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  2. Bacterial Fungal
  3. Antifungal agent 38

Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents.

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Antifungal agent 38 Chemical Structure

Antifungal agent 38 Chemical Structure

CAS No. : 2833772-94-2

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Description

Antifungal agent 38 is a geterocyclic disulfide, an antifungal and antibacterial agent. Antifungal agent 38 induces the shrinkage of hyphae, disrupts the integrity of the plasma membrane, and causes the damage and leakage of cell contents[1].

In Vitro

Antifungal agent 38 (50 μg/mL) shows anti-fungal activity against 10 pathogenic fungi with inhibition rates of 56.57% (R. solani), 100% (S. sclerotiorum), 55.09% (B. cinerea), 71.23% (F. graminearum), 37.32% (M. oryzae), 50.87% (P. capsici), 100% (A. flavus), 59.75% (P. expansum), 100% (M. fructicola), 65.78% (R. stolonifer), respectively[1].
Antifungal agent 38 (5 μg/mL) damages plasma membrane integrity of M. fructicola[1].
Antifungal agent 38 (100 μg/mL) displays excellent anti-bacterial activity against X. oryzae accc 11602, X. axonpodis[1].
Antifungal agent 38 inhibits fungus growth with EC50s of 17.09 μg/mL (R. solani), 6.34 μg/mL (S. sclerotiorum), 25.24 μg/mL (F. graminearum), >10 μg/mL (A. flavus), 10.42 μg/mL (M. fructicola), 45.71 μg/mL (B. cinerea), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: M. fructicola
Concentration: 10, 25, 50 μg/mL
Incubation Time: 2, 4, 6 days
Result: Inhibited M. fructicola growth.
In Vivo

Antifungal agent 38 (compound S8) (200 μg/mL) displays equivalent curative and higher protective effects as the positive drug Thiophanate-Methyl (HY-B0842) in vivo[1].
Antifungal agent 38 (50, 100, 200 μg/mL, 30 mL; sprinkling) applies on pears and inhibits M. fructicola growth in vivo[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

200.32

Formula

C8H12N2S2

CAS No.
SMILES

CC(CSSC1=NC=CC=N1)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Antifungal agent 38 Related Classifications

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Help & FAQs
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antifungal agent 38
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HY-151284
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