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  3. Antitrypanosomal agent 5

Antitrypanosomal agent 5 

Cat. No.: HY-146071
Handling Instructions

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively.

For research use only. We do not sell to patients.

Antitrypanosomal agent 5 Chemical Structure

Antitrypanosomal agent 5 Chemical Structure

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Description

Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively[1].

In Vitro

After dosing T. brucei cells with Antitrypanosomal agent 5 (Compound 25; 200-1000 nM) for 12 hours, Western blot analyses shows Antitrypanosomal agent 5 inhibits tubulin polymerization in T. brucei cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line: T. brucei cells[1]
Concentration: 200nM; 500 nM; 1000 nM
Incubation Time: 12 hours
Result: Polymerized tubulin in T. brucei cells was significantly decreased with the treatment of Antitrypanosomal agent 5 at 500 nM and 1000 nM.
Molecular Weight

570.66

Formula

C30H30N6O4S

SMILES

CN(S(=O)(CC1=CC=CC=C1)=O)C2=CC=C(C=C2OCC3=CC=C(C=C3)C(N)=N)NC(C4=CC=CC(C(N)=N)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Antitrypanosomal agent 5
Cat. No.:
HY-146071
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