Search Result

Results for "

Trypanosoma brucei hexokinase 1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Glucokinase (3) Hexokinase (26) 5-HT Receptor (1) Adenosine Kinase (1) AMPK (2) Angiotensin Receptor (1) Angiotensin-converting Enzyme (ACE) (2) Antibiotic (6) Apolipoprotein (1) Apoptosis (19) Aurora Kinase (1) Autophagy (8) Bacterial (14) Bcl-2 Family (1) Biochemical Assay Reagents (3) Casein Kinase (1) Cathepsin (3) CDK (2) Cholinesterase (ChE) (2) Clathrin (1) COX (2) Cytochrome P450 (5) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (8) Drug Derivative (4) Drug Intermediate (2) Drug Metabolite (1) EGFR (1) Endogenous Metabolite (8) Environmental Pollutants (2) Farnesyl Transferase (3) Fluorescent Dye (1) Fungal (8) Glucose-6-Phosphate Isomerase (GPI) (2) GLUT (1) Glycosidase (2) GSK-3 (3) HBV (1) HIV (1) HSV (6) IFNAR (1) IMPDH (1) Influenza Virus (2) Interleukin Related (3) Isotope-Labeled Compounds (8) Lactate Dehydrogenase (3) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (5) Mitophagy (1) Mitosis (1) mRNA (1) mTOR (2) Necroptosis (2) NF-κB (1) NTPDase (1) p38 MAPK (1) PAK (1) Paraptosis (3) Parasite (173) Phosphodiesterase (PDE) (3) Phospholipase (2) PKA (1) PROTACs (1) Proteasome (3) Reactive Oxygen Species (ROS) (7) Reference Standards (11) Ser/Thr Protease (2) STAT (4) Syk (1) TNF Receptor (2) Topoisomerase (2) VDAC (1) Wnt (1)
By Research Areas:	Cancer (48) Cardiovascular Disease (5) Infection (189) Inflammation/Immunology (21) Metabolic Disease (18) Neurological Disease (8)
Click Chemistry:	Azide (1)

239

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

2-Deoxy-D-glucose Maximum Cited Publications 347 Publications Verification 2-DG; 2-Deoxy-D-arabino-hexose; D-Arabino-2-deoxyhexose	Hexokinase HSV Apoptosis	Cancer
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

3-Bromopyruvic acid 30+ Cited Publications Bromopyruvic acid; 3-BrPA; hexokinase II Inhibitor II, 3-BP	Hexokinase Apoptosis Autophagy	Cancer
3-Bromopyruvate (Bromopyruvic acid) is an analogue of pyruvate and a potent hexokinase (HK)-II inhibitor with high tumor selectivity. 3-Bromopyruvate inhibits cell growth and induces apoptosis through interfering with glycolysis. 3-Bromopyruvate induces autophagy by stimulating ROS formation in breast cancer cells. Antimicrobial activities ^[1] .

Glycodeoxycholic acid 5 Publications Verification	Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis ^[1] .

Hesperadin 10+ Cited Publications	Aurora Kinase Autophagy Influenza Virus Parasite	Cancer
Hesperadin is an ATP competitive indolinone inhibitor of Aurora A and B. Hesperadin inhibits Aurora B with an IC₅₀ of 250 nM. Hesperadin inhibits the growth of Trypanosoma brucei by blocking nuclear division and cytokinesis. Hesperadin also is a broad-spectrum influenza antiviral ^[1] .

DDD85646 1 Publications Verification IMP-366	DNA/RNA Synthesis Parasite	Infection
DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC₅₀=2 nM; hNMT IC₅₀=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis ^[1] .

Benitrobenrazide 2 Publications Verification BNBZ; hexokinase 2 inhibitor 1	Hexokinase Apoptosis	Cancer
Benitrobenrazide (BNBZ) is the orally active inhibitor for hexokinase 2 with an IC₅₀ of 0.53 µM. Benitrobenrazide causes DNA damage, and exhibits antitumor effect ^[1] .

PROTAC HK2 Degrader-1 2 Publications Verification	PROTACs Hexokinase	Cancer
PROTAC HK2 Degrader-1 is a PROTAC consisting of Lonidamine (HY-B0486) as a target protein Hexokinase 2 (HK2) inhibitor and Thalidomide (HY-14658) as a CRBN ligand-linked PROTAC. PROTAC HK2 Degrader-1 selectively inhibits the proliferation of breast cancer cells by forming a ternary complex through the ubiquitin-proteasome system to degrade Hexokinase 2 (HK2) protein leading to mitochondrial damage and cell death. PROTAC HK2 Degrader-1 effectively inhibits breast tumor growth and reduces the colonic side effects of cisplatin for breast cancer research ^[1].

Ebsulfur	Parasite	Infection
Ebsulfur is a benzisothiazolone cytocidal inhibitor targeting the trypanothione reductase (TryR) of Trypanosoma brucei, with IC₅₀ values of 61-293 nM for Trypanosoma brucei. Ebsulfur can be used for the research of African trypanosomiasis ^[1].

Hexokinase, Yeast	Endogenous Metabolite	Others
Hexokinase, Yeast catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Yeast participates is also related to energy production, protection of mitochondrial integrity, and cell survival ^[1].

Hexokinase, microorganism	Endogenous Metabolite	Metabolic Disease
Hexokinase (ScHEX1) (EC 2.7.1.1) is a glycolytic enzyme hexokinase that is inhibited by n-acetylglucosamine. Inhibition of Hexokinase (ScHEX1) by n-acetylglucosamine leads to its separation from the mitochondrial outer membrane, resulting in activation of NLRP3 inflammasome ^[1].

NMT-IN-1	Parasite	Infection
NMT-IN-1 is a Trypanosoma brucei N-myristoyltransferase (TbNMT) inhibitor, with an IC₅₀ of 31 μM against TbNMT and an IC₅₀ of 66 μM against hNMT. As a thiazolidinone hit compound identified via virtual screening, NMT-IN-1 exerts enzymatic inhibitory effects by binding to the active site of TbNMT. NMT-IN-1 adopts a binding mode distinct from that of pyrazole sulfonamide inhibitors and can inhibit the myristoyl transfer reaction catalyzed by TbNMT. NMT-IN-1 is mainly used in the research of anti-parasitic lead compounds for human African trypanosomiasis (African sleeping sickness). It provides a structural basis for the subsequent optimization of TbNMT inhibitors with high activity, high selectivity and blood-brain barrier permeability ^[1].

2-Deoxy-D-glucose 6-phosphate disodium 2 Publications Verification	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive, 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the production and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research ^[1] .

Obtusifoliol 1 Publications Verification	Cytochrome P450 Parasite	Infection Cancer
Obtusifoliol is a specific CYP51 inhibitor, Obtusifoliol shows the affinity with K_d values of 1.2 μM and 1.4 μM for Trypanosoma brucei (TB) and human CYP51, respectively ^[1].

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth ^[1].

NPD-001	Phosphodiesterase (PDE) Parasite	Infection
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 (TbrPDEB1/2) inhibitor, with IC₅₀ values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection ^[1].

OBAA	Phospholipase Apoptosis	Inflammation/Immunology
OBAA is a potent phospholipase A2 (PLA2) inhibitor with an IC₅₀ of 70 nM. OBAA blocks Melittin-induced Ca ²⁺ influx in Trypanosoma brucei with an IC₅₀ of 0.4 μM ^[1] .

DNDI-6174	Parasite	Infection
DNDI-6174 is an orally active Leishmania cytochrome b (Qi site of cytochrome bc1 complex/complex III) inhibitor. DNDI-6174 binds to the Qi site of Leishmania cytochrome b, inhibits cytochrome bc1 complex activity in the parasite's electron transport chain across promastigote and axenic amastigote stages. DNDI-6174 reduces parasite burden in rodent models, inhibits growth of various Leishmania species, drug-resistant clinical isolates, and Trypanosoma cruzi, with marginal activity against Trypanosoma brucei. DNDI-6174 can be used for the research of visceral leishmaniasis, cutaneous leishmaniasis ^[1].

ML251	Parasite	Infection
ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC₅₀=0.37 μM) and T. cruzi PFK (IC₅₀=0.13 μM). ML251 can be used for the research of parasite ^[1].

SID 24785302	Hexokinase Parasite	Infection
SID 24785302 is a *hexokinase* inhibitor with antiparasitic activity. SID 24785302 exhibits activity against T. brucei and Leishmania. SID 24785302 can be used for the research of mitochondrial DNA disorders and parasitic infection ^[1] .

Glycodeoxycholic Acid (Standard)	Reference Standards Endogenous Metabolite STAT Autophagy	Inflammation/Immunology Cancer
Glycodeoxycholic Acid (Standard) is the analytical standard of Glycodeoxycholic Acid. This product is intended for research and analytical applications. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis ^[1] .

SDZ285428	Cytochrome P450 Fungal Parasite	Infection
SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h) ^[1].

JC-229	Parasite	Infection
JC-229 is a TbRPA1 inhibitor. JC-229 targets RPA1 in Trypanosoma brucei. JC-229 can be used for the research of Human African Trypanosomiasis (HAT) ^[1].

Ascofuranone	Parasite Antibiotic	Infection Cancer
Ascofuranone is an orally active inhibitor of Trypanosoma brucei brucei (TAO) with a K_i value of 2.38 nM. Ascofuranone inhibits IGF-1-induced cancer cell migration, invasion, motility and actin cytoskeleton formation, and exerts anti-tumor effects. Ascofuranone can be used in research related to tumor metastasis, African trypanosomiasis, bacterial infections, lung cancer and hepatocellular carcinoma ^[1] .

Dibenzosuberol	Parasite Drug Intermediate	Infection
Dibenzosuberol (Compound 2) is a key intermediate in the synthesis of compounds associated with inhibiting Trypanosoma thiol reductase (TryR). Dibenzosuberol also shows inhibition of T. brucei with an EC₅₀ value of 51.3 μM. Dibenzosuberol is also an impurity of Amitriptyline (HY-B0527) ^[1].

LY-266500	Mitochondrial Metabolism Parasite	Infection
LY-266500 is a succinyl CoA synthetase (SCS) specific inhibitor. LY-266500 has inhibitory effects on various parasites, such as Trypanosoma brucei brucei (IC₅₀ =0.6 μM) and Leishmania donovani (IC₅₀ =2.86 μM). LY-266500 can be used for research on parasitic infections ^[1].

Antiparasitic agent-30	Parasite Adenosine Kinase	Infection
Antiparasitic agent-30 is a potent adenosine kinase TbrAK modulator and antitrypanosomal agent. Antiparasitic agent-30 exhibits significant inhibitory activity against Trypanosoma brucei rhodesiense, while enhancing the activity of recombinant TbrAK(EC₅₀=38 nM, K_a=75 nM-497 nM). Antiparasitic agent-30 exerts its pharmacological effects by eliminating intrinsic substrate inhibition and hyperactivating TbrAK in Trypanosoma brucei rhodesiense. Antiparasitic agent-30 serves as a valuable tool molecule for studying acute African human trypanosomiasis (sleeping sickness) ^[1].

Hexokinase, Bacillus sp.	Endogenous Metabolite	Others
Hexokinase, Bacillus sp. catalyzes the phosphorylation of glucose, and is involved in glycolysis. Hexokinase, Bacillus sp. participates is also related to energy production, protection of mitochondrial integrity, and cell survival ^[1].

2-Deoxy-D-glucose 6-phosphate	Hexokinase Glucose-6-Phosphate Isomerase (GPI)	Cancer
2-Deoxy-D-glucose 6-phosphate disodium is an ATP-competitive and 2-deoxy-D-glucose non-competitive *Hexokinase* inhibitor, with a K_i value of 1.45 mM against bovine heart hexokinase. 2-Deoxy-D-glucose 6-phosphate disodium exerts ATP-competitive and 2-deoxy-D-glucose non-competitive inhibitory effects on bovine heart hexokinase. 2-DG inhibits glycolysis via the generation and intracellular accumulation of 2-Deoxy-D-glucose 6-phosphate disodium, thereby inhibiting the functions of hexokinase and Glucose-6-phosphate isomerase, and inducing cell death. 2-Deoxy-D-glucose 6-phosphate disodium can be used in cancer-related research ^[1] .

5,7,8-Trimethoxycoumarin	Parasite	Infection
5,7,8-Trimethoxycoumarin is an anti-parasite agent with IC₅₀s of 25.5 μM and 57.7 μM against Trypanosoma cruzi and L. amazonensis, respectively ^[1].

CAA-0225	Cathepsin	Others
CAA-0225 is a tissue protease L inhibitor that inhibits rat liver tissue protease L with a IC₅₀ value of 1.9 nM. CAA-0225 can participate in the degradation of autophagosome membrane markers LC3-II and GABARAP (HY-P72639), improve cardiac function in mice with reperfusion injury, and kill and eliminate Trypanosoma brucei parasites ^[1][2][3].

Antitrypanosomal agent 2	Parasite	Infection
Antitrypanosomal agent 2 is a potent and selective *trypanosoma* *brucei* inhibitor ^[1].

Isometamidium chloride	Parasite	Infection
Isometamidium chloride is an antiprotozoal agent, that exhibits activity against trypanosome. Isometamidium chloride can be used in research of african sleeping sickness ^[1].

*Anti-Trypanosoma* cruzi agent-3**	Parasite	Infection
Anti-Trypanosoma cruzi agent-3 (Compound 7c) is an antiprotozoal agent ^[1].

Ro 19-9638	Parasite	Infection
Ro 19-9638 is the major metabolite of Ro 15-0216. Ro 19-9638 exhibits antiparasitic efficacy against Trypanosoma brucei rhodesiense with an IC₅₀ of 0.0341 µg/mL ^[1].

Antitrypanosomal agent 21	Paraptosis	Infection
Antitrypanosomal agent 21 (Compound C-1) is a **trypanosoma brucei** inhibitor. Antitrypanosomal agent 21 decreases the level of D6XM23 in parasite lysates ^[1].

Antitrypanosomal agent 8	Parasite	Infection
Antitrypanosomal agent 8 (compound 3b) has potent antitrypanosomal activity against **Trypanosoma brucei with an IC₅₀** value of 0.79 μM and exhibits certain cytotoxicity in L6 cells (IC₅₀=80.95 μM) ^[1].

TbPTR1 inhibitor 1	Parasite	Infection
TbPTR1 inhibitor 1 (compound 5d) is a potent kinetoplastid pteridine reductase 1 (PTR1) inhibitor with an *IC₅₀*<0.1 nM for TbPTR1. TbPTR1 inhibitor 1 has inhibitory activity against Trypanosoma brucei (EC₅₀=0.66 μM) ^[1].

Panowamycin A	Parasite	Infection
Panowamycin A is an isochroman compound that can be produced by Streptomyces sp. K07-0010. Panowamycin A exhibits antitrypanosomal activity against the Trypanosoma brucei brucei GUTat 3.1 strain (IC₅₀: 0.40 μg/mL). Panowamycin A shows weak cytotoxicity towards human fetal lung fibroblast MRC-5 cells (IC₅₀: 2.95 μg/mL). Panowamycin A can be used for research in the field of antitrypanosomal studies ^[1].

Proteasome-IN-6	Proteasome Parasite	Infection
Proteasome-IN-6 (Compound J-80) inhibits the β5 catalytic subunit of the Trypanosoma brucei 20S proteasome, inibits T. b. brucei, T. b. gambiense and T. b. rhodesiense with EC₅₀s of 157 nM, 220 nM and 156 nM, respectively. Proteasome-IN-6 exhibits antitrypanosomal activity in mouse model ^[1].

DHFR-IN-19	Dihydrofolate reductase (DHFR)	Infection
DHFR-IN-19 (Compound 2g) is a selective inhibitor for TbDHFR with K_i of 9 nM. DHFR-IN-19 exhibits antiparasitic activity against Trypanosoma brucei with an EC₅₀ of 14.5 μM ^[1].

*Anti-Trypanosoma* cruzi agent-6**	Parasite	Infection
Anti-Trypanosoma cruzi agent-6 (Compound 8) exhibits inhibitory activity against Trypanosoma cruzi, that inhibits the epimastigote, trypomastigote and amastigote form of T. cruzi with IC₅₀s of 24.7 µM, 1.8 µM and 1.6 µM, respectively ^[1].

PEX5-PEX14 PPI-IN-3	Parasite	Infection
PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC₅₀ of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC₅₀ of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity ^[1].

Cat. No.	Product Name

HY-L058

Glycolysis Compound Library

1,296 compounds

Glycolysis is a series of metabolic processes by which one molecule of glucose is catabolized to two molecules of pyruvate with a net gain of two ATP. Glycolysis takes place in 10 steps and catalyzed by a series of enzyme, such as hexokinase, Glucose-6-phosphate isomerase, Phosphofructokinase, etc. Glycolysis is used by all cells in the body for energy generation.

Most cancer cells exhibit increased glycolysis and use this metabolic pathway for generation of ATP as a main source of their energy supply. This phenomenon is known as the Warburg effect and is considered as one of the most fundamental metabolic alterations during malignant transformation. Because increased aerobic glycolysis is commonly seen in a wide spectrum of human cancers, development of novel glycolytic inhibitors as a new class of anticancer agents is likely to have broad therapeutic applications.

MCE provides a unique collection of 1,296 glycolysis compounds that mainly target hexokinase, glucokinase, enolase, pyruvate kinase, PDHK, etc. MCE Glycolysis Compound Library is a useful tool for glucose metabolism research and anti-cancer drug discovery.

HY-L092

Glucose Metabolism Compound Library

1,699 compounds

Glucose homeostasis is tightly regulated to meet the energy requirements of the vital organs and maintain an individual’s health. Glucose metabolism includes glycolysis, tricarboxylic acid cycle, pentose phosphate pathway, oxidative phosphorylation and other metabolic pathways. Glucose is the major carbon source that provides the main energy for life. Glucose metabolism dysregulation is also implicated in many diseases such as diabetes, heart disease, neurodegenerative diseases and even cancer.

MCE offers a unique collection of 1,699 compounds related to glucose metabolism, which target glucose metabolism related targets, such as GLUT, Hexokinase, Pyruvate Kinase, IDH, etc. MCE glucose metabolism library is a powerful tool for studying glucose metabolism and drug discovery of diseases related to glucose metabolism.

HY-L009

Kinase Inhibitor Library

3,886 compounds

Kinase is an enzyme that adds phosphate groups to other molecules. This process is known as phosphorylation. Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and so on. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinases are a large group of drug targets in drug discovery. Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders.

Kinase inhibitor library designed by MCE contains 3,886 kinase inhibitors and regulators mainly targeting protein kinases (VEGFR, EGFR, BTK, CDK, Akt, etc.), lipid kinases (PI3K, PI4K, SK, etc.) and carbohydrate kinases (Hexokinase), and is a useful tool for kinase drug discovery and related research.

Cat. No.	Product Name	Type

HY-P1759A

N-CBZ-Phe-Arg-AMC hydrochloride Z-FR-AMC hydrochloride	Biochemical Assay Reagents
N-CBZ-Phe-Arg-AMC (Z-FR-AMC) hydrochloride is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes ^[1] .

Cat. No.	Product Name	Target	Research Area

HY-P10108

Hexokinase II VDAC binding domain peptide, cell-permeable Hxk2VBD peptide, cell-permeable	Hexokinase	Neurological Disease
Hexokinase II VDAC binding domain peptide (Hxk2VBD peptide) is a cell-permeable hexokinase II VDAC binding domain. Hexokinase II VDAC binding domain peptide inhibits mitochondrial localization of hexokinase 2 (HXK2). Hexokinase II VDAC binding domain peptide inhibits neurotrophic factor-directed axon outgrowth ^[1].

HY-P11102

Temporin-SHa	Bacterial Fungal HIV Parasite	Infection Cancer
Temporin-Sha is an antibacterial peptide with extensive biological activity. Temporin-Sha exhibits broad-spectrum antibacterial activity (e.g., against L. ivanovii, MIC = 6.25 μM), and is effective against Gram-negative bacteria (such as Escherichia coli, MIC = 10 μM), including drug-resistant strains (such as Methicillin (HY-121544)-resistant Staphylococcus aureus). Temporin-Sha also has inhibitory effects on Candida albicans (MIC = 25 μM), Saccharomyces cerevisiae (MIC = 12 μM), the pre-flagellated and non-flagellated forms of Leishmania infantum (IC₅₀ = 5-20 μM), and Trypanosoma cruzi (IC₅₀ = 17 μM). Temporin-Sha exhibits antiviral activity against HSV-1 and has anti-cancer effects (cytotoxicity against breast cancer cells MCF-7 and lung cancer cells H460, etc.) ^[1] .

HY-P10795

NK-2 Antibiotic NK 2	Parasite Bacterial Fungal	Infection
NK-2 (Antibiotic NK 2), a shortened linear amphipathic NK-Lysin analog (comprising residues 39 to 65 of NK-lysin), is an antimicrobial peptide that exhibits potent activities against trypanosoma cruzi, Candida albicans, gram-positive and gram-negative bacteria. NK-2 can kill trypanosomes residing inside the human glioblastoma cell line 86HG39, left the host cells apparently unharmed ^[1].

HY-P11367

Boc-Ala-Gly-Pro-Arg-AMC	Fluorescent Dye Ser/Thr Protease	Infection Metabolic Disease
Boc-Ala-Gly-Pro-Arg-AMC is a synthetic fluorescent substrate, widely used for the detection of protease activity. Boc-Ala-Gly-Pro-Arg-AMC can be used to detect the activity of serine proteases and the oligopeptide enzyme B of Trypanosoma brucei ^[1] .

Species:	Human (7) Mouse (1)
Tag:	His (7) Tag Free (1) GST (1)
Source:	Sf9 insect cells (4) P. pastoris (2) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700580

	*HK1/Hexokinase-1* Protein, Human (His)** hexokinase-1; HK1; Brain form hexokinase; hexokinase type I; HK I; hexokinase-A	Human	E. coli
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P700581

	*HK1/Hexokinase-1* Protein, Human (P. pastoris, His)** hexokinase-1; HK1; Brain form hexokinase; hexokinase type I; HK I; hexokinase-A	Human	P. pastoris
	The HK1/hexokinase-1 protein phosphorylates hexose sugars, including D-glucose, D-glucosamine, D-fructose, D-mannose, and 2-deoxy-D-glucose, to form the corresponding hexose 6-phosphate. HK1/Hexokinase-1 Protein, Human (P. pastoris, His) is the recombinant human-derived HK1/Hexokinase-1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P703943

	HK2 Protein, Human (sf9, His) hexokinase-2; hexokinase type II; hexokinase-B; Muscle form hexokinase	Human	Sf9 insect cells
	HK2 Protein, Human (sf9, His) is the recombinant human-derived HK2 protein, expressed by Sf9 insect cells, with C-10*His tag.

HY-P703943Y

	HK2 Protein, Human (sf9, His, solution) hexokinase-2; hexokinase type II; hexokinase-B; Muscle form hexokinase	Human	Sf9 insect cells
	HK2 Protein, Human (sf9, His, solution) is the recombinant human-derived HK2 protein, expressed by Sf9 insect cells, with C-10*His tag.

HY-P74881

	*HK3/Hexokinase-3 Protein, Human (sf9, His-GST)* hexokinase-3; HK III; hexokinase-C; HK3	Human	Sf9 insect cells
	The HK3 (hexokinase-3) protein promotes the phosphorylation of hexoses (i.e., D-glucose and D-fructose) to form hexose-6-phosphate (specifically, D-glucose 6-phosphate and 6-phosphate), Plays a vital role in cell metabolism. D-fructose 6-phosphate. HK3/Hexokinase-3 Protein, Human (sf9, His-GST) is the recombinant human-derived HK3/Hexokinase-3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag.

HY-P75790

	Glucokinase/GCK Protein, Human hexokinase-4; HK4; hexokinase-D; Glucokinase	Human	E. coli
	Glucokinase/GCK proteins catalyze hexose phosphorylation, converting D-glucose, D-fructose, and D-mannose into their respective hexose 6-phosphates. Glucokinase/GCK Protein, Human is the recombinant human-derived Glucokinase/GCK protein, expressed by E. coli , with tag free.

HY-P704013

	HK2 Protein, Mouse (sf9, His) hexokinase-2; hexokinase type II; Hk2 ;	Mouse	Sf9 insect cells
	HK2 Protein, Mouse (sf9, His) is the recombinant mouse-derived HK2 protein, expressed by Sf9 insect cells, with C-His tag.

HY-P71822

	GCKR Protein, Human (P.pastoris, His) FGQTL5; GCK ; GLRE; Glucokinase regulatory protein; hexokinase 4 regulator; hexokinase-D; HK IV; HK4	Human	P. pastoris
	The GCKR protein plays a critical regulatory role in glucokinase (GCK) by forming an inactive complex and recruiting GCK to the nucleus after meals. Its interaction with GCK is finely tuned by fructose metabolites; binding of GCKR to fructose-6-phosphate increases the affinity for GCK, whereas binding to fructose-1-phosphate decreases the affinity, thereby releasing inhibition. GCKR Protein, Human (P.pastoris, His) is the recombinant human-derived GCKR protein, expressed by P. pastoris , with N-His labeled tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-13966S

2-Deoxy-D-glucose-d1 1 Publications Verification
2-Deoxy-D-glucose-d is the deuterium labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S2

2-Deoxy-D-glucose-13C
2-Deoxy-D-glucose- ¹³C is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S4

2-Deoxy-D-glucose-13C-1
2-Deoxy-D-glucose- ¹³C-1 is the ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase .

HY-13966S3

2-Deoxy-D-glucose-13C6
2-Deoxy-D-glucose- ¹³C₆ (2-DG- ¹³C₆) is ¹³C labeled 2-Deoxy-D-glucose. 2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on *hexokinase* .

HY-W653999

Glycodeoxycholic acid-d5
Glycodeoxycholic acid-d₅ is deuterium labeled Glycodeoxycholic Acid. Glycodeoxycholic Acid is a natural product found in Streptomyces nigricans, Trypanosoma brucei and C. elegans. Glycodeoxycholic Acid induces hepatocyte necrosis and autophagy in patients with obstructive cholestasis ^[1] .

HY-W040073S

Nifurtimox-d4
Nifurtimox-d₄ is deuterium labeled Nifurtimox. Nifurtimox, an antiprotozoal agent, which is generally used for the treatment of infections with Trypanosoma cruzi, has been used in the therapy of neuroblastoma. Nifurtimox affects enzyme activity of lactate dehydrogenase (LDH).

HY-W767186

D-Mannoheptulose-13C7

D-Mannoheptulose- ¹³C₇ is the ¹³C-labeled D-Mannoheptulose. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources ^[1] .

HY-U00462S

D-Mannoheptulose-13C

D-Mannoheptulose- ¹³C is the ¹³C labeled D-Mannoheptulose (HY-U00462) ^[1]. D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources .

Host:	Mouse (9) Rabbit (6)
Reactivity:	Human (15) Rat (11) Mouse (9) Rabbit (2) Hamster (2)
Application:	IHC-P (8) ICC/IF (4) IP (5) WB (15) FC (5) ELISA (7)
Isotype:	IgG (5) IgG1 (6) IgG,IgG/Kappa (1)
Conjugation:	Non-conjugated (15)
Clonality:	Monoclonal (10) Recombinant (3)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P80702

	Hexokinase I Antibody (YA739) HK1; hexokinase-1; Brain form hexokinase; hexokinase type I; HK I	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA739) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P85209

	Hexokinase I Antibody (YA4901) HK1; hexokinase-1; Brain form hexokinase; hexokinase type I; HK I	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA4901) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hexokinase I.

HY-P80702A

	Hexokinase I Antibody (YA739)(PBS only) HK1; hexokinase-1; Brain form hexokinase; hexokinase type I; HK I	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA739) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P85528

	Hexokinase I Antibody (YA5220) BB404130; Brain form hexokinase; dea; Glycolytic enzyme; HEXOKIN; hexokinase PI; hexokinase type I; hexokinase, tumor isozyme; hexokinase-1; hexokinase-A; HK I; HK1; HK1 tb; Hk1-s; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; HXK1_HUMAN; mHk1-s.	WB	Human, Mouse, Rat
	Hexokinase I Antibody (YA5220) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Hexokinase I.

HY-P86604

	Hexokinase II Antibody (YA6296) HK2; hexokinase-2; hexokinase type II; HK II; Muscle form hexokinase	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Hexokinase II Antibody (YA6296) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P82295

	Glucokinase Antibody (YA2040) GCK; Glucokinase; hexokinase type IV; HK IV; hexokinase-4; HK4; hexokinase-D	WB	Human
	Glucokinase Antibody (YA2040) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Glucokinase.

HY-P85184

	Glucokinase Antibody (YA4876) GCK; Glucokinase; hexokinase type IV; HK IV; hexokinase-4; HK4; hexokinase-D	WB, ELISA	Human
	Glucokinase Antibody (YA4876) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Glucokinase.

HY-P80703

	Hexokinase II Antibody (YA386) HKII; HXK2	WB, IHC-P, IP	Human, Rat, Hamster
	Hexokinase II Antibody (YA386) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P80703A

	Hexokinase II Antibody (YA386)(PBS only) HKII; HXK2	WB, IHC-P, IP	Human, Rat, Hamster
	Hexokinase II Antibody (YA386) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Hexokinase II.

HY-P83243

	HKDC1 Antibody (YA2988) hexokinase domain-containing protein 1	WB, IP	Human
	HKDC1 Antibody (YA2988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HKDC1.

HY-P84385

	Hexokinase II Antibody (YA4082) HKII; HXK2; DKFZp686M1669; HK2	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
	Hexokinase II Antibody (YA4082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase II.

HY-P83243A

	HKDC1 Antibody (YA2988)(PBS only) hexokinase domain-containing protein 1	WB, IP	Human
	HKDC1 Antibody (YA2988) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HKDC1.

HY-P84385A

	Hexokinase II Antibody (YA4082)(PBS only) HKII; HXK2; DKFZp686M1669; HK2	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit
	Hexokinase II Antibody (YA4082) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase II.

HY-P84156

	Hexokinase I Antibody (YA3853) HKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA3853) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.

HY-P84156A

	Hexokinase I Antibody (YA3853)(PBS only) HKI; HXK1; HK1-ta; HK1-tb; HK1-tc; HK1	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Rat
	Hexokinase I Antibody (YA3853) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Hexokinase I.