Antifungal agent 153
Antifungal agent 153, a derivative of Blasticidin S (HY-103401A), is an antibacterial agent. Antifungal agent 153 retains the antibacterial activity of Blasticidin S, exhibits potent inhibitory effects against multidrug-resistant Gram-positive bacteria, and significantly reduces mammalian cytotoxicity. Antifungal agent 153 can be used in studies related to bacterial infections.
For research use only. We do not sell to patients.
- Formula: C36H47N11O7
- Molecular Weight:745.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Antifungal agent 153 (Compound 40) exhibits significant antimicrobial activity against a variety of Gram-positive pathogens, with an MIC of 16 μg/mL against MRSA USA300, MRSE 35984, E. faecalis 29212, and VRE NR-31972; it also shows activity against the Gram-negative K. pneumoniae, with an MIC of 86 μg/mL[1].
Antifungal agent 153 exhibits significantly reduced cytotoxicity against mammalian cells, with a CC50 value greater than 256 μg/mL[1].
Antifungal agent 153 (5×-10× MIC; 24 h) exhibits bactericidal activity against MRSA USA300, enabling complete bacterial eradication[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 745.83
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Formula C36H47N11O7
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SMILES
N[C@@](CO)(C(NC1=CC=C(C(NC2=NC(N(C=C2)[C@@H](C=C[C@@H]3NC(C[C@H](CCN(C(N)=N)C)N)=O)O[C@@H]3C(NCCC4=CC=CC=C4)=O)=O)=O)C=C1)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 153 Related Classifications
HY-181264 Related Classifications
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- Antifungal agent 153
- Antifungal agent153
- Antifungal agent-153
- vancomycin-resistant enterococci
- Enterococcus faecalis
- Gram-positive pathogens
- MRSA USA-300
- Klebsiella pneumoniae
- bacterial infections
- bacterial ribosomes
- Gram-negative pathogens
- eukaryotic ribosomal protein L10
- mammalian cells
- Inhibitor
- inhibitor
- inhibit