2. Acetylastragaloside I

Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection.

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Acetylastragaloside I Chemical Structure

Acetylastragaloside I Chemical Structure

CAS No. : 84687-47-8

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Acetylastragaloside I Related Antibodies

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Description

Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].

IC50 & Target

IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)[1]
In Vitro

Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively[1].
Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acetylastragaloside I Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Rat skeletal myoblasts (L6) cell line
Concentration: 0.123-90 μg/mL
Incubation Time: 72 hours
Result: Showed cytotoxicity to L6 cells with an IC50 value of 24.2 μg/mL.
Molecular Weight

911.08

Formula

C47H74O17
CAS No.
SMILES

CC(O[C@@H]1CO[C@@H](OC2CC[C@]34CC35CC[C@]6(C)[C@@H]([C@@]7(C)CC[C@@H](C(C)(O)C)O7)[C@H](O)C[C@@]6(C)C5C[C@@H](O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)C4C2(C)C)[C@H](OC(C)=O)[C@H]1OC(C)=O)=O
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Purity & Documentation
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  • Do most proteins show cross-species activity?

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Keywords:

Acetylastragaloside I84687-47-8Inhibitorinhibitorinhibit

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