Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic.
For research use only. We do not sell to patients.
- CAS No.: 41621-49-2
- Formula: C14H24N2O3
- Molecular Weight:268.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
>40 μM
Compound: CPX.Olamine
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Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
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[PMID: 31910018] |
| HepG2 | IC50 |
>100 μM
Compound: 92125547
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HARVARD: Cytotoxicity in HepG2 cell line
HARVARD: Cytotoxicity in HepG2 cell line
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[PMID: 22586124] |
| HepG2 | IC50 |
1.05 μM
Compound: 92125547
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HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
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[PMID: 22586124] |
| MRC5 | IC50 |
23.47 μM
Compound: CPX.Olamine
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
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[PMID: 31910018] |
| SH-SY5Y | IC50 |
>100 μM
Compound: CPX.Olamine
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Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
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[PMID: 31910018] |
In a study conducted to further elucidate Ciclopirox GMP's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that Ciclopirox GMP may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport[2].
Ciclopirox GMP is a broad-spectrum antifungal with anti-inflammatory properties effective against the yeast implicated in seborrhoeic dermatitis, Malassezia spp[3].
Ciclopirox (olamine) (0.9 μM, 24 h) protects human iPSC-derived RPE cells exposed to TBHP-induced cell from oxidative damage[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:iPSC-derived RPE cells
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Concentration:0.9 μM
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Incubation Time:24 h
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Result:Protected human iPSC-derived RPE cells exposed to TBHP-induced cell death.
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Cell Line:iPSC-derived RPE cells
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Concentration:0.9 μM
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Incubation Time:24 h
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Result:Expressed RPE markers (RPE65, BEST1, MITF).
Chemical Information
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CAS No. 41621-49-2
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Molecular Weight 268.35
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Formula C14H24N2O3
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SMILES
O=C1C=C(C)C=C(C2CCCCC2)N1O.NCCO
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Synonyms
Ciclopirox ethanolamine (GMP); HOE 296 (GMP)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Niewerth M, et al. Ciclopirox olamine treatment affects the expression pattern of Candida albicans genes encoding virulence factors, iron metabolism proteins, and drug resistance factors. Antimicrob Agents Chemother. 2003 Jun;47(6):1805-17. [Content Brief]
[2]. Cai H, et al. High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD. Exp Eye Res. 2019 Aug;185:107641. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Ciclopirox olamine (GMP) Related Classifications
HY-B0450AG Related Classifications
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