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Cat. No.: HY-149822

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Antifungal agent 51

Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity.

For research use only. We do not sell to patients.

CAS No.: 2896209-47-3
Formula: C₁₈H₁₆FN₅OS
Molecular Weight:369.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antifungal agent 51 Chemical Structure

CAS No.: 2896209-47-3

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Sample (0.1mg)

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(In Japan)

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

In Vitro

Antifungal agent 51 has potent antifungal activity, especially against Candida albicans FDC 151, Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and against Candida albicans CMRC 19 and Candida glabrata FDC 192 with MIC value of 0.125 μg/mL, against Candida albicans CMRC 192, with MIC value of 0.25 μg/mL, against Candida glabrata CMRC 89, with MIC value of 1 μg/mL^[1].
Antifungal agent 51 (6.25, 12.5, 25 μg/mL; 48 h) partially affects the viability of cell lines even at relatively high concentration of 25 μg/mL in BEAS-2B and HepG2 cells ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

BEAS-2B and HepG2 cells
Concentration:

6.25, 12.5, and 25 μg/mL
Incubation Time:

48 h
Result:

Partially affected the viability of cell lines even at relatively high concentration of 25 μg/mL in BEAS-2B and HepG2 cells

Chemical Information

CAS No. 2896209-47-3
Molecular Weight 369.42
Formula C₁₈H₁₆FN₅OS
SMILES

FC1=CC=C(C(CSC2=NC3=C(N2)C=CC=C3)(CN4N=CN=C4)O)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ghobadi E, et al. Design, synthesis and biological activity of hybrid antifungals derived from fluconazole and mebendazole. Eur J Med Chem. 2023 Mar 5;249:115146. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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