Phosphoglycerate kinase, yeast
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Phosphoglycerate kinase (PGK), yeast is a monomeric glycolytic/gluconeogenic enzyme that can be found in Saccharomyces cerevisiae. Phosphoglycerate kinase, yeast catalyzes phosphoryl-group transfer from 1,3-bisphosphoglycerate to ADP to form 3-phosphoglycerate and ATP, binds 3PGA, ATP, and Mg2+, and adopts a closed conformation. Phosphoglycerate kinase, yeast is commonly used in biochemical research.
For research use only. We do not sell to patients.
- CAS No.: 9001-83-6
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Microbial Metabolite |
Phosphoglycerate kinase, yeast is a monomeric enzyme that forms a closed conformation complex with 3PGA, ATP, and Mg2+[1].
Phosphoglycerate kinase, yeast can utilize GTP and ITP as substrates[1].
Phosphoglycerate kinase, yeast does not adopt a closed catalytic conformation when complexed with 3-PGA and MgAMP-PNP[2].
Phosphoglycerate kinase, yeast (5 μg/mL; 30 min) shows negligible plasmin reductase activity in an ELISA assay using purified plasmin as substrate[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
2.7.2.3
≥1000 U/mg protein
One unit will convert 1.0 μmole of 1,3-diphosphoglycerate to 3-phosphoglycerate per min at pH 6.9 at 25 °C.
Chemical Information
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CAS No. 9001-83-6
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Appearance Viscous Liquid
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Color Colorless to light yellow
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SMILES
[Phosphoglycerate kinase, yeast]
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Synonyms
PGK
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (266 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Rojas-Pirela M, et al. Phosphoglycerate kinase: structural aspects and functions, with special emphasis on the enzyme from Kinetoplastea. Open Biol. 2020 Nov;10(11):200302. [Content Brief]
[2]. Bernstein BE, Michels PA, Hol WG. Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature. 1997 Jan 16;385(6613):275-8. [Content Brief]
[3]. Lay AJ, Jiang XM, Kisker O, et al.. Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase. Nature. 2000 Dec 14;408(6814):869-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Phosphoglycerate kinase, yeast Related Classifications
HY-P2822 Related Classifications
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