyl alcohol improves cardiac dysfunction in renovascular hypertension and cardiac inflammation .

HY-128478

Sordarin	Microorganisms Ketones, Aldehydes, Acids Source Classification	Fungal
Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex .

HY-N12621

Antifungal agent 91	Flavanonols Flavonoids Artocarpus elasticus Reinw. ex Blume Plants Moraceae Source Classification	Phosphatase
Antifungal agent 91(compound 1) is a dihydroflavonol that can be isolated from the leaves of Artocarpus elasticus. Antifungal agent 91 is a PTP1B inhibitor with an IC₅₀ value of 0.17 μM. Antifungal agent 91 has antifungal activity .

HY-125124

Chamaejasmenin D	Flavonoids Thymelaeaceae Stellera chamaejasme Linn. Plants Biflavones Source Classification	Fungal
Chamaejasmenin D is an antimitotic and *antifungal* agent .

HY-N0957

(±)-Pinoresinol	Structural Classification Melia azedarach L. Phenols Polyphenols Plants Meliaceae Source Classification	Fungal
(±)-Pinoresinol is a potent antifungal agent. (±)-Pinoresinol shows antifungal activity .

HY-N0954

(+)-Pinoresinol diacetate	other families Ketones, Aldehydes, Acids Adiantum capillus-veneris L. Plants Source Classification	Fungal
(+)-Pinoresinol diacetate is an antifungal agent that can be isolated from Sambucus williamsii .

HY-N10101

Eriobofuran	Monophenols Rosaceae Phenols Plants Source Classification Sorbus aucuparia Poir.	Fungal
Eriobofuran is an antifungal agent can be isolated from Sorbus aucuparia .

HY-126610

Dactylfungin A	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Dactylfungin A, an α-pyrone-containing antifungal agent found in Dactylaria parvispora.

HY-178255

Xanthochymol	Structural Classification Monophenols Guttiferae Phenols Plants Source Classification	Fungal Apoptosis
Xanthochymol is an antifungal agent found in Clusia rosea. Xanthochymol can induce fungal apoptosis .

HY-117496

Ampelopsin A	Polygonaceae Phenols Polyphenols Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Fungal
Ampelopsin A is a antifungal agent and can be isolated from the Vitis vinifera canes. Ampelopsin A shows neuroprotective effects .

HY-137794

Tetramethylkaempferol	Flavonoids Flavones Kaempferia parviflora Wall. ex Baker Plants Source Classification Zingiberaceae	Fungal
Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC₅₀ value of 17.63 µg/mL .

HY-N14250

Melithiazole C	Microorganisms Antibiotics Other Antibiotics Source Classification	Antibiotic Fungal
Melithiazol C is an antibiotic. Melithiazole C is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal agent .

HY-N16444

Sporminarin B	Natural Products Microorganisms Source Classification	Fungal Bacterial
Sporminarin B is an antibacterial and antifungal agent. Sporminarin B exhibits inhibitory activity against microorganisms such as Candida albicans and Staphylococcus aureus .

HY-N9378

3-Oxobetulin	Infection other families Antifungal Classification of Application Fields Antibiotics Disease Research Plants Disease Research Fields Other Antibiotics Source Classification	Fungal
3-Oxobetulin, an *antifungal* agent, shows antifungal activities against white rot fungus L. betulina and the brown rot fungus L. sulphureus .

HY-N12118

Piperanine	Natural Products Piperaceae Plants Piper retrofractum Vahl Source Classification	Fungal
Piperanine is an antifungal agent. Piperanine shows growth inhibition against the fungus Cladosporium claspoirioides. Piperanine can be isolated from the fruits of Piper retrofractum .

HY-152909

Nystatin A2	Microorganisms Antibiotics Other Antibiotics Source Classification	Fungal
Nystatin A2 is an active component of *antifungal* agent, Nystatin (HY-17409). Nystatin is an orally active polyene antifungal antibiotic effective against yeast and mycoplasma .

Cat. No.	Product Name	Chemical Structure

HY-12772S

Hydroxy Itraconazole-d8
Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-B1119S

Triclosan-d3
Triclosan-d₃ is the deuterium labeled Triclosan. Triclosan is an antibacterial and antifungal agent found in consumer products, including soaps, detergents, toys, and surgical cleaning treatments .

HY-76200S

Voriconazole-d3 2 Publications Verification
Voriconazole-d₃ is the deuterium labeled Voriconazole. Voriconazole (UK-109496) is a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. Voriconazole exerts its antifungal activity by inhibition of 14-α-lanosterol demethylation, which is mediated by fungal cytochrome P450 enzymes .

HY-17514S

Itraconazole-d5

Itraconazole-d₅ is the deuterium labeled Itraconazole. Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects .

HY-B0101S

Fluconazole-d4
Fluconazole-d₄ is the deuterium labeled Fluconazole. Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL .

HY-17514S1

Itraconazole-d3

Itraconazole-d₃ (R51211-d₃) is the deuterium labeled Itraconazole (HY-17514) . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.

HY-15660S

Efinaconazole-d4
Efinaconazole-d₄ is the deuterium labeled Efinaconazole. Efinaconazole (KP-103) is a triazole antifungal agent and againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively . Efinaconazole has a potent in vitro activity against fungal pathogens including dermatophytes, Candida and Malassezia species .

HY-17006S

Caspofungin-d4 diacetate
Caspofungin-d₄ (acetate) is the deuterium labeled Caspofungin diacetate . Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .

HY-17514S2

Itraconazole-d9

Itraconazole-d₉ is the deuterium labeled Itraconazole . Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC₅₀ of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor .

HY-23155S

2-Phenylethyl isothiocyanate-d5

2-Phenylethyl isothiocyanate-d₅ isothiocyanate-d₅ is the deuterium labeled 2-Phenylethyl isothiocyanate[1]. 2-Phenylethyl isothiocyanate is a potent antifungal agent. 2-Phenylethyl isothiocyanate significantly inhibited spore germination and mycelial growth of Alternaria alternata, with a MIC (minimum inhibitory concentration) of 1.22 mM. The antifungal effect of 2-Phenylethyl isothiocyanate against Alternaria alternata might be via reduction in toxin content and breakdown of cell membrane integrity[2][3].

HY-B0450S1

Ciclopirox-d11 sodium
Ciclopirox-d₁₁ (sodium) is deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

HY-B0101S1

Fluconazole-13C2,15N
Fluconazole-13C2,15N (UK-49858-13C2,15N) is the ¹³C and ¹⁵N labeled isotope of Fluconazole (HY-B0101). Fluconazole (UK-49858) is a triazole *antifungal* agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC₉₉s range from 0.20 μg/mL to 0.39 μg/mL .

HY-B0454S

Miconazole-d5
Miconazole-d₅ is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects .

HY-B0454S1

Miconazole-d5 nitrate
Miconazole-d₅ (nitrate) is the deuterium labeled Miconazole. Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects .

HY-B0454S2

Miconazole-d2
Miconazole-d₂ is the deuterium labeled Miconazole . Miconazole (R18134) is an imidazole antifungal agent. Miconazole also has antibacterial effects .

HY-17583S

Griseofulvin-d3
Griseofulvin-d₃ is the deuterium labeled Griseofulvin. Griseofulvin (Gris-PEG) is a spirocyclic fungal natural product used in treatment of fungal dermatophytes; Antifungal agent .

HY-B1151S

Climbazole-d4
Climbazole-d₄ is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450 .

HY-W725543

Chlorphenesin-d5
Chlorphenesin-d₅ is the deuterium labeled Chlorphenesin (HY-A0133). Chlorphenesin is a reversible antigen-associated immunosuppressant. Chlorphenesin is an antibacterial and antifungal agent used in numerous eye care cosmetics .

HY-B0454AS

Miconazole-d5 nitrate (2,4-Dichlorobenzyloxy-d5)
Miconazole-d₅ (nitrate) (2,4-Dichlorobenzyloxy-d₅) is the deuterium labeled Miconazole nitrate. Miconazole nitrate (R18134 nitrate) is an imidazole antifungal agent. Miconazole nitrate also has antibacterial effects .

HY-12772S3

Hydroxy Itraconazole-d6
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole *antifungal* agent.

HY-B0450S

Ciclopirox-d11
Ciclopirox-d₁₁ is the deuterium labeled Ciclopirox. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

HY-137989S

Voriconazole N-oxide-d3
Voriconazole N-oxide-d₃ (Voriconazole oxynitride-d₃) is deuterium labeled Voriconazole N-oxide. Voriconazole N-oxide (Voriconazole oxynitride) is a potent antifungal agent. Voriconazole N-oxide has phototoxicity and photocarcinogenicity. Voriconazole N-oxide does not sensitize keratinocytes to ultraviolet B (UVB) .

HY-17006AS

Caspofungin-d4
Caspofungin-d₄ (MK-0991-d₄; L-743872-d₄) is a deuterium labeled Caspofungin (HY-17006A). Caspofungin is a potent antifungal agent. Caspofungin inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan .

HY-114518S2

Butenafine-d4

Butenafine-d4 (KP363-d4) is the deuterium labeled Butenafine (HY-114518). Butenafine (KP363) is a potent and broad spectrum benzylamine antifungal agent . Butenafine inhibits fungal ergosterol biosynthesis at the point of squalene epoxidation, leading to a deficiency of the fungal cell membranes. Butenafine is effective against dermatophytes infections, such as ?tinea pedis, ?tinea cruris, tinea versicolor .

HY-12772S4

(2S)-Hydroxy Itraconazole-d8
(2S)-Hydroxy Itraconazole-d8 ((2S)-R-63373-d8) is the enantiomer of Hydroxy Itraconazole-d8 (R-63373-d8) (HY-12772S). Hydroxy Itraconazole-d₈ is the deuterium labeled Hydroxy Itraconazole (HY-12772). Hydroxy Itraconazole is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-174394S

CYP51-IN-25
CYP51-IN-25 is a orally active broad spectrum antifungal agent with the MIC₈₀ of 0.00625-0.05 μg/mL. is a CYP51-IN-25 is a deuterated compound with antibiotic properties. CYP51-IN-25 can inhibit the fungal CYP51 enzyme, block ergosterol synthesis, and disrupt cell membrane integrity. CYP51-IN-25 can be used for research on *fungal* infections.

HY-B0885S

Econazole-d6

Econazole-d₆ ((±)-Econazol-d₆) is the deuterium labeled Econazole (HY-B0885). Econazole is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage .

HY-17395AS1

Terbinafine-d3

Terbinafine-d₃ (TDT 067-d₃) is deuterium labeled Terbinafine. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a K_i of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria . Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W021008S

Sotolone-d2

Sotolone-d₂ (Dimethylhydroxyfuranone-d₂) is deuterated labeled Sotolone. Sotolone is an activator of the human olfactory receptor OR8D1. Sotolone activates the human olfactory receptor OR8D1, with EC₅₀ values of 84.98 μM and 167.2 μM for its S-enantiomer and R-enantiomer, respectively. Sotolone has unique aroma profiles: (R)-sotolone exhibits smoky, burnt, herbal and grassy notes; (S)-sotolone presents sweet, milky, sour and nutty notes. Sotolone also acts as an antifungal agent, showing moderate inhibitory activity against Magnaporthe oryzae in vitro .

HY-17579S

Micafungin-d11 ammonium
Micafungin-d₁₁ ammonium (FK463-d₁₁ ammonium) is the deuterium labeled Micafungin ammonium. Micafungin (FK463) is an *antifungal* agent and can inhibit β-1,3-glucan synthase. Micafungin inhibits 1,3-β-glucan biosynthesis in fungal cell walls. Micafungin can be used for the research of fungal infection, such as candida infections and aspergillosis .

HY-W010203S1

2-Decanone-d5-1

2-Decanone-d₅-1 is the deuterium labeled 2-Decanone (HY-W010203). 2-Decanone is an antifungal agent. 2-Decanone inhibits pathogen mycelial growth, spore germination, and appressorium formation. 2-Decanone downregulates spore germination-related genes (MfBmp1) and penetration structure formation genes (MfPls1), inducing reactive oxygen species (ROS) accumulation to trigger mitochondrial damage and subsequent spore apoptosis. 2-Decanone is promising for research of postharvest disease control in fruits and vegetables .

Cat. No.	Product Name		Classification

HY-148921

SDH-IN-2		Alkynes
SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC₅₀ values of 3.82-9.81 μg/mL for all the fungi . SDH-IN-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-169203

Antifungal agent 119		Alkynes
Antifungal agent 119 (compund T23) is an antifungal agent that targets type I reduced NADH oxidoreductase. Antifungal agent 119 carries an azide group and can be used for click chemistry reactions. .

Cat. No.	Product Name		Classification

HY-177849

Liposomal Amphotericin B Amphotericin B liposome		Liposome
Liposomal Amphotericin B is a liposome-encapsulated form of Amphotericin B (HY-B0221). Amphotericin B is a polyene antifungal agent against a wide variety of fungal pathogens. Amphotericin B binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death. Liposomal Amphotericin B can significantly reduce the toxicity of Amphotericin B.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0450AG

Ciclopirox olamine Ciclopirox ethanolamine; HOE 296	Bacterial Fungal Ferroptosis	Infection
Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic .

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