Chitin synthase inhibitor 10
Chitin synthase inhibitor 10 is a chitin synthase inhibitor. Chitin synthase inhibitor 10 shows excellent chitin synthase inhibitory activity with an IC50 value of 0.11 mM. Chitin synthase inhibitor 10 also is an antifungal agent and has significantly antifungal activity against drug-resistant fungal variants, such as C. albicans and C. neoformans. Chitin synthase inhibitor 10 can be used for the research of invasive fungal infections (IFIs).
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- CAS. Nr.: 2725075-01-2
- Formel: C24H23Br2N3O6
- Molecular Weight:609.26
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.11 mM (chitin synthase)[1]
MIC: 64 μg/mL (C. albicans); 256 μg/mL (A. flavus); 128 μg/mL (A. fumigatus); 64 μg/mL (C. neoformans)[1]
In Vitro
Chitin synthase inhibitor 10 (compound 9o) (300 ug/mL) has good inhibitory activity against chitin synthase with with an IC50 value of 0.11 mM[1].
Chitin synthase inhibitor 10 has antifungal activity for C. albicans, A. flavus, A. fumigatus and C. neoformans with MIC values of 64 μg/mL, 256 μg/mL, 128 μg/mL and 64 μg/mL, respectively[1].
Chitin synthase inhibitor 10 is related to the disruption of cell wall architecture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS. Nr. 2725075-01-2
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Molecular Weight 609.26
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Formel C24H23Br2N3O6
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SMILES
O=C(NC1=C(Br)C=C(OC)C=C1Br)/C=C/C(N2CCC3(CC2)C4=CC(OC)=CC=C4NC(O3)=O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Protokoll
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Chitin synthase inhibitor 10 Related Classifications
HY-151420 Related Classifications
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