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  3. Antifungal agent 25

Antifungal agent 25 

Cat. No.: HY-143406
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Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo.

For research use only. We do not sell to patients.

Antifungal agent 25 Chemical Structure

Antifungal agent 25 Chemical Structure

CAS No. : 2566522-50-5

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Description

Antifungal agent 25 is a potent broad-spectrum antifungal agent. Antifungal agent 25 shows antifungal effect against Candida albicans and fluconazole-resistant strain of Candida albicans. Antifungal agent 25 stable metabolic property in vivo[1].

In Vitro

Antifungal agent 25 (compound A31) shows antifungal effect with MIC values of <0.03, <0.03, <0.03, 0.25, 0.5 µg/mL for Candida albicans (SC5314), Candida albicans ((GIM 2.194), Cryptococcus neoformans (GIM 2.209), Candida tropicalis (GIM 2.183), Aspergillus fumigatus (cgmcc 3.7795), respectively[1].
Antifungal agent 25 shows moderate antifungal activity with MIC values of 0.5, >64 µg/mL for strain CaR (fluconazole-resistant strain of Candida albicans) and strain 17# (fluconazole and itraconazole resistant strain of Candida albicans), respectively[1].
Antifungal agent 25 (0.015 mg/mL) blocks the biosynthesis of ergosterol by inhibiting the key enzyme lanosterol 14a-demethylase (CYP51)[1].
Antifungal agent 25 shows less likely to produce drug-drug interactions with IC50s of 4.47, 2.87, 1.04, 31.3, 10.1 µM for α-naphthoflavone (CYP1A2), sulfaphenazole (CYP2C9), ticlopidine (CYP2C19), quinidine (CYP2D6), and ketoconazole (CYP3A4), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Antifungal agent 25 (2 mg/kg; i.v.) exhibits stable metabolic property in SD rats[1].
Pharmacokinetic Parameters of Antifungal agent 25 in SD rats[1].

dose(mg/kg) C0(ng/mL) T1/2(h) Vdss(L/kg) Cl (mL/min/kg) AUC0-last (ng·h/mL) AUC0-inf (ng·h/mL)
2 mg/kg 482±108 3.34±2.37 10.3±3.12 69.4±18.8 483±137 5.5±136
SD rats; 2 mg/kg; i.v.[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SD rats[1]
Dosage: 2 mg/kg
Administration: I.v.
Result: Exhibited stable metabolic property in SD rats.
Molecular Weight

412.87

Formula

C20H14ClFN4OS

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Antifungal agent 25
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