NEU-5123 

NEU-5123 is a human kinase inhibitor with potent inhibitory activity to several kinases. NEU-5123 is a Trypanosome proliferation inhibitor. NEU-5123 can be used for the research of infection^[1].

NEU-5123 (Compound 18a) potently inhibits Trypanosoma brucei proliferation (PEC₅₀ = 7.7), exhibits low toxicity to human lung fibroblast MRC5 cells (PTC₅₀ = 4.8) with a SI of 850^[1].
NEU-5123 (5 μM) potently inhibits 14 human kinases (defined as >50% inhibition) in a panel of 45 human kinases^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NEU-5123 (Compound 18a) (10 mg/kg, i.p., daily for 5 days from day 3 to day 7 post-infection) does not achieve cure but extends the average survival time of mice by 8.8 days in female NMRI mice infected with Trypanosoma brucei STIB795^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

357.45

C₂₂H₂₃N₅

CN1C=C(C=N1)C2=C3C=C(NC3=NC=C2)C4=CC=C(C=C4)CN5CCCC5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bachovchin KA, et al. Optimization of Physicochemical Properties and ADME for 2,4-Substituted 1H-Pyrrolo[2,3b]pyridines Inhibitors of Trypanosome Proliferation. J Med Chem. 2025 Oct 9;68(19):20154-20179.  [Content Brief]