Icofungipen (Synonyms: BAY 10-8888; PLD 118)

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Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection.

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Icofungipen Chemical Structure

CAS No. : 198022-65-0

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Description	Icofungipen is an orally active antifungal agent. Icofungipen is the representative of beta amino acids, is toxic against Candida species. Icofungipen protects infected mice survival from C. albicans infection^[1].
In Vitro	Icofungipen shows inhibitory effect on Candida species with MIC values of 16-64 μg/mL after 24-48 h^[1]. Icofungipen shows MIC₉₀ values of 8-32 μg/mL for 90% C. albicans^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Icofungipen Related Antibodies
In Vivo	Icofungipen (5-25 mg/kg; po; twice daily for 7 days) shows a dose-dependent protection against clinical isolates of C. albicans in a lethal model of infection in mice^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	141.17
Formula	C₇H₁₁NO₂
CAS No.	198022-65-0
SMILES	OC([C@@H]1CC(C[C@@H]1N)=C)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Hasenoehrl A, et al. In vitro activity and in vivo efficacy of icofungipen (PLD-118), a novel oral antifungal agent, against the pathogenic yeast Candida albicans. Antimicrob Agents Chemother. 2006 Sep;50(9):3011-8. [Content Brief]

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Icofungipen198022-65-0BAY 10-8888 PLD 118PLD118PLD 118PLD-118FungalInhibitorinhibitorinhibit

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Icofungipen (Synonyms: BAY 10-8888; PLD 118)

Icofungipen Related Antibodies

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