3032485-62-1
3032485-62-1
Chemical Structure
Antifungal agent 72
- CAS No.: 3032485-62-1
- Formula:C13H14N4OS
- Molecular Weight:274.34
InChIKey: RKDJDORYIGWQPB-UHFFFAOYSA-N
SMILES: NC1=CC(N(N1)C(NC2=CC3=C(CCC3)C=C2)=S)=O
Biological Activity: Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research[1].
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Antifungal agent 72 | Antifungal agent 72 (Compound B8) is a potent antifungal agent. Antifungal agent 72 suppresses the function of efflux pump and down-regulates the resistance-associated genes through blocking the Pdr1-KIX interaction (Ki: 11.7 μM). Antifungal agent 72 is active against Fluconazole (HY-B0101)-resistant with a MIC value of 63 ng/mL, and shows synergistic inhibitory activity with Fluconazole. Antifungal agent 72 can be used for C. glabrata infection research. | |||||||||||||||||||||
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