2725075-05-6
Chemical Structure
Chitin synthase inhibitor 12
- No. CAS: 2725075-05-6
- Formula:C23H21ClFN3O5
- Molecular Weight:473.88
IUPAC Name: (E)-N-(3-chloro-4-fluorophenyl)-4-(6-methoxy-2-oxo-1,2-dihydrospiro[benzo[d][1,3]oxazine-4,4'-piperidin]-1'-yl)-4-oxobut-2-enamide
InChIKey: PVEZFCKVQQJBTM-VOTSOKGWSA-N
SMILES: O=C(NC1=CC=C(F)C(Cl)=C1)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
Biological Activity: Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs)[1].
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Chitin synthase inhibitor 12 | Chitin synthase inhibitor 12 is a chitin synthase inhibitor. Chitin synthase inhibitor 12 shows excellent inhibitory activity with an IC50 value of 0.16 mM. Chitin synthase inhibitor 12 also is a broad-spectrum antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 12 can be used for the research of invasive fungal infections (IFIs). | |||||||||||||||||||||
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