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Cat. No.: HY-129288

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GW837016X

Name: GW837016X
Brand: MedChemExpress
SKU: HY-129288
Availability: PreOrder

(Synonyms: NEU-391)

GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 833473-68-0
Formule: C₂₅H₂₀ClFN₄OS
Masse moléculaire:478.97

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GW837016X Chemical Structure

CAS No.: 833473-68-0

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis^[1].

IC₅₀ & Target

^[1]

ErbB2

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Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	205 nM Compound: 7	Antiproliferative activity against human BT474 cells overexpressing ErbB2 after 3 days by methylene blue staining Antiproliferative activity against human BT474 cells overexpressing ErbB2 after 3 days by methylene blue staining	[PMID: 18842405]
Fibroblast	IC₅₀	>1 μM Compound: 7	Antiproliferative activity against human foreskin fibroblast after 3 days by methylene blue staining Antiproliferative activity against human foreskin fibroblast after 3 days by methylene blue staining	[PMID: 18842405]
HN5	IC₅₀	536 nM Compound: 7	Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days by methylene blue staining Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days by methylene blue staining	[PMID: 18842405]

In Vitro

GW837016X inhibits proliferation of bloodstream Trypanosoma brucei with an IC₅₀ value of 0.4 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .

In Vivo

GW837016X (130 mg/kg; p.o.; daily for 10 days) inhibits Trypanosoma brucei proliferation and increases the mean survival in Trypanosoma brucei infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Swiss Webster mice (T. brucei (Lister427)) ^[1]
Dosage:

130 mg/kg
Administration:

P.o.; daily for 10 days
Result:

Increased the mean survival and inhibited Trypanosoma brucei proliferation.

Chemical Information

CAS No. 833473-68-0
Masse moléculaire 478.97
Formule C₂₅H₂₀ClFN₄OS
SMILES

FC1=CC(COC2=CC=C(NC3=C4C(C=C(C#C[C@H]5NCCC5)S4)=NC=N3)C=C2Cl)=CC=C1
Synonyms

NEU-391
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Woodring JL, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. ACS Med Chem Lett. 2018 Sep 4;9(10):996-1001. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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