Chitin synthase inhibitor 12
Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs).
For research use only. We do not sell to patients.
- CAS No.: 2725075-05-6
- Formula: C23H21ClFN3O5
- Molecular Weight:473.88
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 0.16 mM (chitin synthase)[1]
MIC: 64 μg/mL (C. albicans); 16 μg/mL (A. flavus); 64 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)[1]
Chitin synthase inhibitor 12 (compound 9t) (300 ug/mL) has good inhibitory activity against chitin synthase with an IC50 value of 0.16 mM[1].
Chitin synthase inhibitor 12 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 16 μg/mL, 64 μg/mL and 64 μg/mL, respectively[1].
Chitin synthase inhibitor 12 has broad-spectrum antifungal activity in vitro and has additive or synergistic effects combined with fluconazole[1].
Chitin synthase inhibitor 12 is related to the disruption of cell wall architecture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2725075-05-6
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Molecular Weight 473.88
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Formula C23H21ClFN3O5
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SMILES
O=C(NC1=CC=C(F)C(Cl)=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Chitin synthase inhibitor 12 Related Classifications
HY-151422 Related Classifications
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