country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-129288

Copy Link Print Information

GW837016X

(Synonyms: NEU-391)

GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis.

For research use only. We do not sell to patients.

CAS No.: 833473-68-0
Formula: C₂₅H₂₀ClFN₄OS
Molecular Weight:478.97

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GW837016X Chemical Structure

CAS No.: 833473-68-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

GW837016X (NEU-391) is an orally active ErbB-2 kinase covalent inhibitor. GW837016X also is a potent antitrypanosome agent. GW837016X inhibits mitosis and cytokinesis^[1].

IC₅₀ & Target^[1]

ErbB2

All EGFR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
BT-474	IC₅₀	205 nM Compound: 7	Antiproliferative activity against human BT474 cells overexpressing ErbB2 after 3 days by methylene blue staining Antiproliferative activity against human BT474 cells overexpressing ErbB2 after 3 days by methylene blue staining	[PMID: 18842405]
Fibroblast	IC₅₀	>1 μM Compound: 7	Antiproliferative activity against human foreskin fibroblast after 3 days by methylene blue staining Antiproliferative activity against human foreskin fibroblast after 3 days by methylene blue staining	[PMID: 18842405]
HN5	IC₅₀	536 nM Compound: 7	Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days by methylene blue staining Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days by methylene blue staining	[PMID: 18842405]

In Vitro

GW837016X inhibits proliferation of bloodstream Trypanosoma brucei with an IC₅₀ value of 0.4 µM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GW837016X (130 mg/kg; p.o.; daily for 10 days) inhibits Trypanosoma brucei proliferation and increases the mean survival in Trypanosoma brucei infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Swiss Webster mice (T. brucei (Lister427)) ^[1]
Dosage:

130 mg/kg
Administration:

P.o.; daily for 10 days
Result:

Increased the mean survival and inhibited Trypanosoma brucei proliferation.

Chemical Information

CAS No. 833473-68-0
Molecular Weight 478.97
Formula C₂₅H₂₀ClFN₄OS
SMILES

FC1=CC(COC2=CC=C(NC3=C4C(C=C(C#C[C@H]5NCCC5)S4)=NC=N3)C=C2Cl)=CC=C1
Synonyms

NEU-391
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Woodring JL, et al. Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation. ACS Med Chem Lett. 2018 Sep 4;9(10):996-1001. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

Get Quote In-stock