2. Metabolic Enzyme/Protease Anti-infection Others
  3. HIF/HIF Prolyl-Hydroxylase EBV Drug Intermediate
  4. mCPX

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX) (HY-B0450A). CPX exhibits bacteriostatic and iron-chelating activities, while mCPX enhances the iron stability of CPX. mCPX inherits the core mechanism pathway of CPX and can induce EBV lytic reactivation in EBV+ gastric cancer cells via the hypoxia pathway (HIF‑1α). mCPX is applicable to research related to EBV-positive gastric cancer.

For research use only. We do not sell to patients.

mCPX

mCPX Chemical Structure

CAS No. : 1351572-56-9

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mCPX Related Antibodies

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Description

mCPX is a prodrug of the antifungal agent Ciclopirox olamine (CPX) (HY-B0450A). CPX exhibits bacteriostatic and iron-chelating activities, while mCPX enhances the iron stability of CPX. mCPX inherits the core mechanism pathway of CPX and can induce EBV lytic reactivation in EBV+ gastric cancer cells via the hypoxia pathway (HIF‑1α). mCPX is applicable to research related to EBV-positive gastric cancer[1].

In Vitro

mCPX induces EBV lytic cycle in SNU719 and AGSBX1 EBV+ gastric cancer cell lines with activity comparable to CPX, and has significantly greater resistance to iron-mediated inactivation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

mCPX Related Antibodies
Parmacokinetics
Species Dose Route T1/2 Tmax Cmax AUC AUC0-∞ MRT Vd CL
Rat[1] 14 mg/kg i.p. 10.88 h 0.67 h 3085.04 μg/L 9195.38 μg/L·h 9455.28 μg/L·h 6.67 h 23.25 L/kg 1.48 L/h/kg
Rat[1] 14 mg/kg i.g. 5.01 h 1.50 h 511.88 μg/L 4332.53 μg/L·h 4350.86 μg/L·h 6.05 h 23.25 L/kg 3.22 L/h/kg
In Vivo

mCPX exhibits superior in vivo antitumor activity to CPX in the SNU719 xenograft mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

249.31

Formula

C14H19NO3
CAS No.
SMILES

O=C(C)ON(C(C1CCCCC1)=CC(C)=C2)C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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mCPX Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

mCPX1351572-56-9HIF/HIF Prolyl-HydroxylaseEBVDrug IntermediateHypoxia-inducible factorsHIFsHIF-PHEpstein-Barr VirusDrug IintermediateEBV+ gastric cancer cellsepstein-barr virus+ gastric cancerEBV lytic cycleSNU719EBV lytic reactivationAGSBX1Inhibitorinhibitorinhibit

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