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Cat. No.: HY-158323

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HGPRT/TBrHGPRT1-IN-1

Name: HGPRT/TBrHGPRT1-IN-1
Brand: MedChemExpress
SKU: HY-158323
Availability: PreOrder

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both K_i=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer.

For research use only. We do not sell to patients.

CAS No.: 3081803-13-3
Formula: C₁₅H₂₄N₆O₉P₂
Molecular Weight:494.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

HGPRT/TBrHGPRT1-IN-1 Chemical Structure

CAS No.: 3081803-13-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (1)
Purity & Documentation
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Biological Activity

Description

All Parasite Isoforms :

In Vitro

HGPRT/TBrHGPRT1-IN-1 inhibition activity is K_i=3 nM (human HGPRT); 10 nM (Pf HGXPRT); 60 nM (Pv HGPRT); 3 nM (TBr HGPRT1); 0.3 μM (Mtb HGPRT); 0.1 μM (Hp XGHPR); 4 μM (Ec XGPRT)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3081803-13-3
Molecular Weight 494.33
Formula C₁₅H₂₄N₆O₉P₂
SMILES

NC1=NC2=C(C(N1)=O)N=CN2[C@@H]3C[C@H](N(C3)C(CCP(O)(O)=O)=O)COCCP(O)(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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SAR QSAR Environ Res

Identification of potential inhibitors of hypoxanthine-guanine phosphoribosyl transferase for cancer treatment by molecular docking, dynamics simulation and in vitro studies. [Abstract]

2025 Mar;36(3):169-188. PMID: 40126362

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Cheshmazar N, et al. Key structural requirements of benzamide derivatives for histone deacetylase inhibition: design, synthesis and biological evaluation. Future Med Chem. 2024 Apr 16. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

HGPRT/TBrHGPRT1-IN-1

1 Cited Publications

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Biological Activity
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Chemical Information
Publications (1)
Purity & Documentation
References

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HGPRT/TBrHGPRT1-IN-1

Publications Citing Use of MedChemExpress (MCE) HGPRT/TBrHGPRT1-IN-1

All Parasite Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

HGPRT/TBrHGPRT1-IN-1 Related Classifications

HY-158323 Related Classifications

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