PEX5-PEX14 PPI-IN-1
PEX5-PEX14 PPI-IN-1 (Compound 8) is a PEX14-PEX5 PPI inhibitor. PEX5-PEX14 PPI-IN-1 disrupts the PEX5-TbPEX14 PPI with a Ki of 53 μM. PEX5-PEX14 PPI-IN-1 inhibits the bloodstream form of T. b. brucei (EC50: 5 μM).
For research use only. We do not sell to patients.
- CAS No.: 3052256-26-2
- Formula: C26H28N4O3
- Molecular Weight:444.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
21 μM
Compound: 8
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 66 hrs by resazurin staining based analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 66 hrs by resazurin staining based analysis
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[PMID: 37406382] |
Chemical Information
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CAS No. 3052256-26-2
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Molecular Weight 444.53
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Formula C26H28N4O3
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SMILES
O=C(OC)[C@@H](N1C([C@H](CC2=CNC3=C2C=CC=C3)NCCC1)=O)CC4=CNC5=C4C=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)