Climbazole-d4
Based on 1 Customer Validation
Climbazole-d4 is the deuterium labeled Climbazole. Climbazole (BAY-e 6975) is a potent antifungal agent. Climbazole also is a potent inducer of rat hepatic cytochrome P450.
For research use only. We do not sell to patients.
- Purity: 99.91%
- CAS No.: 1185117-79-6
- Formula: C15H13D4ClN2O2
- Molecular Weight:296.79
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1185117-79-6
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Unlabeled Cas 38083-17-9
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Appearance Solid
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Molecular Weight 296.79
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Formula C15H13D4ClN2O2
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Color White to off-white
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SMILES
ClC(C([2H])=C1[2H])=C([2H])C([2H])=C1OC(N2C=CN=C2)C(C(C)(C)C)=O
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Synonyms
BAY-e 6975-d4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (336.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Amrita Datta, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [Content Brief]
[3]. Y Kobayashi, et al. Climbazole is a new potent inducer of rat hepatic cytochrome P450. J Toxicol Sci. 2001 Aug;26(3):141-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3694 mL | 16.8469 mL | 33.6939 mL | 84.2346 mL |
| 5 mM | 0.6739 mL | 3.3694 mL | 6.7388 mL | 16.8469 mL | |
| 10 mM | 0.3369 mL | 1.6847 mL | 3.3694 mL | 8.4235 mL | |
| 15 mM | 0.2246 mL | 1.1231 mL | 2.2463 mL | 5.6156 mL | |
| 20 mM | 0.1685 mL | 0.8423 mL | 1.6847 mL | 4.2117 mL | |
| 25 mM | 0.1348 mL | 0.6739 mL | 1.3478 mL | 3.3694 mL | |
| 30 mM | 0.1123 mL | 0.5616 mL | 1.1231 mL | 2.8078 mL | |
| 40 mM | 0.0842 mL | 0.4212 mL | 0.8423 mL | 2.1059 mL | |
| 50 mM | 0.0674 mL | 0.3369 mL | 0.6739 mL | 1.6847 mL | |
| 60 mM | 0.0562 mL | 0.2808 mL | 0.5616 mL | 1.4039 mL | |
| 80 mM | 0.0421 mL | 0.2106 mL | 0.4212 mL | 1.0529 mL | |
| 100 mM | 0.0337 mL | 0.1685 mL | 0.3369 mL | 0.8423 mL |
Climbazole-d4 Related Classifications
HY-B1151S Related Classifications
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