Antitrypanosomal agent 5
Antitrypanosomal agent 5 (Compound 25)is a selective anti-trypanosomal agent with IC50s of 1 nM and 483.3 µM against T. brucei cell growth and HEK293 cells growth , respectively.
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- Fòrmula: C30H30N6O4S
- Peso molecular:570.66
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
483.3 μM
Compound: 25
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Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 35396128] |
| RAW264.7 | IC50 |
>500 μM
Compound: 25
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Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
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[PMID: 35396128] |
After dosing T. brucei cells with Antitrypanosomal agent 5 (Compound 25; 200-1000 nM) for 12 hours, Western blot analyses shows Antitrypanosomal agent 5 inhibits tubulin polymerization in T. brucei cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:T. brucei cells[1]
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Concentration:200nM; 500 nM; 1000 nM
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Incubation Time:12 hours
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Result:Polymerized tubulin in T. brucei cells was significantly decreased with the treatment of Antitrypanosomal agent 5 at 500 nM and 1000 nM.
Chemical Information
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Peso molecular 570.66
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Fòrmula C30H30N6O4S
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SMILES
CN(S(=O)(CC1=CC=CC=C1)=O)C2=CC=C(C=C2OCC3=CC=C(C=C3)C(N)=N)NC(C4=CC=CC(C(N)=N)=C4)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antitrypanosomal agent 5 Related Classifications
HY-146071 Related Classifications
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