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Cat. No.: HY-151420

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Chitin synthase inhibitor 10

Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC₅₀ value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs).

For research use only. We do not sell to patients.

CAS No.: 2725075-01-2
Formula: C₂₄H₂₃Br₂N₃O₆
Molecular Weight:609.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Chitin synthase inhibitor 10 Chemical Structure

CAS No.: 2725075-01-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.11 mM (chitin synthase)^[1]
MIC: 64 μg/mL (C. albicans); 256 μg/mL (A. flavus); 128 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)^[1]

In Vitro

Chitin synthase inhibitor 10 (compound 9o) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC₅₀ value of 0.11 mM^[1].
Chitin synthase inhibitor 10 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 256 μg/mL, 128 μg/mL and 64 μg/mL, respectively^[1].
Chitin synthase inhibitor 10 is related to the disruption of cell wall architecture^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2725075-01-2
Molecular Weight 609.26
Formula C₂₄H₂₃Br₂N₃O₆
SMILES

O=C(NC1=C(Br)C=C(OC)C=C1Br)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yajie Xu, et al. Spiro[benzoxazine-piperidin]-one derivatives as chitin synthase inhibitors and antifungal agents: Design, synthesis and biological evaluation. Eur J Med Chem. 2022 Aug 31;243:114723. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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