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  3. ML251

ML251 

Cat. No.: HY-12607 Purity: 98.69%
Handling Instructions

ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite.

For research use only. We do not sell to patients.

ML251 Chemical Structure

ML251 Chemical Structure

CAS No. : 1486482-16-9

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1450 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

ML251, a potent nanomolar T. brucei and T. cruzi phosphofructokinase (PFK) inhibitor, inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite[1].

IC50 & Target

IC50: 0.37 μM (T. brucei PFK)[1].
IC50: 0.13 μM (T. cruzi PFK)[1]

In Vitro

ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: T. brucei
Concentration: 0~33.3 μg/mL
Incubation Time:
Result: Dose-dependent reduction of cell viability.
Molecular Weight

426.27

Formula

C₁₇H₁₃Cl₂N₃O₄S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (586.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3459 mL 11.7297 mL 23.4593 mL
5 mM 0.4692 mL 2.3459 mL 4.6919 mL
10 mM 0.2346 mL 1.1730 mL 2.3459 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (4.88 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.88 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
ML251
Cat. No.:
HY-12607
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