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  3. Biochemical Assay Reagents
  4. PEX5-PEX14 PPI-IN-2

PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC50 values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection.

For research use only. We do not sell to patients.

PEX5-PEX14 PPI-IN-2

PEX5-PEX14 PPI-IN-2 Chemical Structure

CAS No. : 3052256-03-5

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PEX5-PEX14 PPI-IN-2 Related Antibodies

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Description

PEX5-PEX14 PPI-IN-2 (compound 12) is a PEX14-PEX5 protein-protein interaction (PPI) inhibitor. PEX5-PEX14 PPI-IN-2 inhibits PEX14-PEX5 PPI with EC50 values of 5 and 17 µM in T. b. brucei and HepG2 cells, respectively. PEX5-PEX14 PPI-IN-2 can be used in the research of diseases related to trypanosome infection[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 EC50
17 μM
Compound: 12
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 66 hrs by resazurin staining based analysis
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 66 hrs by resazurin staining based analysis
[PMID: 37406382]
Molecular Weight

430.50

Formula

C25H26N4O3
CAS No.
SMILES

O=C(OC)[C@@H](N1C[C@H](CC2=CNC3=C2C=CC=C3)NC(C1)=O)CC4=CNC5=C4C=CC=C5
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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PEX5-PEX14 PPI-IN-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PEX5-PEX14 PPI-IN-23052256-03-5Biochemical Assay ReagentsT. b. bruceiHepG2trypanosomeInhibitorinhibitorinhibit

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