Antifungal agent 72
Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research.
For research use only. We do not sell to patients.
- CAS No.: 3032485-62-1
- Formula: C13H14N4OS
- Molecular Weight:274.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Pdr1-KIX interaction[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
>83 μM
Compound: B8
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Cytotoxicity against human HUVEC cells incubated for 48 hrs by CCK-8 assay
Cytotoxicity against human HUVEC cells incubated for 48 hrs by CCK-8 assay
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[PMID: 37584282] |
Chemical Information
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CAS No. 3032485-62-1
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Molecular Weight 274.34
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Formula C13H14N4OS
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SMILES
NC1=CC(N(N1)C(NC2=CC3=C(CCC3)C=C2)=S)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antifungal agent 72 Related Classifications
HY-155198 Related Classifications
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