Antifungal agent 153 

Antifungal agent 153, a derivative of Blasticidin S (HY-103401A), is an antibacterial agent. Antifungal agent 153 retains the antibacterial activity of Blasticidin S, exhibits potent inhibitory effects against multidrug-resistant Gram-positive bacteria, and significantly reduces mammalian cytotoxicity. Antifungal agent 153 can be used in studies related to bacterial infections^[1].

Antifungal agent 153 (Compound 40) exhibits significant antimicrobial activity against a variety of Gram-positive pathogens, with an MIC of 16 μg/mL against MRSA USA300, MRSE 35984, E. faecalis 29212, and VRE NR-31972; it also shows activity against the Gram-negative K. pneumoniae, with an MIC of 86 μg/mL^[1].
Antifungal agent 153 exhibits significantly reduced cytotoxicity against mammalian cells, with a CC₅₀ value greater than 256 μg/mL^[1].
Antifungal agent 153 (5×-10× MIC; 24 h) exhibits bactericidal activity against MRSA USA300, enabling complete bacterial eradication^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

745.83

C₃₆H₄₇N₁₁O₇

N[C@@](CO)(C(NC1=CC=C(C(NC2=NC(N(C=C2)[C@@H](C=C[C@@H]3NC(C[C@H](CCN(C(N)=N)C)N)=O)O[C@@H]3C(NCCC4=CC=CC=C4)=O)=O)=O)C=C1)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Gannett C, et al. Structure-Guided Semisynthesis of Blasticidin S-Amicetin Chimeras as Selective Ribosome Inhibitors. J Am Chem Soc. 2026;148(3):2963-2971.  [Content Brief]