P163-0892

Cat. No.: HY-150972: FAQs
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P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration.

For research use only. We do not sell to patients.

P163-0892 Chemical Structure

CAS No. : 1574576-45-6

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Description

P163-0892 is a potent and selective antifungal agent against Cryptococcus species. P163-0892 is predicted to show medium BBB penetration^[1].

In Vitro

P163-0892 (0-32 μg/mL; 48 h) shows antifungal activity with a MIC of 0.25 μg/mL and 0.5 μg/mL against Cryptococcus neoformans and Cryptococcus gattii, respectively^[1].
P163-0892 has good aqueous solubility^[1].
P163-0892 has no cytotoxicity and no obvious cardiotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

P163-0892 (10 mg/kg; 5 days) significantly extends the survival of larvae infected with either C. neoformans or C. gattii^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wax moth larva infected with C. neoformans H99 or C. gattii WM178^[1]
Dosage:	10 mg/kg
Administration:	5 days
Result:	Increased the survival rate of larvae.

Animal Model:

Male Sprague–Dawley rats weighing 200–250 g^[1]

Dosage:

2 mg/kg or 5 mg/kg

Administration:

Intravenous or oral administration (Pharmacokinetic Analysis)

Result:

Pharmacokinetic Parameters of P163-0892^a^[1]

route	dose (mg/kg)	T_1/2 (h)	T_max (h)	AUC_0-inf (h•ng/mL)	Cl (mL/h/kg)	MRT_0-t (h)	Vd_ss (L/kg)	BA (%)
iv	2 mg/kg	7.61		749	172	2.63	7.12
po	5 mg/kg	15.3	3.17	NR		3.83	NR	0.8

^aAbbreviations: iv, intravenous; po, per os; T_1/2, half-life elimination in hours; T_max, time of maximal concentration in hours; AUC, area under the curve; Cl, clearance; MRT, mean residence time; V_dss, volume of distribution at the steady state; BA, bioavailability; NR, not reportable; n = 3.

Molecular Weight

356.44

Formula

C₁₉H₂₀N₂O₃S

CAS No.

1574576-45-6

SMILES

O=C(C1=C(O)C2=C(C=CS2)N(CC3=CC=CC=C3)C1=O)NCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Li L, et al. Discovery of Novel 7-Hydroxy-5-oxo-4,5-dihydrothieno[3,2-b]pyridine-6-carboxamide Derivatives with Potent and Selective Antifungal Activity against Cryptococcus Species. J Med Chem. 2022 Aug 3. [Content Brief]

P163-0892 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

P163-08921574576-45-6FungalCryptococcus neoformansCryptococcus gattiihepatotoxicitywax moth larvaInhibitorinhibitorinhibit

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