Search Result
Results for "
low-cytotoxicity
" in MedChemExpress (MCE) Product Catalog:
7
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-N2193
-
|
|
Flavivirus
Dengue Virus
Apoptosis
|
Infection
Cancer
|
|
Hirsutine, an indole alkaloid of Uncaria rhynchophylla, exhibits anti-cancer activity. Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity .
|
-
-
- HY-18620
-
DZ2002
1 Publications Verification
|
STAT
PI3K
NF-κB
MEK
ERK
Bacterial
Antibiotic
Akt
|
Inflammation/Immunology
|
|
DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis .
|
-
-
- HY-17605A
-
|
GS-9883 sodium
|
HIV Integrase
HIV
|
Infection
|
|
Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .
|
-
-
- HY-146985
-
|
|
Cathepsin
|
Neurological Disease
Cancer
|
|
Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC50 of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic .
|
-
-
- HY-147652
-
|
|
DNA Stain
|
Others
|
|
G-quadruplex DNA fluorescence probe 1 (Compound E1) is a selective G-quadruplex DNA targeting fluorescent probe. G-quadruplex DNA fluorescence probe 1 can pass through membrane and enter living cells with low cytotoxicity .
|
-
-
- HY-118762
-
|
|
Cathepsin
|
Cancer
|
|
KGP94 is a selective inhibitor of cathepsin L with an IC50 of 189 nM . KGP94 inhibits migration and invasion of metastatic carcinoma and shows low cytotoxicity (GI50=26.9 µM) against various human cell lines .
|
-
-
- HY-W110888
-
|
|
GLUT
|
Neurological Disease
|
|
Brilliant Yellow, a diazo-containing sulfonic aci, is also a potent VGLUT-specific inhibitor. Brilliant Yellow is membrane-impermeable. However, there are some Brilliant Yellow analogs with low cytotoxicity and cell penetration. Brilliant Yellow analogs work on glutamatergic transmission in hippocampal neurons .
|
-
-
- HY-100039
-
|
|
HIV
|
Infection
|
|
YYA-021 is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV activity and low cytotoxicity .
|
-
-
- HY-137498
-
|
|
Filovirus
|
Infection
|
|
EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV), with broad-spectrum activity (EC50=0.31, and 0.82 µM, respectively) and low cytotoxicity (SI>100) in HeLa cells .
|
-
-
- HY-W009245
-
|
|
HIV
|
Infection
Cancer
|
|
Bz-RS-iSer(3-Ph)-OMe (compound 2), a Taxol derivative, inhibits HSV replication cycle at low cytotoxicity, blocks mitotic divisions of Vero cells, influences M-MSV induced tumor size and affects immune response by inhibiting PHA-induced T lymphocyte proliferation .
|
-
-
- HY-162422
-
|
|
Fluorescent Dye
Pyroptosis
|
Cancer
|
|
Mito-DK is a small-molecule fluorescent dye with the capability of crosstalk-free response to polarity and mtDNA as well as mitochondrial morphology. Mito-DK has high photostability, low cytotoxicity, and good mitochondria-targeting properties. Mito-DK can be used for real-time tracking and multidimensional assessing of mitochondria-related pyroptosis in cancer cells .
|
-
-
- HY-139181
-
|
|
HDAC
|
Cancer
|
|
NR160 is a selective HDAC6 inhibitor with an IC50 value of 30 nM. NR160 shows low cytotoxicity against leukemia cell line. NR160 augments the apoptosis induction of Bortezomib (HY-10227) (proteasome inhibitor), Epirubicin (HY-13624) and Daunorubicin (HY-13062A) significantly .
|
-
-
- HY-N6622
-
|
|
Others
|
Others
|
|
Tazettine is an alkaloid with low cytotoxicity to mammalian cell lines (CC50 >100 μg/mL) .
|
-
-
- HY-151977
-
|
|
Tyrosinase
|
Cancer
|
|
Tyrosinase-IN-7 is a potent tyrosinase inhibitor with an IC50 value of 1.57 µM. Tyrosinase-IN-7 inhibits cell growth with low cytotoxicity .
|
-
-
- HY-151979
-
|
|
Tyrosinase
|
Cancer
|
|
Tyrosinase-IN-8 is a potent tyrosinase inhibitor with an IC50 value of 1.6 µM. Tyrosinase-IN-8 inhibits cell growth with low cytotoxicity .
|
-
-
- HY-152150
-
|
|
Ser/Thr Protease
|
Metabolic Disease
|
|
Thrombin inhibitor 7 is a potent FXIIa inhibitor with IC50 values of 28 nM, >132 µM for FXIIa and FXIa, respectively. Thrombin inhibitor 7 shows low cytotoxicity .
|
-
-
- HY-17605AR
-
|
GS-9883 sodium (Standard)
|
Reference Standards
HIV Integrase
HIV
|
Infection
|
|
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .
|
-
-
- HY-126275
-
|
|
ROCK
|
Cancer
|
|
HSD1590 is potent ROCK inhibitor, with IC50s of 1.22 and 0.51 nM for ROCK1 and ROCK2, respectively. HSD1590 exhibits single digit nanomolar binding to ROCK (Kds<2 nM). HSD1590 displays low cytotoxicity .
|
-
-
- HY-149207
-
|
|
Tyrosinase
|
Metabolic Disease
|
|
Tyrosinase-IN-11 is a potent tyrosinase inhibitor with IC50s of 50 nM and 64 nM for L-tyrosinase and L-dopa, respectively. Tyrosinase-IN-11 has significant antioxidant activity and low cytotoxicity. Tyrosinase-IN-11 has the potential for skin hyperpigmentation research .
|
-
-
- HY-W008864
-
|
β-Octaacetyllactose
|
Fungal
|
Infection
|
|
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
|
-
-
- HY-N7934
-
|
(-)-Trachelogenin
|
HCV
|
Infection
Neurological Disease
Inflammation/Immunology
|
|
Trachelogenin ((-)-Trachelogenin) is an HCV entry inhibitor without genotype specificity, and with low cytotoxicity. Trachelogenin inhibits HCVcc infection and HCVpp cell entry in a dose-dependent manner with an IC50 of 0.325 and 0.259 μg/mL in HCVcc and HCVpp models, respectively. Trachelogenin exhibits effective antiviral, anti-inflammatory and analgesic effects .
|
-
-
- HY-144341
-
|
|
Bacterial
|
Infection
|
|
DprE1-IN-1 is a potent, orally active DprE1 inhibitor with favorable hepatocyte stability, low cytotoxicity and low hERG channel inhibition. DprE1-IN-1 displays potent activity against both agent-susceptible and clinically isolated drug-resistant Tuberculosis strains with MICs10 CFU reduction in macrophages.
|
-
-
- HY-141646
-
|
|
Fluorescent Dye
|
Others
|
|
MIT-PZR is a mitochondria-targeted,? low cytotoxicity fluorescent probe that can be used in live cells and in vivo imaging. Ex / Em = 485 / 705 nm
|
-
-
- HY-141426
-
|
|
Enterovirus
|
Infection
|
|
MDL-860 is a broad-spectrum antipicornavirus compound that has low cytotoxicity toward human cells. MDL-860 can be used for the research of virus infection .
|
-
-
- HY-146418
-
|
|
Flavivirus
|
Infection
|
|
Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC50 of 4.5 µM. Antiviral agent 20 has low cytotoxicity .
|
-
-
- HY-N11056
-
|
|
Antibiotic
VSV
|
Infection
|
|
Justicidin C is an antiviral lignan. Justicidin C shows strong antiviral activity against vesicular stomatitis virus and low cytotoxicity against rabbit lung cells (RL-33) .
|
-
-
- HY-122274
-
|
|
Parasite
|
Infection
|
|
MMV666693 is a translation inhibitor specific for Plasmodium falciparum. MMV666693 has low cytotoxicity in human fibroblasts (IC50>32 µM) and can be used in the development of antimalarial drugs .
|
-
-
- HY-P4836
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
-
- HY-111402
-
|
Erizomycin; NSC 246134
|
Bacterial
Antibiotic
|
Infection
|
|
Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .
|
-
-
- HY-136213
-
|
|
Fluorescent Dye
|
Others
|
|
Endoplasmic reticulum dye 1 is a promising live cell imaging agent for the detection of exocytotic events at the plasma membrane. Endoplasmic reticulum dye 1 shows low cytotoxicity, resistance to photobleaching , which is ideal for imaging either short- or long-time courses .
|
-
-
- HY-W663230
-
|
|
Parasite
|
Infection
|
|
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
|
-
-
- HY-149009
-
|
|
Bcl-2 Family
Apoptosis
|
Cancer
|
|
Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells .
|
-
-
- HY-144446
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
BuChE-IN-1 (Compound 23) is a potent inhibitor of butyrylcholinesterase (BuChE). Butyrylcholinesterase (BuChE) is recently regarded as a biomarker in progressed Alzheimer’s disease (AD). BuChE-IN-1 shows low cytotoxicity and high blood brain barrier (BBB) permeability. BuChE-IN-1 is a promising BuChE inhibitor for the research of AD .
|
-
-
- HY-151448
-
|
|
Virus Protease
|
Infection
|
|
ZIKV-IN-5 (compound 5c) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=0.71 μM). ZIKV-IN-5 effectively inhibits the activity of ZIKV NS5 MTase .
|
-
-
- HY-151447
-
|
|
Virus Protease
|
Infection
|
|
ZIKV-IN-4 (compound 5b) is a low-cytotoxicity and acid-stable anti-ZIKV agent (EC50=3.49 μM). ZIKV-IN-4 effectively inhibits the activity of ZIKV NS5 MTase .
|
-
-
- HY-18620R
-
|
|
STAT
PI3K
NF-κB
MEK
ERK
Bacterial
Antibiotic
Akt
|
Inflammation/Immunology
|
|
DZ2002 (Standard) is the analytical standard of DZ2002. This product is intended for research and analytical applications. DZ2002 is an orally active, reversible and low-cytotoxic type III SAHH inhibitor (Ki=17.9 nM), with good immunosuppressive activity. DZ2002 prevents the development of experimental dermal fibrosis by reversing the profibrotic phenotype of various cell types. DZ2002 can be used in studies of autoimmune diseases such as lupus syndrome and systemic sclerosis .
|
-
-
- HY-147820
-
-
-
- HY-147806
-
|
|
Parasite
|
Infection
|
|
Antiparasitic agent-8 (Compound 9) is an antiparasitic agent against Hymenolepis nana with low cytotoxicity .
|
-
-
- HY-155071
-
|
|
Bacterial
|
Infection
|
|
MmpL3-IN-2 is an MmpL3 inhibitor with low cytotoxicity and moderate metabolic stability for tuberculosis research .
|
-
-
- HY-151356
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 122 (compound 15) is a thiourea derivative with anti-mycobacterial activity and low cytotoxicity. Antibacterial agent 122 can be used for tuberculosis-related studies .
|
-
-
- HY-146417
-
|
|
Flavivirus
|
Infection
|
|
Antiviral agent 19 (Compound 3) is a selective inhibitor against Zika virus infection with an EC50 of 1.3 µM. Antiviral agent 19 has low cytotoxicity .
|
-
-
- HY-146706
-
|
|
Bacterial
|
Infection
|
|
PqsR-IN-2 (Compound 19) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity .
|
-
-
- HY-146705
-
|
|
Bacterial
|
Infection
|
|
PqsR-IN-1 (Compound 18) is a potent PqsR (Pseudomonas aeruginosa quorum sensing transcriptional regulator) inhibitor. PqsR-IN-1 attenuates pyocyanin production and has very low cytotoxicity .
|
-
-
- HY-152669
-
|
|
Bacterial
|
Infection
|
|
Urease-IN-5 is an inhibitor of urease with an IC50 value of 1.473 µM. Urease-IN-5 has low cytotoxicity and inhibitory activity on P. vulgaris with an IC50 value of 17.78 µg/mL .
|
-
-
- HY-133207
-
|
|
Microtubule/Tubulin
|
Cancer
|
|
Myoseverin B is a microtubule assembly inhibitor capable of inhibiting the polymerization of tubulin (IC50 = 2 μM) and exhibiting low cytotoxicity in most cell types. Myoseverin B can be used in research as an antitumor agent .
|
-
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- HY-161258
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 181 (Compound 3f) is a potent ciprofloxacin cationic antibacterial agent with low cytotoxicity. The MIC values of Antibacterial agent 181 against Staphylococcus aureus and Escherichia coli are both 2 μg/mL .
|
-
-
- HY-147532
-
|
|
Cannabinoid Receptor
|
Cancer
|
|
CB2R probe 1 is a safe and green CB2R (cannabinoid 2 receptor) fluorescent probe with an Ki of 130 nM. CB2R probe 1 shows low cytotoxicity in cancer cells .
|
-
-
- HY-155734
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-55(compound 65) is a low cytotoxicity inhibtor of SARS-CoV-2 with an IC50 value of 0.3 μM, by the direct interaction with VSV-S pseudoparticles .
|
-
-
- HY-152668
-
|
|
Bacterial
|
Infection
|
|
Urease-IN-4 is an effective inhibitor of urease with an IC50 value of 1.64 µM. Urease-IN-4 has low cytotoxicity and shows inhibitory activity on P. vulgaris with an IC50 value of 15.27 µg/mL .
|
-
-
- HY-N10877
-
|
|
Others
|
Cancer
|
|
Chlorajapolide F is a nature product that could be isolated from the aerial part of Chloranthus japonicas. Chlorajapolide F has low cytotoxic activity against NCI-H460 and SMMC-7721 cell lines .
|
-
- HY-163431
-
|
|
URAT1
|
Inflammation/Immunology
|
|
URAT1 inhibitor 10 (Compound 23a) is a URAT1 inhibitor. URAT1 inhibitor 10 has oral efficacy and low cytotoxicity. URAT1 inhibitor 10 has high selectivity for OAT1 .
|
-
- HY-143762
-
|
|
Influenza Virus
|
Infection
|
|
Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1 .
|
-
- HY-157554
-
-
- HY-151560
-
|
|
Dihydroorotate Dehydrogenase
|
Cancer
|
|
hDHODH-IN-11 is a potent human dihydroorotate dehydrogenase (hDHODH) inhibitor with an IC50 value of 7.2 nM. hDHODH-IN-11 has low cytotoxicity. hDHODH-IN-11 can be used in research of acute myeloid leukemia (AML) .
|
-
- HY-149243
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
BChE-IN-16 (compound 87) is a highly potent BChE inhibitor with an IC50 of 3.8 nM for hBChE. BChE-IN-16 has low cytotoxicity, potential CNS permeability, unique adaptability and can be used in Alzheimer's disease (AD) research.
|
-
- HY-A0162R
-
|
|
Antibiotic
Reference Standards
Bacterial
|
Infection
|
|
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .
|
-
- HY-149353
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 145 (compound 1b) is an antibacterial agent depending on bacterial iron uptake pathway. Antibacterial agent 145 disrupts cytoplasmic membrane integrity and inhibits cell metabolism but exhibits low cytotoxic effects to normal cells .
|
-
- HY-155546
-
|
|
Bacterial
|
Infection
|
|
Antimicrobial agent-22 (THI 6c) is a multi-target broad-spectrum antibacterial agent. Antimicrobial agent-22 has low cytotoxicity, hemolytic property, rapid bactericidal ability and good anti-biofilm activity .
|
-
- HY-168100
-
|
|
Bacterial
|
Infection
|
|
LpxC-IN-14 (compound 6i) is a potent LpxC inhibitor. LpxC-IN-14 shows antibacterial activity. LpxC-IN-14 shows low cytotoxicity. LpxC-IN-14 shows acceptable plasma protein binding .
|
-
- HY-150754
-
|
|
Bacterial
|
Infection
|
|
FtsZ-IN-4 is an orally active FtsZ (filamenting temperature-sensitive mutant Z) inhibitor, exhibits excellent antibacterial activity. FtsZ-IN-4 shows good pharmaceutical properties with low cytotoxicity (CC50 >20 μg/mL) .
|
-
- HY-146197
-
|
|
Apoptosis
|
Cancer
|
|
Apoptotic agent-1 (Compound 8a) is an apoptotic agent with high antiproliferative activity against cancer cells and low cytotoxic effect. Apoptotic agent-1 induces over-expression of Fas receptor and Cyto C genes .
|
-
- HY-19481
-
|
|
HCV
|
Infection
|
|
HCV-371 is a highly selective, potent, and low cytotoxicity HCV NSSB (EC50 = 4.8-6.1 μM) polymerase allosteric inhibitor. HCV-371 can be used for research on hepatitis C virus infection .
|
-
- HY-19135
-
|
|
HIV Protease
|
Infection
|
|
A-77003 is an inhibitor for HIV protease, with IC50 of 0.1 to 0.2 μg/ml, for HIV-1 and HIV-2 protease. A-77003 exhibits high levels of antiretroviral activity and low cytotoxicity in vitro .
|
-
- HY-161330
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 10 (Compound 2d) is a Cephalosporin (HY-144229) derivative and exhibits antibacterial activity. Anti-MRSA agent 10 is slightly drug resistane and exhibits low cytotoxicity in cells HUVEC and HBZY-1 .
|
-
- HY-146759
-
|
|
CD73
|
Cancer
|
|
ZM514 is a potent CD73 inhibitor with IC50s of 1.39 μM and 14.65 μM for hCD73 and mCD73, respectively. ZM514 has low cytotoxicity. ZM514 can be used for researching anticancer .
|
-
- HY-168335
-
|
|
Dihydroorotate Dehydrogenase
|
Others
|
|
hDHODH-IN-16 (Compound 3t) is a human dihydroorotate dehydrogenase (hDHODH) inhibitor, with an IC50 of 0.11 μM. hDHODH-IN-16 shows very low cytotoxicity to healthy HaCaT cells, with an IC50 value greater than 200 µM .
|
-
- HY-147760
-
|
|
DYRK
|
Metabolic Disease
|
|
Dyrk1A-IN-2 (Compound 63) is a DYRK1A inhibitor with an EC50 of 37 nM. Dyrk1A-IN-2 exhibits highly potent human β-cell replication-promoting activity and low cytotoxicity .
|
-
- HY-142545
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 68 (compound 4d) is an antibacterial agent against drug-resistant Escherichia coli. Antibacterial agent 68 has low cytotoxicity and exerts strong antibacterial activities against multidrug-resistant Escherichia coli at low concentrations as 0.007 mM .
|
-
- HY-N15730
-
|
|
Drug Derivative
|
Inflammation/Immunology
|
|
3-Hydroxymycophenolic acid (Compound 5) is a microbial transformation product of Mycophenolic acid (HY-B0421) by Cunninghamella echinulata. 3-Hydroxymycophenolic acid has low cytotoxicity against AGS cells and fibroblasts. 3-Hydroxymycophenolic acid can be used for immune-mediated renal diseases research .
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-
- HY-155247
-
|
|
Tyrosinase
|
Others
|
|
Tyrosinase-IN-14 (compound 7m) is a tyrosinase inhibitor that reduces the catalytic activity of tyrosinase by changing its secondary structure. Tyrosinase-IN-14 has low cytotoxicity and anti-browning activity in fruits. Tyrosinase-IN-14 effectively inhibits banana browning during storage .
|
-
- HY-115989
-
|
|
HCV
|
Infection
|
|
HCV-IN-38 is a potent, selective and orally active HCV inhibitor (EC50=15 nM, SI=431). HCV-IN-38 has high anti-HCV activity and low cytotoxicity. HCV-IN-38 has a good safety and oral pharmacokinetic profile .
|
-
- HY-D1066
-
|
|
Fluorescent Dye
|
Others
|
|
NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. NIR-Thiol dinitrobenzenesulfonate responds to thiol with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-Thiol dinitrobenzenesulfonate is capable of imaging endogenously produced thiol in living cells and mice .
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-
- HY-147738
-
|
|
Fluorescent Dye
|
Others
|
|
SQM-NBD is a potent and selectiveAIE fluorescent probe. SQM-NBD exhibits excellent sensitivity to Cys and Hcy with the LOD of 54 nM and 72 nM, respectively.SQM-NBD has good cell permeability and low cytotoxicity. SQM-NBD has the potential for Cys/Hcy identification under physiological and pathological conditions .
|
-
- HY-147537
-
|
|
Parasite
|
Infection
|
|
Antileishmanial agent-9 (compound 16c) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 4.01 μM. Antileishmanial agent-9 has relatively low cytotoxicity in L-6 cells (IC50 = 40.1 μM) .
|
-
- HY-147536
-
|
|
Parasite
|
Infection
|
|
Antileishmanial agent-8 (compound 18) has potent and selective activity against Leishmania donovani (L. donovani) with an IC50 value of 5.64 μM. Antileishmanial agent-8 has relatively low cytotoxicity in L-6 cells (IC50=73.9 μM) .
|
-
- HY-146668
-
|
|
Cholinesterase (ChE)
|
Neurological Disease
|
|
AChE/BChE-IN-8 (Compound 5a) is an uncompetitive AChE and mixed BChE inhibitor with Ki values of 0.788 μM and 2.364 μM against Electrophorus electricus AChE (EeAChE) and equine BChE (eqBChE), respectively. AChE/BChE-IN-8 can cross the BBB and has low cytotoxicity .
|
-
- HY-155053
-
|
|
Flavivirus
DNA/RNA Synthesis
|
Inflammation/Immunology
|
|
ZIKV-IN-6 (compound 22) is an inhibitor of Zika virus (ZIKV), with low cytotoxicity (CC50＞50 μM). ZIKV-IN-6 binds to ZIKV RdRp directly and inhibits viral RNA synthesis by ZIKV NS5. ZIKV-IN-6 suppresses the excessive inflammatory response and pyroptosis .
|
-
- HY-174402
-
|
|
SARS-CoV
|
Infection
|
|
PLpro-IN-9 (Compound 14e) is a SARS-CoV-2 PLpro inhibitor with an IC50 of 12.0 μM and a KD of 1.86 μM. PLpro-IN-9 has low cytotoxicity but poor metabolic stability. PLpro-IN-9 can be used in the research of SARS-CoV-2 .
|
-
- HY-161893
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 15 (Compound 9o10) exhibits antibacterial activity, that inhibits methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 0.0625 μg/mL. Anti-MRSA agent 15 exhibits low hemolysis and low cytotoxicity. Anti-MRSA agent 15 exhibits anti-infective in mice .
|
-
- HY-144822
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 2 (compound 14) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and relatively low cytotoxicity in normal cells. Anti-MRSA agent 2 has strong ability to destroy bacterial membrane and bind to genomic DNA .
|
-
- HY-146104
-
|
|
Bacterial
|
Infection
|
|
Antimycobacterial agent-1 (compound 33) has selectively antimycobacterial activity against Mycobacterium tuberculosis (M. tuberculosis) H37Ra with a MIC value of 1 μg/ml. Antimycobacterial agent-1 has relatively low cytotoxicity in normal cells (Vero cells IC50 = 143.2 μg/ml) .
|
-
- HY-163693
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 104 (Compound 5e) exhibits antifungal activity against Sclerotinia sclerotiorum, Rhizoctonia solani and Botrytis cinerea, with EC50 of 1.52 μg/mL, 0.06 μg/mL and 15.69 μg/mL, respectively. Antifungal agent 104 exhibits low cytotoxicity to human renal cell 239A (6.28-100 mM) .
|
-
- HY-149013
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 5 (B14) is a potent MRSAagent with MIC50 values of 0.38 μg/mL and has low hERG activity with an IC50 values of >40 μM. Anti-MRSA agent 5 (B14) also has low cytotoxicity to mammal cells and unlikely to acquire bacterial resistance .
|
-
- HY-153690
-
|
|
TNF Receptor
|
Others
|
|
Progranulin modulator-1 (Compound 60) is an orally active enhancer of progranulin (PGRN) secretion. Progranulin modulator-1 enhances the potency of BV-2 cell to increase PGRN levels, has inhibitory effect on hERG and Low cytotoxicity, the PGRN EC50 and hERG IC50 were 83 and 3100 nM, respectively .
|
-
- HY-151897
-
|
|
HDAC
|
Cancer
|
|
HDAC-IN-49 is a potent unselective HDAC (HDAC) inhibitor with IC50s of 13 nM, 14 nM, 21 nM, 1880 nM, and 10 nM for HDAC1, HDAC2, HDAC3, HDAC4, and HDAC6. HDAC-IN-49 demonstrates prominent antileukemic activity with low cytotoxic activity toward healthy cells .
|
-
- HY-162956
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-97 (Compound CO-01) is an inhibitor for SARS-CoV-2 Nsp15 endoribonuclease with an IC50 of 53.5 μM. SARS-CoV-2-IN-97 exhibits low cytotoxicity in A549-AT cell with IC50 of 134 μM .
|
-
- HY-169166
-
|
|
HIV Protease
|
Infection
|
|
HIV-1 protease-IN-14 (compound 5ae) is a potent HIV-1 protease inhibitor with Ki values of 0.28, 56.9 nM for WT HIV-1 PR, R41T HIV-1 PR, respectively. HIV-1 protease-IN-14 shows low cytotoxicity .
|
-
- HY-D3430
-
|
|
Fluorescent Dye
Amyloid-β
|
Neurological Disease
|
|
PTPA-QM is a low-cytotoxicity Aβ protein probe that can be used for live-cell imaging and tissue section staining (Lys. Ex/Em = 385/615 nm). PTPA-QM can intercalate into the β-sheet layered structure of β-amyloid fibrils, form intermolecular interactions with amino acid residues, restrict intramolecular rotation and trigger fluorescence activation for imaging purposes. PTPA-QM is applicable to Alzheimer's disease-related research. Maximum excitation/emission wavelength: 448/605 nm .
|
-
- HY-N12495
-
|
|
Others
|
Cancer
|
|
Paucinervin D is a compound that can be isolated from the leaves of Garcinia paucinervis. Paucinervin D exhibits low cytotoxicity on HeLa cells (IC50 = 29.5 μM) .
|
-
- HY-N17359
-
|
|
Drug Derivative
|
Cancer
|
|
Mulberrofuran W is a 2-arylbenzofuran with a farnesyl group that exists in the root bark of Morus mongolica. It also acts as a cytotoxic agent with low cytotoxicity and weak tumor specificity .
|
-
- HY-N18247
-
|
|
Others
|
Cancer
|
|
12-Ethoxynimbolinin F is a nimbolinin-type limonoid found in the fruits of Melia toosendan. 12-Ethoxynimbolinin F shows low cytotoxic activity against cancer cells .
|
-
- HY-181508
-
|
|
Parasite
|
Infection
|
|
Antitrypanosomal agent 30 (compound 6b) is a trypanocidal agent with extremely low cytotoxicity against mouse macrophages. Antitrypanosomal agent 30 can be used for the research of Chagas disease .
|
-
- HY-P11241
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
oNCM is an antibacterial peptide. oNCM has good antibacterial activity, anti biofilm ability, anti-inflammatory effect, high stability, and low cytotoxicity. oNCM can be used for research on infectious or inflammatory conditions .
|
-
- HY-180203
-
|
|
COX
|
Cancer
|
|
COX-1/2-IN-10 (compound 3) is a dual COX-1 and COX-2 inhibitor. COX-1/2-IN-10 shows low cytotoxicity in RAW 264.7 cells .
|
-
- HY-180998
-
|
|
Bacterial
|
Infection
|
|
Antibiofilm agent-18, a tetrahydropyrid derivative is a biofilm inhibitor. Antibiofilm agent-18 can disrupts S. aureus and P. aeruginosa biofilms and has low cytotoxicity. Antibiofilm agent-18 can be used for the research of bacterial infection .
|
-
- HY-183157
-
|
|
HIV
|
Infection
|
|
HIV-1-IN-93 is a HIV-1 RNase H inhibitor with an IC50 of 6.09 μM. HIV-1-IN-93 shows low cytotoxicity and can be used in studies related to HIV-1 infection .
|
-
- HY-162914
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-96 (compound 12b) is an inhibitor of HCoV-OC43 (EC50= 97 nM) and SARS-CoV-2 (EC50= 45 nM) and low cytotoxicity (CC50> 10 μM) in Huh7 cells .
|
-
- HY-183281
-
|
|
TRP Channel
|
Others
|
|
TRPV3 antagonist-1 is a selective TRPV3 channel antagonist with an IC50 of 11.97 μM. TRPV3 antagonist-1 shows selectivity over hTRPV1, hTRPV4, hTRPA1, and hTRPM8. TRPV3 antagonist-1 shows low cytotoxicity .
|
-
- HY-183929
-
|
|
Influenza Virus
|
Infection
|
|
Antiviral agent 87 is a potent antiviral agent with low cytotoxicity in host cells. Antiviral agent 87 stabilizes prefusion HA conformation, blocks viral membrane fusion and host cell entry, and inhibits entry and replication of diverse influenza A virus subtypes. Antiviral agent 87 can be used for the research of influenza A virus infection .
|
-
- HY-N13841
-
|
|
FGFR
Raf
|
Cancer
|
|
2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose is an FGFR3 and BRAF binder, and is an isovaleryl sucrose ester that can be found in Atractylodes japonica. 2,4,3',4',6'-Penta-O-(3-methylbutanoyl)sucrose shows low cytotoxicity against cancer cells .
|
-
- HY-146496
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-20 (Compound 2d) is an orally active antitubercular agent. Antitubercular agent-20 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-20 has low cytotoxicity and good tolerance in BALB/c mice .
|
-
- HY-147505
-
|
|
Bacterial
Fungal
|
Infection
|
|
Antitubercular agent-21 (Compound 15) is an antitubercular agent with an MIC of o.4 µg/mL against M. tuberculosis H37Rv. Antitubercular agent-21 exhibits lower activity against other microorganism such as bacteria gram-positive, gram-negative or fungi. Antitubercular agent-21 shows low cytotoxicity .
|
-
- HY-134978
-
|
|
SHMT
Bacterial
|
Others
|
|
(Rac)-SHIN2 is a pyrazolopyran derivative and a serine hydroxymethyltransferase (SHMT) inhibitor. (Rac)-SHIN2 has antibacterial activity and low cytotoxicity against Hep2 cells. (Rac)-SHIN2 exerts potent antibacterial activity against both vancomycin-susceptible and vanA-type vancomycin-resistant Enterococcus .
|
-
- HY-146300
-
|
|
Bacterial
|
Infection
|
|
Mt KARI-IN-4 (compound 5c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 5.48 μM. Mt KARI-IN-4 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 72 μg/mL) .
|
-
- HY-179029
-
|
|
DNA/RNA Synthesis
Influenza Virus
|
Infection
|
|
RNA polymerase-IN-4 is a RNA polymerase inhibitor with an EC50 of 22.81 nM. RNA polymerase-IN-4 exhibits potent anti-influenza virus activity (EC50 = 3.76 nM), relatively low cytotoxicity (CC50 = 29.91 μM). RNA polymerase-IN-4 can be used for the research of infection, such as influenza virus infection .
|
-
- HY-146301
-
|
|
Bacterial
|
Infection
|
|
Mt KARI-IN-5 (compound 6c) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 4.72 μM. Mt KARI-IN-5 has inhibitory activity against Mtb H37Rv (MIC = 1.56 μM) and low cytotoxicity (HEK IC50 > 64 μg/mL)
|
-
- HY-170547
-
|
|
DNA/RNA Synthesis
HSV
EBV
CMV
|
Infection
|
|
DNA polymerase-IN-6 is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 can be used in research related to viral infections .
|
-
- HY-178979
-
|
|
Parasite
|
Infection
|
|
PIM-IN-3 (Compound 50) is an orally active new anti-intestinal worm drug. PIM-IN-3 exhibits strong inhibitory activity in vitro, especially for whipworms (IC50 = 6.6 µM). PIM-IN-3 has low cytotoxicity. PIM-IN-3 can be used in the research of gastrointestinal nematode diseases .
|
-
- HY-148172
-
|
|
HIV
HBV
Nucleoside Antimetabolite/Analog
|
Infection
|
|
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity .
|
-
- HY-184105
-
|
|
Indoleamine 2,3-Dioxygenase (IDO)
|
Cancer
|
|
IDO1-IN-36 (Compound 5a) is a selective, mixed-type IDO1 inhibitor with an IC50 of 0.72 μM against hIDO1. IDO1-IN-36 exhibits extremely low cytotoxicity in cancer cells. IDO1-IN-36 can be used for the research of breast cancer .
|
-
- HY-146299
-
|
|
Bacterial
|
Infection
|
|
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL) .
|
-
- HY-170760
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 258 (Compound 11e) is an antibacterial agent, that destory the bacteria cell membrane, and inhibits various gram-positive bacteria (MIC for Staphylococcus aureus is 1-2 μg/mL). Antibacterial agent 258 exhibits low hemolytic activity and low cytotoxicity. Antibacterial agent 258 exhibits anti-infectious efficacy in mouse models .
|
-
- HY-144663
-
|
|
Bacterial
Thymidylate Synthase
|
Infection
|
|
MtTMPK-IN-1 (compound 3) is a potent Mycobacterium tuberculosis thymidylate kinase (MtTMPK) inhibitor with an IC50 value of 2.5 μM. MtTMPK-IN-1 has moderate to weak activity against Mtb H37Rv and low cytotoxicity in human fibroblast cells MRC-5. MtTMPK-IN-1 can be used for researching tuberculosis .
|
-
- HY-114563
-
|
dFdG
|
Drug Derivative
|
Cancer
|
|
LY 223592 (Compound I-a) is a Gemcitabine (HY-17026) derivative. LY 223592 has the biological activity of highly selective inhibition of lung cancer cell proliferation (IC50 = 5.6 nM in A549 cells) and low cytotoxicity to normal cells. LY 223592 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) .
|
-
- HY-175024
-
|
|
SARS-CoV
Virus Protease
|
Infection
|
|
MC12 is a thiazole-based derivative and a SARS-CoV-2 main protease inhibitor (IC50: 77.7 nM). MC12 exhibits inhibitory effects on both SARS-CoV and SARS-CoV-2 main proteases, with low cytotoxicity and good stability. MC12 can be used in the research of anti-COVID-19 drugs .
|
-
- HY-144823
-
|
|
Bacterial
|
Infection
|
|
Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA .
|
-
- HY-W075885
-
|
trans-platinumdiamminedichloride
|
DNA Alkylator/Crosslinker
|
Others
|
|
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .
|
-
- HY-148842
-
|
|
Liposome
|
Others
|
|
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
|
-
- HY-151593
-
|
|
PROTACs
Epigenetic Reader Domain
|
Cancer
|
|
dBRD4-BD1 is a selective and durable BRD4 degrader with an DC50 value of 280 nM (Dmax=77%). dBRD4-BD1 upregulates BRD2/3 protein level and shows low cytotoxicity than iBRD4-BD1 .
|
-
- HY-146495
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-19 (Compound 1c) is an antitubercular agent. Antitubercular agent-19 shows excellent activity against MTB H37Rv and MDR-MTB strains (MIC: ＜0.016 µg/ml). Antitubercular agent-19 shows low cytotoxicity and relatively high acute lethal toxicity in BALB/c mice .
|
-
- HY-N17005
-
|
|
Others
|
Cancer
|
|
3-O-(p-Hydroxybenzoyl)serratriol is a serratene-type triterpenoid compound with low cytotoxicity against cancer cells (IC50 >100 μg/mL against three human cancer cell lines: K562, SMMC-7721, and SGC7901). 3-O-(p-Hydroxybenzoyl)serratriol can be naturally extracted from the whole plant of Palhinhaea cernua .
|
-
- HY-183332
-
|
|
Others
|
Inflammation/Immunology
|
|
YXX0248 is an orally active anti-hypoxic agent. YXX0248 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0248 exhibits low cytotoxicity. YXX0248 enhances hypoxic survival in mice. YXX0248 can be used for the research of acute mountain sickness and hypoxia-related diseases .
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-146308
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-26 (compound 9a) is a potent HIV-1 reverse transcriptase (RT) inhibitor with an IC50 value of 1.4 μM. HIV-1 inhibitor-26 has low cytotoxicity with a CC50 of 1486 μM in PBMCs. HIV-1 inhibitor-26 can be used for researching AIDS .
|
-
- HY-149014
-
|
|
Orexin Receptor (OX Receptor)
|
Neurological Disease
|
|
OX2R-IN-1 (compound 15) is a low cytotoxicity profile OX2R-IN-1 antagonist (a potential OX2R binder) with an IC50 value of 484 μM. OX2R-IN-1 (compound 15) can cross the BBB into the brain with a short half-life .
|
-
- HY-156325
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-62 (Compound R3b) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-62 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC50 values of 2.97 μM and 3.82 μM, respectively .
|
-
- HY-168959
-
|
|
Parasite
|
Infection
|
|
Antiparasitic agent-25 (Compounds 11) is an orally active antiparasitic agent. Antiparasitic agent-25 inhibits both parasite invasion and replication ability and has irreversible action against Toxoplasma gondii, significantly reducing the replication rate of Toxoplasma gondii with an IC50 value of 6.33 μM, and demonstrates low cytotoxicity with a CC50 value of 285 μM .
|
-
- HY-156337
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-63 (Compound R3e) is an inhibitor of SARS-CoV-2 replication and has low cytotoxicity. SARS-CoV-2-IN-63 inhibits viral replication in Vero E6 cells and Calu-3 cells, with EC50 values of 1.99 μM and 1.92 μM, respectively .
|
-
- HY-183331
-
|
|
Others
|
Infection
Inflammation/Immunology
|
|
YXX0237 is an orally active anti-hypoxic agent. YXX0237 upregulates mRNA expression of FGF21 and GDF15 via activation of the ISR/ATF4 transcriptional axis. YXX0237 exhibits low cytotoxicity. YXX0237 enhances hypoxic survival in mice. YXX0237 can be used for the research of acute mountain sickness and hypoxia-related diseases .
|
-
- HY-170547A
-
|
|
HSV
CMV
EBV
DNA/RNA Synthesis
|
Infection
|
|
DNA polymerase-IN-6 formic is an antiviral agent and a DNA polymerase inhibitor. DNA polymerase-IN-6 formic inhibits the replication of HCMV, HSV-1, HSV-2 and EBV. DNA polymerase-IN-6 formic exhibits low cytotoxicity in mammalian cells. DNA polymerase-IN-6 formic can be used in research related to viral infections .
|
-
- HY-139989
-
|
|
HIV
|
Infection
|
|
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50 of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM) .
|
-
- HY-146421
-
|
|
NO Synthase
NF-κB
Reactive Oxygen Species (ROS)
|
Inflammation/Immunology
|
|
Anti-inflammatory agent 21 (compound 9o) is an orally active and low cytotoxic anti-inflammatory agent, with an IC50 value of 0.76 μM for NO. Anti-inflammatory agent 21 acts via accumulation ROS and blocks the NF-κB/MAPK signaling pathway. Anti-inflammatory agent 21 can ameliorate cartilage destruction and inflammatory cell infiltration in arthritis rats model .
|
-
- HY-P11183
-
|
|
Bacterial
Toll-like Receptor (TLR)
TNF Receptor
Interleukin Related
JNK
NF-κB
|
Infection
Inflammation/Immunology
|
|
Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research .
|
-
- HY-146158
-
|
WX-081
|
Bacterial
Potassium Channel
Antibiotic
|
Infection
|
|
Fudapirine, an anti-tuberculosis agent, displays excellent anti-mycobacterial activity against M. tuberculosis H37Rv and low cytotoxicity. Fudapirine exhibits potent activity with MIC50s of 0.083 and 0.11 μg/mL for agent susceptible tuberculosis (DS-TB) and multidrug resistant tuberculosis (MDR-TB) strains. Fudapirine also inhibits hERG channel with the IC50 of 1.89 μM.
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-147556
-
|
|
Potassium Channel
|
Cancer
|
|
SK3 Channel-IN-1 (compound 7a) is a potent and specific SK3 channel modulator. SK3 Channel-IN-1 has efficient effect on breast cancer MDA-MB-435 cell migration while exhibiting low cytotoxicity in other cell lines. SK3 Channel-IN-1 can modulate ion channels’activity in cancer .
|
-
- HY-172461
-
|
|
Monoamine Oxidase
Cholinesterase (ChE)
|
Neurological Disease
|
|
MAO-IN-6 (Compound 3f) is a BBB permeable and reversible MAO-B inhibitor with an IC50 of 0.09 μM. MAO-IN-6 also exhibits certain inhibitory activities against AChE and BChE, with IC50 values of 4.48 μM and 17.03 μM, respectively. MAO-IN-6 has low cytotoxicity and can be used in the research of Alzheimer's disease .
|
-
- HY-P4836A
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-D1498
-
|
|
Fluorescent Dye
|
Others
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-156087G
-
|
|
Apoptosis
Necroptosis
|
Cancer
|
|
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .
|
-
- HY-161404
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 202 (compound 45c) is a low cytotoxicity bacterial inhibitor with good activity against Gram-negative bacteria, including Escherichia coli, Klebsiella pneumonia, especially Pseudomonas aeruginosa, (MIC (minimum inhibitory concentration)=7.8-31.25 μM). Antibacterial agent 202 can exert antibacterial activity by destroying the integrity of cell membranes and can be used in the research of bacterial infections .
|
-
- HY-N8374
-
|
|
Parasite
|
Infection
|
|
Pheanthine (Compound 2) is an antiplasmodial agent, that inhibits chloroquine-resistant Plasmodium falciparum K-1 (IC50 is 0.8 μM) and chloroquine-sensitive P. falciparum strain NF54 A19A (IC50 of 0.03 μM). Pheanthine exhibits low cytotoxicity in human lung fibrosblast (MRC-5, IC50 is 11.2 μM) and macrophages (PMM, IC50 is 8 μM) .
|
-
- HY-156087
-
|
|
Apoptosis
Necroptosis
|
Cancer
|
|
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .
|
-
- HY-112481
-
|
|
|
Inflammation/Immunology
|
|
IKK2-IN-5 is a selective IKK-2 inhibitor with an IC50 of 0.025 μM. IKK2-IN-5 inhibits the production of TNF-α in LPS (HY-D1056)-stimulated human peripheral blood mononuclear cells. IKK2-IN-5 exhibits extremely low cytotoxicity against human peripheral blood mononuclear cells .
|
-
- HY-148170
-
|
|
EBV
DNA/RNA Synthesis
Nucleoside Antimetabolite/Analog
|
Infection
|
|
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .
|
-
- HY-131983
-
|
|
Influenza Virus
|
Infection
|
|
Neuraminidase-IN-2 is an anti-influenza compounds with IC50 values of 0.28, 0.27, 11.50, 0.089 and 23.44 µM for H1N1, 09H1N1, H3N2, H5N1 and H5N2, respectively. Neuraminidase-IN-2 has antiviral activity and low cytotoxicity .
|
-
- HY-144632
-
|
|
Fungal
|
Infection
|
|
Antifungal agent 22 (compound D16) is a potential and orally active antifungal agent for CM (cryptococcal meningitis), with an IC50 of 0.5 μg/mL. Antifungal agent 22 can penetrate the blood-brain barrier and kill the C. neoformans H99 cells by destroying the integrity of fungal cell membranes. Antifungal agent 22 shows selective anti-Cryptococcus activity with good metabolic stability and low cytotoxicity .
|
-
- HY-147883
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-27 (compound 1) is a potent antitubercular agent with an IC50 value of 3.2 µM, an MIC value of 7.8 µM, an IC90 value of 7.0 µM. Antitubercular agent-27 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-27 shows effective intracellular antimycobacterial activity and low cytotoxicity .
|
-
- HY-147884
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-28 (compound 2) is a potent antitubercular agent with an IC50 value of 1.5 µM, an MIC value of 4.5 µM, an IC90 value of 2.5 µM. Antitubercular agent-28 shows antimycobacterial activity for resistant isolates of Mycobacterium tuberculosis H37Rv. Antitubercular agent-28 shows effective intracellular antimycobacterial activity and low cytotoxicity .
|
-
- HY-180387
-
|
|
SARS-CoV
Virus Protease
|
Infection
|
|
UAWJ246 is a covalent reversible inhibitor of the SARS-CoV-2 main protease (Mpro), with an IC50 of 0.045 μM and a Ki of 0.036 μM. UAWJ246 exhibits potent antiviral activity by inhibiting SARS-CoV-2 viral replication and shows low cytotoxicity. UAWJ246 can be used in research related to SARS-CoV-2 infection, such as studies on COVID-19 [1][2].
|
-
- HY-157469
-
|
NPD3064
|
HIV
|
Infection
|
|
TNT-i (NPD3064) is an inhibitor targeting M-Sec. TNT-i inhibits M-Sec-induced tunneling nanotube (TNT) formation reversibly. TNT-i reduces wild-type HIV-1 production in macrophages and M-Sec-expressing T cells. TNT-i shows low cytotoxic effects on macrophages and T cells. TNT-i can be used for the research of HIV-1 infection .
|
-
- HY-151482
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2 Mpro-IN-2 (compound GC-14) is a selective, low cytotoxic and non-covalent M pro inhibitor (IC50=0.40 μM) with good anti-SARS-CoV-2 activity (EC50=1.1 μM). SARS-CoV-2 Mpro-IN-2 can be used in COVID-19 studies .
|
-
- HY-157382
-
|
|
Cholinesterase (ChE)
Amyloid-β
MMP
|
Neurological Disease
|
|
AChE-IN-51 (compound 8C) is an orally active, non-competitive inhibitor of AChE and BChE (IC50: 84 nM, 97 nM). It also inhibits MMP-2 and amyloid Aβ1-42 aggregates (IC50: 724 nM, 302 nM). AChE-IN-51 has low cytotoxicity and in silico predicted blood-brain barrier permeability. Can be used for research on diseases such as Alzheimer's disease (AD) .
|
-
- HY-146388
-
|
|
Bacterial
ATP Synthase
|
Infection
|
|
Mtb ATP synthase-IN-1 (compound 6ab) is a potent Mycobacterium tuberculosis (Mtb) ATP synthase inhibitor, with MIC of 0.452-0.499 μg/mL against Mtb. Mtb ATP synthase-IN-1 has good metabolic stability, low cytotoxicity (Vero IC50 > 64 μg/mL), and acceptable oral bioavailability. Mtb ATP synthase-IN-1 can be used for researching anti-mycobacterium .
|
-
- HY-N3497
-
|
|
NF-κB
DNA/RNA Synthesis
Parasite
Apoptosis
|
Infection
Cancer
|
|
Isochamaejasmin is a biflavonoid with anti-cancer, antiplasmodial and insecticidal activities. Isochamaejasmin displays a potent NF-κB (NF-κB) activation activity. Isochamaejasmin could cause DNA damage and induce apoptosis via the mitochondrial pathway in AW1 cells . Isochamaejasmin also has a moderate antiplasmodial activity (IC50 of 7.3 μM for P. falciparum) and relatively low cytotoxicity (CC50 of 29.0 μM) .
|
-
- HY-15221
-
|
|
Apoptosis
Histone Demethylase
MDM-2/p53
|
Cardiovascular Disease
Cancer
|
|
Methylstat is a potent histone demethylases inhibitor. Methylstat shows anti-proliferative activity with low cytotoxicity. Methylstat induces apoptosis and cell cycle arrest at G0/G1 phase. Methylstat increases the expression of p53 and p21 protein levels. Methylstat inhibits angiogenesis induced by various cytokines. Methylstat can be used as a chemical probe for addressing its role in angiogenesis .
|
-
- HY-DY1095
-
|
Fluo-3-pentaacetoxymethyl ester (solution)
|
Fluorescent Dye
|
Others
|
Fluo-3AM (solution) is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
Solvent and concentration: DMSO: 5 mM
|
-
- HY-155540
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2 3CLpro-IN-14 (compound 11j) is an orally active SARS-CoV-2 3CLpro inhibitor. SARS-CoV-2 3CLpro-IN-14 shows significant anti-SARS-CoV-2 activity (EC50 = 0.18 μM) and low cytotoxicity (CC50 > 50 μM) in Vero E6 cells .
|
-
- HY-15096
-
MKT-077
Maximum Cited Publications
16 Publications Verification
FJ-776
|
Fluorescent Dye
HSP
|
Cancer
|
|
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .
|
-
- HY-179116
-
|
BS2463
|
Parasite
|
Infection
|
|
BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC50 of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC50 >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection .
|
-
- HY-158379
-
|
|
Parasite
|
Infection
|
|
Antiparasitic agent-22 (Compound 24) is a pan antiparasitic agent, that inhibits T. Brucei, L. infantum, L. tropica promastigotes (IC50 of 2.41, 5.95, 8.98 μM), L. infantum amastigotes (IC50 of 8.18 μM) and P. falciparum W2 strain (IC50 of 0.155 μM). Antiparasitic agent-22 exhibits low cytotoxicity against THP1, with CC50 of 64.16 μM .
|
-
- HY-155981
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2 3CLpro-IN-18 (Compound 3C) is a covalent SARS-CoV-2 3CLpro inhibitor (IC50s: 0.478 μM). SARS-CoV-2 3CLpro-IN-18 inhibits SARS-CoV-2 in Vero E6 cells (EC50= 2.499 μM) with low cytotoxicity (CC50 > 200 μM) .
|
-
- HY-D3220
-
|
|
Fluorescent Dye
Amyloid-β
|
Neurological Disease
|
|
PTO-41 is a blood-brain barrier-permeable near-infrared fluorescent probe that targets β-amyloid oligomers (Aβ Oligomers, AβOs) with a Kd of 349 nM. PTO-41 exhibits low cytotoxicity, high sensitivity to β-amyloid oligomers in in vitro phantom imaging, and can be rapidly cleared from the brain. PTO-41 is applicable to the research of Alzheimer's disease (Ex/Em = 538 nM/680 nM) .
|
-
- HY-146557
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-16 (Compound 5q) is an antitubercular agent with MIC90 values of 0.40, 20.11, 23.51, 19.62, 10.93 and 13.62 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-16 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
|
-
- HY-161260
-
|
|
P-glycoprotein
|
Cancer
|
|
P-gp inhibitor 20 (compound H27) is a low cytotoxicity P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 20 inhibits the efflux function of P-gp in a dose-dependent manner (without affecting the expression of P-gp), thereby reversing the multidrug resistance (MDR) of MCF-7/ADR cells, with an IC50 value of 46.6 nM. P-gp inhibitor 20 can be used for cancer research .
|
-
- HY-146226
-
|
|
Enterovirus
|
Infection
|
|
Viral 2C protein inhibitor 1 (compound 6aw) is a potent and broad-spectrum enterovirus antiviral agent, inhibiting viral 2C protein. Viral 2C protein inhibitor 1 inhibits multiple strains of EV-D68, EV-A71 and CVB3 with EC50s of 0.1~3.6 µM, and exhibits high selectivity index and relatively low cytotoxicity .
|
-
- HY-P11057
-
|
|
Fluorescent Dye
|
Others
|
|
FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu 2+ and S 2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu 2+ and S 2-, respectively) (Ex=488 nm, Em=525 nm), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .
|
-
- HY-181558
-
|
|
Others
|
Cancer
|
|
Anticancer agent 303 is a selective, orally active anticancer agent belonging to the pyrazolopyridine derivatives. Anticancer agent 303 exhibits low cytotoxicity to healthy cells, with a selective window of approximately 2-fold between cancer cells and healthy cells. Anticancer agent 303 produces detectable systemic exposure in mice following intraperitoneal or oral administration. Anticancer agent 303 effectively inhibits the proliferation of prostate cancer and breast cancer cells .
|
-
- HY-146556
-
|
|
Bacterial
|
Infection
|
|
Antitubercular agent-15 (Compound 5n) is an antitubercular agent with MIC90 values of 0.73, 7.69, 9.38, 18.80, 7.53 and 7.31 μg/mL against M. tuberculosis H37Rv, CF16, CF61, CF76, CF152 and CF161, respectively. Antitubercular agent-15 shows low cytotoxicity against macrophages and pulmonary fibroblasts .
|
-
- HY-149431
-
|
|
HSP
Potassium Channel
|
Cancer
|
|
NDNA4 (compound 17) is a selective inhibitor of Hsp90α (IC50: 0.34 μM). NDNA4 is a permanently charged analog with low membrane permeability and low cytotoxicity against Ovcar-8 and MCF-10A ((IC50 >100 μM)). NDNA4 prevents disruption of hERG channel maturation without generating a heat shock response or causing degradation of Hsp90α-dependent client proteins .
|
-
- HY-182347
-
|
|
Parasite
|
Infection
|
|
LSPN954 (compound 4i) is an indole-based peptidomimetic antiplasmodial agent that exhibits submicromolar activity against both sensitive and multidrug-resistant *Plasmodium falciparum* strains, with low cytotoxicity to human cells and a high selectivity index. LSPN954 shows slow-acting inhibitory activity, allowing the initial development of *Plasmodium* followed by morphological changes, and its activity is independent of the inhibition of plastid-dependent isoprenoid biosynthesis. LSPN954 can be used in malaria research .
|
-
- HY-170688
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Antibacterial agent 119 (Compound 21 g) is an antibacterial candidate against Methicillin (HY-121544)-resistant Staphylococcus aureus (MICs less than 1 μg/mL against tested strains). Antibacterial agent 119 induces ROS production. Antibacterial agent 119 also acts on the bacterial cell membrane to cause membrane breakage. Antibacterial agent 119 exhibits potent antibacterial activity with low cytotoxicity, rapid bactericidal ability, and good in vivo antibacterial activity .
|
-
- HY-146057
-
|
|
Bacterial
|
Infection
|
|
Antituberculosis agent-2 (Compound 8d) is an antituberculosis agent against agent-sensitive and multidrug-resistant tuberculosis. Antituberculosis agent-2 shows anti-tuberculosis activity with MIC values of 0.454, 1.757 and 1.644 μg/mL against M. tuberculosis H37Rv, 13946 and 14862, respectively. Antituberculosis agent-2 displays favorable mouse and human microsomal stability, low cytotoxicity, and acceptable oral bioavailability .
|
-
- HY-146957
-
|
|
Virus Protease
Flavivirus
|
Cancer
|
|
ZIKV-IN-1 is a potent zika virus inhibitor with an EC50 of 2.8 μM and EC90 of 6.8 μM. ZIKV-IN-1 shows anti-ZIKV activity with low cytotoxicity. ZIKV-IN-1 shows a strong affinity to ZIKV RdRp domain . ZIKV-IN-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
|
-
- HY-135646
-
|
|
Influenza Virus
|
Infection
Inflammation/Immunology
|
|
Eleutheroside B1, a coumarin compound, has a wide spectrum of anti-human influenza virus efficacy, with an IC50 value of 64-125 µg/ml. Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation. Eleutheroside B1 inhibits the mRNA expression of several chemokine genes and the influenza nucleoprotein (NP) gene, and exhibits low cytotoxicity. Antiviral and anti-inflammatory activities .
|
-
- HY-W001023A
-
|
5A8HQ dihydrochloride; 5AHQ dihydrochloride
|
Proteasome
NF-κB
|
Cancer
|
|
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) dihydrochloride is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline dihydrochloride can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline dihydrochloride can be used for the research of cancer, such as leukemia .
|
-
- HY-146018
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-23 (compound 12a) is a highly potent HIV-1 non-nucleoside reverse transcriptase inhibitor, with EC50s of 24.9 nM and 10.4 nM for HIV-1 WT and HIV-1 K103N, respectively. HIV-1 inhibitor-23 has low cytotoxicity (CC50 > 221 μM) and a favorable in vitro microsomal stability .
|
-
- HY-W001023
-
|
5A8HQ; 5AHQ
|
Proteasome
NF-κB
|
Cancer
|
|
5-Amino-8-hydroxyquinoline (5A8HQ; 5AHQ) is an orally active non-competitive 20S proteasome inhibitor. 5-Amino-8-hydroxyquinoline can inhibit NF-κB activity and induce cancer cells death and shows low cytotoxicity towards normal hematopoietic cells. 5-Amino-8-hydroxyquinoline can be used for the research of cancer, such as leukemia .
|
-
- HY-N0674A
-
|
13-Methylpalmatine chloride
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Infection
Cancer
|
|
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline chloride shows strong anti-malarial effects (IC50?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .
|
-
- HY-115829
-
|
|
HIV
|
Infection
|
|
APA-H-MPO hydrochloride is an inhibitor of PCAF bromodomain/Tat-AcK50 interaction with potential for anti-HIV/AIDS. APA-H-MPO hydrochloride can effectively inhibit the binding of PCAF bromodomain to Tat-AcK50. APA-H-MPO hydrochloride showed low cytotoxicity in preliminary cell studies. APA-H-MPO hydrochloride is considered a potential candidate for a promising inhibitory strategy targeting the host cell protein PCAF BRD to block HIV replication .
|
-
- HY-175015
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2 Mpro-IN-46 (Compound 12) is a SARS-CoV-2 main protease inhibitor with an IC50 of ∼25 μM. SARS-CoV-2 Mpro-IN-46 has potent antiviral activity with low cytotoxicity against SARS-CoV-2 (IC50: 7.4 μM). SARS-CoV-2 Mpro-IN-46 can be used for coronaviruses COVID-19 research .
|
-
- HY-161985
-
|
|
PPAR
|
Metabolic Disease
|
|
PPARγ-IN-3 (compound 9ga) is a potent and orally active PPARγ inhibitor. PPARγ-IN-3 reduces triglyceride (TG) accumulation with low cytotoxicity. PPARγ-IN-3 preventes the excessive growth of body weight and lessened fat mass as well as liver mass, decreases lipid accumulation in the liver and blood. PPARγ-IN-3 has the potential for the research of diet-induced obesity .
|
-
- HY-179126
-
|
|
Cholinesterase (ChE)
Monoamine Oxidase
|
Inflammation/Immunology
|
|
BChE/MAO-A-IN-1 (compound 7j) is a BChE/MAO-A inhibitor. BChE/MAO-A-IN-1 exhibits inhibitory activity against BChE (IC50 = 0.03 nM) and MAO-A (IC50 = 0.32 nM), while also having inhibitory effects on MAO-B. BChE/MAO-A-IN-1 has good anti glycation, antioxidant activity, and low cytotoxicity. BChE/MAO-A-IN-1 can be used in the research of diabetes and Alzheimer's disease .
|
-
- HY-N0674B
-
|
13-Methylpalmatine (hydroxyl)
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Infection
Inflammation/Immunology
Cancer
|
|
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.
|
-
- HY-116971
-
|
|
Histone Methyltransferase
Apoptosis
|
Cancer
|
|
DCG066 is an inhibitor of lysine methyltransferase G9a. DCG066 can bind directly to G9a and inhibit methyltransferase activity in vitro. DCG066 decreases di-methylation levels of histone H3 lysine 9 (H3K9Me2), inhibits cell proliferation and induces cell apoptosis. DCG066 displays low cytotoxicity in leukemia cell lines with high levels of G9a expression, including K562 .
|
-
- HY-N0674
-
|
13-Methylpalmatine
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Infection
Cancer
|
|
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities . Dehydrocorydaline shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
|
-
- HY-174320
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-112 (Compound 6f) is an orally active and non-peptidic SARS-CoV-2 main protease inhibitor with an IC50 of 6.48 μM. SARS-CoV-2-IN-11 has potent antiviral activity with low cytotoxicity against WI-38 cells (IC50: 53.81 μM). SARS-CoV-2-IN-112 can be used for coronaviruses COVID-19 research .
|
-
- HY-178822
-
|
|
Drug Derivative
|
Cancer
|
|
AQ-13 (Compound 7) is a Chloroquine (HY-17589A) analogue with anti-breast cancer property. AQ-13 shows antiproliferative activities against MDA-MB231 and MCF7 with GI50 of 27.81 and 17.85 μM. AQ-13 shows low cytotoxicity against non-cancerous breast epithelial cells MCF10A (GI50 = 65.26 μM). AQ-13 can be used for the research of breast cancer .
|
-
- HY-178476
-
|
|
Bacterial
Reactive Oxygen Species (ROS)
|
Infection
|
|
Anti-MRSA agent 36 (Compound III13) is an antibacterial agent with strong anti MRSA activity (MIC = 1 μg/mL). Anti-MRSA agent 36 targets phosphatidylglycerol (PG) on bacterial membranes, disrupting membrane integrity, leading to DNA leakage and increased ROS. Anti-MRSA agent 36 has advantages such as low cytotoxicity, low hemolysis, difficulty in inducing drug resistance, and good plasma stability. Anti-MRSA agent 36 can be used for the study of skin abscess and systemic infection models .
|
-
- HY-156119
-
|
|
Mixed Lineage Kinase
Necroptosis
|
Metabolic Disease
Cancer
|
|
MLKL-IN-6 (compound P28) is a mixed lineage kinase inhibitor targeting Mixed Lineage Kinase domain-like (MLKL). MLKL-IN-6 inhibits cell necrosis. MLKL-IN-6 inhibits MLKL phosphorylation and oligomerization during cell necrosis, inhibits immune cell death, and reduces the expression of adhesion factors. MLKL-IN-6 has low cytotoxicity, and it inhibits hepatic stellate cell activation, reduces liver fibrosis marker levels, and has anti-fibrotic effects .
|
-
- HY-N4238
-
|
13-Methylpalmatine nitrate
|
Bcl-2 Family
Caspase
PARP
p38 MAPK
Parasite
Autophagy
|
Infection
Cancer
|
|
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. . Dehydrocorydaline nitrate shows strong anti-malarial effects (IC50 =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .
|
-
- HY-151917
-
|
|
Apoptosis
Carbonic Anhydrase
Phosphodiesterase (PDE)
|
Cancer
|
|
Enpp/Carbonic anhydrase-IN-2 (compound 1i) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.13, 1.07, 0.74, 0.33, 0.68 for NPP1, NPP2, NPP3, CA-IX, CA-XII respectively. Enpp/Carbonic anhydrase-IN-2 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-2 induces Apoptosis .
|
-
- HY-124623
-
|
|
Parasite
|
Infection
|
|
DNDI-8219 (compound 58) is a potent selective and orally active trypanocidal agent, possessing inhibitory activity against Trypanosoma cruzi (T. cruzi) with an IC50 of 0.4 μM. DNDI-8219 has low cytotoxicity (L6 cells IC50 > 100 μM). DNDI-8219 can effectively cure chronic T. cruzi infection and markedly reduce parasite burdens in mouse model. DNDI-8219 has good solubility, metabolic stability and safety.
|
-
- HY-139781
-
|
|
PD-1/PD-L1
Apoptosis
|
Cancer
|
|
PD-L1-IN-1 (Compound 10) is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly exhibits low cytotoxicity in healthy cells .
|
-
- HY-180228
-
|
|
Orthopoxvirus
|
Infection
|
|
MPXV p37 protein-IN-1 is a potent and orally active inhibitor of monkeypox virus (MPXV) p37 protein. MPXV p37 protein-IN-1 exhibits potent antivial activity against MPXV with an EC50 of 12.14 nM, with low cytotoxicity (CC50 = 304.63 μM). MPXV p37 protein-IN-1 demonstrates low toxicity and good tolerability in mice. MPXV p37 protein-IN-1 can be used for the research of anti-MPXV .
|
-
- HY-N11725
-
|
|
Fc Receptor (FcR)
|
Inflammation/Immunology
|
|
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .
|
-
- HY-W011762
-
|
|
Apoptosis
|
Cancer
|
|
VK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity .
|
-
- HY-146000
-
|
|
Influenza Virus
|
Inflammation/Immunology
|
|
Influenza virus-IN-3 (compound 9) is a potent and selective influenza virus inhibitor with IC50s of 0.88, 0.10, 5.5, 0.51 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-3 shows antiviral and NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-3 shows low cytotoxicity with an CC50 of >200 µM .
|
-
- HY-178111
-
|
|
Bacterial
|
Infection
|
|
AcrB-IN-6 is an effective AcrB inhibitor. AcrB-IN-6 The compound inhibits the function of bacterial multidrug efflux pumps, thereby significantly enhancing the antibacterial activity of various antibiotics. AcrB-IN-6 achieves 32-fold MIC reductions in wild-type E. coli BW25113. AcrB-IN-6 exhibits excellent synergistic antibacterial effects, low cytotoxicity and hemolytic properties. AcrB-IN-6 can be used for researching anti-resistant bacteria .
|
-
- HY-16712
-
|
|
TGF-β Receptor
|
Cancer
|
|
LDN-214117 is an orally active ALK2 inhibitor with well-tolerated and good brain penetration. LDN-214117 has a high selectivity and low cytotoxicity for ALK2 with an IC50 value of 24 nM. LDN-214117 also is a specific bone morphogenetic proteins (BMPs) signaling inhibitor and has relatively selective inhibition for BMP6 with an IC50 value of 100 nM. LDN-214117 can be used for the research of fibrodysplasia ossificans progressiva (FOP), diffuse intrinsic pontine glioma (DIPG) .
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-
- HY-146005
-
|
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Microtubule/Tubulin
|
Neurological Disease
Inflammation/Immunology
|
|
Tau-aggregation and neuroinflammation-IN-1 is a potent tau-aggregation and neuroinflammation inhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reduced NO release in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats .
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-
- HY-152552
-
|
|
α-synuclein
|
Neurological Disease
|
|
α-Synuclein inhibitor 8 is an active inhibitor of α-Synuclein with an IC50 value of 2.5 µM. α-Synuclein inhibitor 8 has highly inhibition on the aggregation and disaggregation of α-Synuclein fibers. α-Synuclein inhibitor 8 reduces the formation of inclusions in neurons that can repairs damage neurons and improves Parkinson’s disease (PD)-like symptoms. α-Synuclein inhibitor 8 has high antioxidant activity and low cytotoxicity .
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-
- HY-178005
-
|
|
EGFR
VEGFR
Apoptosis
|
Cancer
|
|
EGFR-IN-174 is a potent EGFR inhibitor (IC50 = 0.17 μM) and also displays VEGFR-2 inhibition (IC50 = 0.2007 μM). EGFR-IN-174 exhibits potent anticancer effects with low cytotoxicity to normal cells. EGFR-IN-174 induces G2/M and Pre-G1 phase arrest and significantly triggers apoptosis. EGFR-IN-174 can be used in cancer research, such as colorectal carcinoma, hepatocellular carcinoma, and breast cancer .
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-
- HY-180578
-
|
|
SARS-CoV
|
Infection
|
|
MWAC-3429 is a potent SARS-CoV-2 Nsp13 helicase inhibitor. MWAC-3429 inhibits SARS-CoV-2 and SARS-CoV1 with EC50s of 5.39 (nLuc assay) and 17.00 μM (CPE assay), respectively, while showing low cytotoxicity in A549-hACE2 cells (CC50 > 50 μM). MWAC-3429 can be used for SARS-CoV-infection research .
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-
- HY-151916
-
|
|
Apoptosis
Carbonic Anhydrase
Phosphodiesterase (PDE)
|
Cancer
|
|
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis .
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-
- HY-149058
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Influenza Virus
|
Infection
|
|
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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-
- HY-179019
-
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HDAC
Microtubule/Tubulin
Apoptosis
Caspase
|
Neurological Disease
Cancer
|
|
HDAC-IN-94 is a potent, selective HDAC6 inhibitor (IC50 = 4.5 nM). HDAC-IN-94 shows >1000-fold selectivity over HDAC8 and shows minimal activity against other isoforms (HDAC1-3/10). HDAC-IN-94 induces α-tubulin hyperacetylation, apoptosis, and G2/M cell cycle arrest, exhibiting potent anti-tumor efficacy with low cytotoxicity. HDAC-IN-94 can be used for neuroblastoma and glioblastoma research .
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-
- HY-146017
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-22 (compound 11a) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 3.63 μM for HIV-1 RT. HIV-1 inhibitor-22 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 0.304 μM and 0.201 μM, also has low cytotoxicity (CC50 > 227 μM)
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-
- HY-112146
-
MMG-11
5 Publications Verification
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
MMG-11 is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 µM for Pam3CSK4-induced hTLR2/1 and 5.7 µM for Pam2CSK4-induced hTLR2/6 responses .
|
-
- HY-146352
-
|
|
HIV
|
Infection
Inflammation/Immunology
|
|
HIV-1 inhibitor-28 (compound 14j2) is a highly potent and selective HIV-1 inhibitor with an EC50 of 58 nM for WT HIV-1 strain and an IC50 of 3.37 μM for HIV-1 WT reverse transcription (RT). HIV-1 inhibitor-28 exhibits relatively low cytotoxicity in MT-4 cells (CC50 = 38.6 μM). HIV-1 inhibitor-28 can be used for researching AIDS .
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-
- HY-175016
-
|
|
Endogenous Metabolite
|
Infection
Metabolic Disease
|
|
NADH-IN-3 (Compound C4-1) is a NADH inhibitor with a MIC of 4 μg/mL (13.042 μM) for type II NADH dehydrogenase of Mycobacterium tuberculosis (Mtb). NADH-IN-3 significantly interrupts ATP synthesis, shows potent inhibitory effects against mono (Rifampicin (HY-B0272) and Isoniazid (HY-B0329)) and multi drug-resistant (Mtb) strains and an anti-bactericidal activity against HepG2 cells with low cytotoxicity (SI: 16.52) .
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-
- HY-161461
-
|
|
Amylases
|
Neurological Disease
|
|
E234G HYPE-IN-1 (Compound I2.10) is an inhibitor of AMPylation directed by the Huntingtin-interacting protein E (HYPE), possessing low micromolar bioactivity, low cytotoxicity, and blood-brain barrier permeability. E234G HYPE-IN-1 can inhibit the AMPylation of B-cell immunoglobulin-binding protein (BiP), the primary substrate of HYPE. E234G HYPE-IN-1 is suitable for development as a HYPE-specific therapeutic agent for clinical conditions such as neurodegenerative diseases and diabetes .
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-
- HY-146339
-
|
|
HIV
|
Infection
Inflammation/Immunology
|
|
HIV-1 inhibitor-27 (compound 5) is a potent HIV-1 inhibitor with IC50s of 16 μM, 0.5 μM and 0.39 μM for HIV-1 YU2, NL4-3 and 89.6 strain, respectively. HIV-1 inhibitor-27 has low cytotoxicity with a CC50 of 128 μM in TZM-bl cells. HIV-1 inhibitor-27 can be used for researching AIDS .
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-
- HY-178456
-
|
|
Parasite
Reactive Oxygen Species (ROS)
Apoptosis
|
Infection
|
|
Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS)-mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research .
|
-
- HY-181489
-
|
|
SARS-CoV
|
Infection
Cancer
|
|
SARS-CoV-2 3CLpro-IN-35 is a SARS-CoV-2 3CLpro inhibitor with an IC50 of 0.15 μM. SARS-CoV-2 3CLpro-IN-35 inhibits the proliferation of bladder cancer cells, exerts anti-SARS-CoV-2 activity, and exhibits low cytotoxicity in fibroblasts. SARS-CoV-2 3CLpro-IN-35 is applicable to research related to SARS-CoV-2 infection and bladder cancer .
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-
- HY-182784
-
|
|
Bacterial
|
Infection
|
|
Antibacterial agent 336 is an antibacterical agent with broad-spectrum inhibitory activity against Gram-negative and Gram-positive bacteria. Antibacterial agent 336 binds tightly via its pyridine group to the carboxyl group, Lys-465 residue, and Leu-480 residue of the MsbA protein, interfering with bacterial outer membrane synthesis, and exerts concentration-dependent bactericidal activity against bacterial. Antibacterial agent 336 has low cytotoxicity to normal human liver cells. Antibacterial agent 336 can be used for the research of bacterial infections .
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-
- HY-175309
-
|
|
URAT1
|
Metabolic Disease
|
|
URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout .
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-
- HY-112146A
-
|
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
|
MMG-11 quarterhydrate is a potent and selective human TLR2 antagonist with low cytotoxicity. MMG-11 quarterhydrate inhibits both TLR2/1 and TLR2/6 signaling with IC50s of 1.7 μM for Pam3CSK4-induced hTLR2/1 and 5.7 μM for Pam2CSK4-induced hTLR2/6 responses .
|
-
- HY-174373
-
|
|
SARS-CoV
Angiotensin-converting Enzyme (ACE)
|
Infection
|
|
SARS-CoV-2-IN-113 (Compound 24) is a sulfonohydrazide derivative against SARS-CoV-2 infection with an IC50 of 8.320 μM. SARS-CoV-2-IN-113 exerts potent antiviral effects by inhibiting the entry and replication of SARS-CoV-2, and downregulating the expression of genes and proteins such as Spike, ACE-2, and RdRp. SARS-CoV-2-IN-113 has high selectivity and low cytotoxicity, and can be used in the research of SARS-CoV-2 .
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-
- HY-W075885R
-
|
trans-platinumdiamminedichloride (Standard)
|
Biochemical Assay Reagents
Reference Standards
|
Others
|
|
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.
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-
- HY-182294
-
|
|
URAT1
|
Metabolic Disease
Inflammation/Immunology
|
|
HYJ-2 is a URAT1 inhibitor and urate-lowering agent. HYJ-2 inhibits URAT1-mediated urate transport and interacts with key residues within the URAT1 binding pocket. HYJ-2 reduces serum urate levels in hyperuricemic mice without inducing liver or kidney injury. HYJ-2 shows low cytotoxicity to hepatocytes and renal cells. HYJ-2 does not significantly induce hepatocyte apoptosis or mitochondrial dysfunction. HYJ-2 can be used in studies related to hyperuricemia and gout .
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-
- HY-175517
-
|
|
Parasite
|
Infection
|
|
PEX5-PEX14 PPI-IN-3 (Compound 7) is an inhibitor of the PEX5-PEX14 protein-protein interaction (PPI) with an EC50 of 95 μM. PEX5-PEX14 PPI-IN-3 has an EC50 of 7.2 μM against Trypanosoma brucei (T. brucei). PEX5-PEX14 PPI-IN-3 exhibits low cytotoxicity towards HepG2 cells and possesses antiparasitic activity .
|
-
- HY-174385
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2-IN-114 (Compound 36) is an antiviral agent. SARS-CoV-2-IN-114 exhibits significant antiviral activity against both the SARS-CoV-2 original strain and the Delta variant. SARS-CoV-2-IN-114 has an EC50 of 0.29 μM for inhibiting CPE of the SARS-CoV-2 original strain, and that for the Delta variant is 5.77 μM. SARS-CoV-2-IN-114 has low cytotoxicity and can be used in coronavirus research .
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-
- HY-176217
-
|
|
Biochemical Assay Reagents
DNA/RNA Synthesis
|
Cancer
|
|
dA-NHbenzylOCF3 is a DNA-targeted radiosensitizer that enhances the sensitivity of tumor cells to X-rays via the dissociative electron attachment (DEA) mechanism. dA-NHbenzylOCF3 shows low cytotoxicity to normal cells and mainly localizes to the cytoplasm and nucleus after entering cells. dA-NHbenzylOCF3 exerts its radiosensitizing effect by inducing cell cycle arrest at the radiation-sensitive G2/M phase. dA-NHbenzylOCF3 can be used for radiosensitization research on malignant tumors such as prostate cancer and breast cancer .
|
-
- HY-162492
-
|
|
Influenza Virus
|
Infection
|
|
Influenza A virus-IN-14 (Compound 37) is an inhibitor for influenza virus type A (IAV), which inhibits H1N1 with an EC50 of 23 nM. Influenza A virus-IN-14 exhibits low cytotoxicity with CC50 of more than 100 μM. Influenza A virus-IN-14 inhibits cytopathic effect and improves the survival rates of cell Calu3. Influenza A virus-IN-14 exhibits synergistic activity with the neuraminidase inhibitor Oseltamivir (HY-13317). Influenza A virus-IN-14 exhibits poor pharmacokinetic properties in CD-1 mouse .
|
-
- HY-146019
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-24 (compound S-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 9.5 nM. HIV-1 inhibitor-24 has high antiretroviral activity against WT HIV-1 with an EC50 of 1.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 9.07 μM in MT-4 cells. HIV-1 inhibitor-24 is well tolerated at a dose of 2 g/kg in mice and has a significant cardiovascular safety .
|
-
- HY-146015
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-21 (compound 9b) is a potent HIV-1 non-nucleoside reverse transcriptase (RT) inhibitor, with an IC50 value of 0.55 μM for HIV-1 RT. HIV-1 inhibitor-21 has antiretroviral activity against HIV-1 WT and K103N strains with EC50s of 12.7 nM and 10.4 nM, and has relatively low cytotoxicity (MT-4 cells CC50 =10.2 μM) .
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-
- HY-172264
-
|
|
Antibiotic
Bacterial
DNA/RNA Synthesis
|
Infection
|
|
XT17 is an anthrone compound with broad-spectrum antibacterial activity. It exerts its antibacterial effect by disrupting the cell wall and inhibiting DNA synthesis. XT17 exhibits weak hemolytic activity, low cytotoxicity against mammalian cell lines, and a low frequency of drug resistance. Meanwhile, XT17 shows in vivo efficacy in a mouse corneal infection model induced by Staphylococcus aureus or Pseudomonas aeruginosa. Further docking studies have confirmed that XT17 can form a stable complex with bacterial gyrase. XT17 can be used in the research of the anti - infection field .
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-
- HY-155527
-
|
|
SARS-CoV
|
Infection
|
|
SARS-CoV-2 Mpro-IN-9 (compound c7) is a nonpeptidic, noncovalent SARS-CoV-2 M pro inhibitor (IC50=0.085 μM), with improved physicochemical and drug metabolism and pharmacokinetics (DMPK) properties. SARS-CoV-2 Mpro-IN-9 inhibits viral replication (EC50=1.10 μM) in SARS-CoV-2-infected Vero E6 cells, while exhibits low cytotoxic effects (CC50>50 μM) .
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-
- HY-178773
-
|
|
Sirtuin
Apoptosis
|
Infection
|
|
SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with IC50s of 5.3 and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis .
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-
- HY-174444
-
|
|
PROTACs
HDAC
|
Cancer
|
|
PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs. ( Pink: HDAC ligand : (HY-174471), Blue: E3 ligase CRBN Ligand (HY-131717), E3 ligase ligand-linker conjugate (HY-174473)) .
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-
- HY-175838
-
|
|
P-glycoprotein
|
Cancer
|
|
P-gp-IN-32 is a P-glycoprotein (P-gp) inhibitor. P-gp-IN-32 exhibits low cytotoxicity and potent multidrug resistance (MDR) reversal activity against Doxorubicin (HY-15142A) in MCF7/ADR cells (IC50 = 0.11 μM, reversal fold (RF) = 215.9). P-gp-IN-32 can bind to P-gp directly, induce a conformation change of P-gp and inhibit the efflux function. P-gp-IN-32 can be used for the research of cancer, such as breast cancer .
|
-
- HY-179580
-
|
|
PPAR
Phosphodiesterase (PDE)
|
Inflammation/Immunology
|
|
EL244 is a dua Autotaxin (ATX) (IC50 = 50 nM) inhibitor and PPARγ (IC50 = 1.3 μM; Kd = 1.3 μM) agonist. EL244 demonstrates low cytotoxicity in human HepG2 cells (EC50 = 81.2 μM) with minimal inhibition of the cardiac hERG potassium channel (12% at 25 μM). EL244 significantly reduces pulmonary Lysophosphatidic Acid (LPA) levels, attenuates fibrosis, and restores respiratory function with limited systemic absorption in vivo. EL244 can be used for idiopathic pulmonary fibrosis and interstitial lung disease (ILD) research .
|
-
- HY-146353
-
|
|
HIV
|
Infection
Inflammation/Immunology
|
|
HIV-1 inhibitor-29 (compound 14d2) is a potent HIV-1 inhibitor with an EC50 of 2.18 μM for HIV-1 IIIB. HIV-1 inhibitor-29 has high anti-resistance profile toward F227L/V106A strain (EC50 = 0.974 μM), and exhibits low cytotoxicity in MT-4 cells (CC50 = 211 μM). HIV-1 inhibitor-29 can be used for researching AIDS .
|
-
- HY-N3700
-
|
Rutaceline
|
Bacterial
HIV
TNF Receptor
Interleukin Related
|
Infection
Inflammation/Immunology
|
|
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .
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-
- HY-181029
-
|
|
Tyrosinase
|
Neurological Disease
Inflammation/Immunology
|
|
Tyrosinase-IN-49 (Compound 12) is a potent and mixed-type chalcone-based tyrosinase inhibitor with an IC50 of 0.19 μM. Tyrosinase-IN-49 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-49 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu 2+ to Cu +, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-49 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-49 shows antibrowning effects to improve food quality and can be used for research of food preservation .
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-
- HY-151799
-
|
|
p62
E1/E2/E3 Enzyme
Apoptosis
|
Cancer
|
|
P62-RNF168 agonist-1 (compound 5a) is a low cytotoxicity P62-RNF168 agonist that enhances the interaction between P62 and RNF168. P62-RNF168 agonist-1 induces a reduction in H2A ubiquitination mediated by RNF168 and impairs homologous recombination-mediated DNA repair. P62-RNF168 agonist-1 also inhibits the growth of xenograft tumors in mice in a dose-dependent manner .
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-
- HY-N18316
-
|
|
Others
|
Cancer
|
|
(2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone is a biflavonoid compound present in the whole herb of Selaginella doederleinii. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone exhibits antiproliferative activity against non-small cell lung cancer cells (IC50 = 3.1-6.8 μM) with low cytotoxicity toward normal cells. (2''S)-6''-Methyl-2'',3''-Dihydrodelicaflavone can be used in studies related to non-small cell lung cancer .
|
-
- HY-146001
-
|
|
Influenza Virus
|
Inflammation/Immunology
|
|
Influenza virus-IN-4 (compound 11e) is a potent influenza virus neuraminidase inhibitor with IC50s of 3.4, 0.094, 0.79, 0.077 µM for H5N1, H5N2, H5N6, H5N8, respectively. Influenza virus-IN-4 shows NA (neuraminidase enzyme)-inhibitory activity. Influenza virus-IN-4 shows low cytotoxicity with an CC50 of >200 µM. Influenza virus-IN-4 shows no obvious toxicity at the dose of 1500 mg/kg in mice .
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-
- HY-181419
-
|
|
Bacterial
|
Infection
|
|
Antimycobacterial agent-16 is a pyrazinamide derivative and antimycobacterial agent with a selectivity index >25 against HepG2 cells.Antimycobacterial agent-16 does not undergo hydrolysis by mycobacterial pyrazinamidase.Antimycobacterial agent-16 exerts activity against Mycobacterium tuberculosis H37Rv, multidrug-resistant Mycobacterium tuberculosis strains, and Mycobacterium kansasii.Antimycobacterial agent-16 shows no inhibitory activity against mycobacterial enoyl-ACP reductase (InhA).Antimycobacterial agent-16 has low cytotoxicity against HepG2 cells.Antimycobacterial agent-16 can be used for the research of tuberculosis .
|
-
- HY-147881
-
|
|
Influenza Virus
|
Infection
|
|
Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with EC50 values of 3.29, 2.45 µM for A/HK/68 (H3N2, M2-WT), A/WSN/33 (H1N1, M2-S31N) strain, respectively. Anti-Influenza agent 3 shows low cytotoxicity for MDCK epithelial cells. Anti-Influenza agent 3 inhibits the M2 WT and S31N ion channel conductivity .
|
-
- HY-181028
-
|
|
Tyrosinase
|
Neurological Disease
Inflammation/Immunology
|
|
Tyrosinase-IN-48 (Compound 3) is a potent and competitive chalcone-based tyrosinase inhibitor with an IC50 of 0.49 μM. Tyrosinase-IN-48 has potent antioxidant potential with significant DPPH and ABTS radical scavenging capacity. Tyrosinase-IN-48 can chelate the binuclear copper ions in the active center of tyrosinase and reduce Cu 2+ to Cu +, thereby reducing the catalytic activity of the enzyme. Tyrosinase-IN-48 has low cytotoxicity for HEK293 cells and zebrafish embryo. Tyrosinase-IN-48 shows antibrowning effects to improve food quality and can be used for research of food preservation .
|
-
- HY-158138
-
|
|
PARP
Topoisomerase
Apoptosis
|
Cancer
|
|
TOPOI/PARP-1-IN-1 (Compound B6) is an orally active, low cytotoxic TOPOI/PARP dual inhibitor with an IC50 value of 0.09 μM for PARP1. TOPOI/PARP-1-IN-1 can effectively inhibit the proliferation and migration of cancer cells. TOPOI/PARP-1-IN-1 also causes cell cycle arrest in the G0/G1 phase and induces apoptosis. The tumor growth inhibition rate (TGI) of TOPOI/PARP-1-IN-1 in mice is 75.4% .
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-
- HY-148817
-
|
|
WDR5
|
Cancer
|
|
WDR5-0102 is an inhibitor of WDR5. WDR5-0102 specifically targets the WIN site of WDR5, disrupts the WDR5-MLL1 interaction, and reduces the histone methyltransferase activity of MLL1. WDR5-0102 exerts dose-dependent toxicity on MDSC-like cells and reduces their osteopontin levels, while showing extremely low cytotoxicity to pancreatic cancer cells. WDR5-0102 can be used in the research of related diseases such as acute myeloid leukemia, lymphoid leukemia, biphenotypic leukemia and pancreatic cancer .
|
-
- HY-163783
-
|
|
Casein Kinase
|
Infection
|
|
CSNK2-IN-1 is a potent and selective CSNK2 inhibitor with IC50 of 1.7 nM and 0.66 nM for CSNK2A1 and CSNK2A2, respectively. CSNK2-IN-1 has antiviral activity against beta-coronaviruses such as SARS-CoV-2 and MHV. CSNK2-IN-1 has good solubility, metabolic stability, and low cytotoxicity, but its plasma concentration in vivo decreases rapidly and is insufficient to achieve pharmacological effects. CSNK2-IN-1 can be used in the research of antiviral drug development .
|
-
- HY-133135
-
|
|
CHIKV
Nucleoside Antimetabolite/Analog
|
Infection
|
CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC50 of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC50 of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083). CHIKV-IN-1 can be used in research on anti-Chikungunya virus .
|
-
- HY-17648
-
|
|
BCRP
|
Cancer
|
|
MBL-II-141 is potent ABCG2 inhibitor with an IC50 of 0.11 μM. MBL-II-141 inhibits the transport function of ABCG2 in a non-competitive manner, preventing ABCG2 from pumping substrates (such as Irinotecan (HY-16562)) out of the cells, thereby increasing the accumulation of drugs within the cells. MBL-II-141 has no effect on ABCB1 (P-gp) and ABCC1 (MRP1) and has extremely low cytotoxicity (IG50 > 100 μM). MBL-II-141 can be used for the study of multidrug resistance (MDR) cancers .
|
-
- HY-D1701
-
|
|
Fluorescent Dye
|
Others
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
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-
- HY-180194
-
|
|
Calcium Channel
|
Cardiovascular Disease
|
|
SERCA2a activator 2 (Compound 25) is a potent SERCA2a (cardiac type) activator, which also has an activating effect on SERCA1a (skeletal muscle type). SERCA2a activator 2, under [Ca²⁺]MAX conditions activates the ATPase activity of SERCA2a and promotes Ca²⁺ uptake, with its EC₅₀ values being 4 μM and 0.80 μM respectively. SERCA2a activator 2 also exhibits consistent activating effects under more physiological [Ca²⁺]MID conditions. SERCA2a activator 2 has low cytotoxicity and can be used for research on diseases such as heart failure .
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-
- HY-157404
-
|
|
Pim
|
Cancer
|
|
Pim-1/2 kinase inhibitor 2 (compound 5b) is a competitive PIM-1 and PIM-2 kinase inhibitor with IC50s of 1.31 μM and 0.67 μM, respectively. Pim-1/2 kinase inhibitor 2 shows in-vitro low cytotoxicity against normal human lung fibroblast Wi-38 cell line and potent in-vitro anticancer activity against myeloid leukaemia (NFS-60), liver (HepG-2), prostate (PC-3), and colon (Caco-2) cancer cell lines .
|
-
- HY-101898
-
|
Indo-1 Acetoxymethyl ester
|
Fluorescent Dye
|
Others
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
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-
- HY-136783
-
|
|
Parasite
|
Infection
|
|
G6PD-IN-2 is a Plasmodium falciparum glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC50 value of 0.2 μM. G6PD-IN-2 exerts weak inhibitory activity on Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase (PfGluPho) with an IC50 value of 22.0 μM. G6PD-IN-2 inhibits growth of Plasmodium falciparum 3D7 strain and exhibits low cytotoxicity in hepatocytes. G6PD-IN-2 can be used for the research of malaria .
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-
- HY-130612
-
|
|
Epigenetic Reader Domain
PROTACs
|
Cancer
|
|
PROTAC BRD2/BRD4 degrader-1 (compound 15) is a potent and selective BET protein BRD4 and BRD2 degrader, connected by ligands for Cereblon and BET. PROTAC BRD2/BRD4 degrader-1 rapidly induces reversible, long-lasting, and unexpectedly selective removal of BRD4 and BRD2 over BRD3. It effectively inhibits solid tumors with low cytotoxic effect. PROTAC BRD2/BRD4 degrader-1 is composed of the BET inhibitor, a linker, and the ligand thalidomide for cereblon (CRBN)/cullin 4A .
|
-
- HY-109659
-
|
|
Biochemical Assay Reagents
DNA Alkylator/Crosslinker
|
Others
|
|
1-(3-Aminopropyl)-4-methylpiperazine is a capping agent. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (β-amino ester) (PBAE) poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) undergoes electrostatic interactions with anionic molecules such as DNA and exhibits low cytotoxicity. The 1-(3-Aminopropyl)-4-methylpiperazine-capped Poly (1,4-butanediol diacrylate-co-4-amino-1-butanol) PBAE effectively delivers nucleic acids in various systems .
|
-
- HY-181066
-
|
|
Angiotensin-converting Enzyme (ACE)
SARS-CoV
|
Infection
|
|
ACE2-SP PPI-IN-1 is an inhibitor of the interaction between the SARS-CoV-2 spike protein and ACE2, with an IC50 of 2162.77 nM. ACE2-SP PPI-IN-1 exhibits low cytotoxicity in human fibroblasts. ACE2-SP PPI-IN-1 binds to the interface region between the spike protein RBD and ACE2, reducing the flexibility of the critical receptor-binding loop and maintaining the structural compactness of the spike protein. ACE2-SP PPI-IN-1 can be used for research related to SARS-CoV-2 .
|
-
- HY-151574
-
|
|
Ser/Thr Kinase
Parasite
GSK-3
|
Infection
|
|
PfGSK3/PfPK6-IN-1 is a dual Plasmodium serine/threonine kinase inhibitor, with an IC50 of 97 nM against PfGSK3 and 8 nM against PfPK6 of Plasmodium falciparum. PfGSK3/PfPK6-IN-1 inhibits the proliferation of blood-stage parasites of Plasmodium falciparum 3D7. PfGSK3/PfPK6-IN-1 shows low cytotoxicity to hepatocytes at a concentration of 200 nM, and reduces cell viability at a concentration of 2 μM. PfGSK3/PfPK6-IN-1 is applicable to malaria-related research .
|
-
- HY-174444A
-
|
|
PROTACs
HDAC
|
Cancer
|
|
PROTAC HDAC degrader-2 TFA is the trifluoroacetate salt of PROTAC HDAC degrader-2. PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs. ( Pink: HDAC ligand : (HY-174471), Blue: E3 ligase CRBN Ligand (HY-131717), E3 ligase ligand-linker conjugate (HY-174473)) .
|
-
- HY-D1244
-
|
|
Fluorescent Dye
|
Cardiovascular Disease
Inflammation/Immunology
|
|
CO probe 1 (probe 2) is a highly efficient fluorescent CO probe (Ex=493 nm) with an allyl ether reaction site. In the presence of PdCl₂, CO reduces Pd 2+ to Pd 0, triggering a Tsuji-Trost reaction that removes the allyl protecting group, releases fluorescein, and generates a significant fluorescence signal. CO probe 1 has high selectivity, rapid response (fluorescence enhancement of 150 times within 20 minutes), and low cytotoxicity, and can be used for real-time imaging of CO in living cells. CO probe 1 may be used to study pathological mechanisms involving CO signaling regulation, such as inflammation, vascular disease, or cancer .
|
-
- HY-20559
-
|
|
Drug Intermediate
|
Cancer
|
|
4-Chloro-3-nitrobenzoic acid is a benzoic acid derivative and an important intermediate for the synthesis of anticancer agents. 4-Chloro-3-nitrobenzoic acid shows low cytotoxicity against HepG2, A549 and HeLa cancer cells in vitro (>10,000 μM). 4-Chloro-3-nitrobenzoic acid can block thymidine uptake and inhibit lymphocyte growth. 4-Chloro-3-nitrobenzoic acid serves as a ligand for Cu (II) complexes and is used in the preparation of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives .
|
-
- HY-B0420A
-
|
ABOB hydrochloride
|
Influenza Virus
HCV
HSV
Apoptosis
Caspase
|
Infection
|
|
Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels .
|
-
- HY-172965
-
|
|
SARS-CoV
Virus Protease
|
Infection
Inflammation/Immunology
|
|
SARS-CoV-2 Mpro-IN-43 (Compound 1) is a coronavirus main protease (Mpro) inhibitor (IC50: 72 μM). SARS-CoV-2 Mpro-IN-43 interacts with key residues in the active site of Mpro via non-covalent binding, exerting its anti-coronavirus effect. SARS-CoV-2 Mpro-IN-43 exhibits moderate to low cytotoxicity, with CC50 values of 13.24, 41.02, and 42.26 µM in HaCaT, HEK293T, and HepG2 cells, respectively. SARS-CoV-2 Mpro-IN-43 can be used in anti-SARS-CoV-2 research .
|
-
- HY-181034
-
|
|
Reverse Transcriptase
HIV
|
Infection
|
|
NNRT-IN-15 (Compound 16a) is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor. NNRT-IN-15 shows an EC50 of 3 nM for WT HIV-1 and inhibits seven mutant strains (L100I, K103N, Y181C, etc.) (EC50 = 8.2-43.4 nM). NNRT-IN-15 has low cytotoxicity against MT-4 cells (CC50 = 196.46 μM). NNRT-IN-15 also inhibit WTHIV-1RT and hERG with IC50 values of 0.7599 μM and 27.455 μM. NNRT-IN-15 can be used for research of HIV-1 infection .
|
-
- HY-181820
-
|
|
Topoisomerase
DNA Glycosylase
Bacterial
|
Infection
|
|
Topoisomerase IV-IN-3 is a Staphylococcus aureus Topoisomerase IV inhibitor, DNA gyrase inhibitor and antibacterial agent. Topoisomerase IV-IN-3 has IC50 values of 1.32 μM and 0.48 μM against topoisomerase IV, and 0.88 μM and 0.54 μM against DNA gyrase. Topoisomerase IV-IN-3 inhibits decatenation, ATPase, and supercoiling activities of its target enzymes. Topoisomerase IV-IN-3 exerts antibacterial activity against Gram-positive and Gram-negative bacterial strains. Topoisomerase IV-IN-3 exhibits low cytotoxicity toward human fibroblast cells. Topoisomerase IV-IN-3 can be used for the research of bacterial infections .
|
-
- HY-W016937
-
|
ABOB
|
Influenza Virus
HSV
HCV
Apoptosis
Caspase
|
Infection
Inflammation/Immunology
|
|
Moroxydine (ABOB) is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
- HY-178053
-
|
|
Aryl Hydrocarbon Receptor
Cytochrome P450
Interleukin Related
|
Inflammation/Immunology
|
|
AHR agonist 10 is a potent AHR agonist (EC50 = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1. AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6, IL-8, S100A9, TLR4, TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research .
|
-
- HY-B0420AR
-
|
ABOB hydrochloride (Standard)
|
Influenza Virus
HCV
HSV
Apoptosis
Caspase
Reference Standards
|
Infection
|
|
Moroxydine (ABOB) hydrochloride (Standard) is the analytical standard of Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine (ABOB) hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels.
|
-
- HY-179504
-
|
|
Phosphodiesterase (PDE)
TNF Receptor
|
Inflammation/Immunology
|
|
PDE4B-IN-6 (compound 4i) is a potent and selective PDE4B inhibitor with an IC50 of 7.42 nM. PDE4B-IN-6 shows ~195- and ~169-fold selectivity for PDE4B over PDE4A (IC50 = 1540 nM) and PDE4C (IC50 = 1260 nM), respectively. PDE4B-IN-6 increases cAMP level and suppresses TNF-α expression. PDE4B-IN-6 shows favorable antioxidant profiles and low cytotoxicity. PDE4B-IN-6 can be used for chronic obstructive pulmonary disease (COPD) research .
|
-
- HY-182349
-
|
|
Bcl-2 Family
|
Cancer
|
|
Bax activator-2 (compound 27c) is a pro-apoptotic agent targeting BAX, with an IC50 of 0.30 μmol/L against human BAX. Bax activator-2 binds to the trigger site of BAX and induces its conformational change. Bax activator-2 induces mitochondrial depolarization, cytochrome c release, caspase-3/9 cleavage and PARP cleavage, thereby initiating apoptosis. Bax activator-2 exhibits cytotoxicity against various cancer cell lines, shows reduced cytotoxicity in BAX-knockout A549 cells, and has low cytotoxicity against non-cancerous cell lines. Bax activator-2 can be used in studies related to acute myeloid leukemia and solid tumors .
|
-
- HY-169920
-
|
|
HIV
Reverse Transcriptase
|
Infection
|
|
HIV-1 inhibitor-79 (Compound 3k) is an HIV inhibitor that exhibits significant inhibitory activity against HIV-1 and its common mutant strains (with IC50 values of 1.9, 1.9, 8.7, and 11 nM against HIV-1, K103, L100I, and E138K, respectively), and has low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). Additionally, HIV-1 inhibitor-79 also shows antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and significantly inhibits the activity of HIV-1 reverse transcriptase (IC50 = 25 nM) .
|
-
- HY-183801
-
|
|
Phosphatase
Apoptosis
|
Cancer
|
|
Cu2LCl2(H2O) acts as a proteasome inhibitor and protein tyrosine phosphatase inhibitor, with antiproliferative and apoptosis-inducing effects. Cu2LCl2(H2O) exhibits low cytotoxicity against normal cells and remarkable in vivo antitumor efficacy. Cu2LCl2(H2O) inhibits proteasome activity in colon cancer cells, and suppresses PTP1B and TCPTP activities in breast cancer cells. Cu2LCl2(H2O) can be used in the research of colon cancer, breast cancer and liver cancer .
|
-
- HY-W713297
-
|
ABOB hydrochloride-d8
|
Influenza Virus
Isotope-Labeled Compounds
HCV
HSV
Apoptosis
Caspase
|
Infection
|
|
Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
- HY-130178
-
|
|
Endogenous Metabolite
|
Infection
|
|
CL-385319 is an N-substituted piperidine compound with inhibitory activity against H5N1 avian influenza A virus infection. CL-385319 exhibited an IC50 of 27.03±2.54 μM against infection of highly pathogenic H5N1 virus in Madin-Darby canine kidney cells (MDCK). CL-385319 had low cytotoxicity with a CC50 of 1.48 mM and was able to inhibit the entry of pseudoviruses carrying H5N1 strains from different sources, but had no inhibitory effect on the entry of VSV-G pseudotyped particles. Pseudoviruses with the M24A mutation in HA1 or the F110S mutation in HA2 were resistant to CL-385319, indicating that these two residues in the cavity region may be critical for the binding of CL-385319 .
|
-
- HY-181556
-
|
|
JNK
TGF-beta/Smad
Cadherin
|
Inflammation/Immunology
|
|
JNK3-IN-10 is a blood-brain barrier-impermeable JNK3 inhibitor (IC50=0.257 nM) with over 400-fold selectivity over JNK1. JNK3-IN-10 blocks the JNK3-mediated signaling pathway downstream of TGF-β1, inhibits TGF-β1-induced phosphorylation of c-Jun, reduces the expression of pro-fibrotic markers, and restores the expression of the epithelial protein E-cadherin. JNK3-IN-10 exhibits low cytotoxicity, anti-fibrotic, cytoprotective and renoprotective effects, and alleviates albuminuria, glomerulosclerosis and podocyte foot process fusion. JNK3-IN-10 can be used for the research of chronic kidney disease, glomerulosclerosis and adriamycin-induced nephropathy .
|
-
- HY-179021
-
|
|
COX
Lipoxygenase
|
Cancer
|
|
COX-2/15-LOX-IN-7 is a potent, selective and orally active dual inhibitor of COX-2 and 15-LOX with IC50 values of 0.022 and 1.19 μM. COX-2/15-LOX-IN-7 also inhibits COX-1 with an IC50 value of 28.081μM. COX-2/15-LOX-IN-7 has low cytotoxicity against human colorectal cancer HT-29 and HCT116 cell lines (IC50 >100 μM for both). COX-2/15-LOX-IN-7 exhibits non-ulcerogenic performance. COX-2/15-LOX-IN-7 can be used for the research of cancer .
|
-
- HY-N4183
-
|
|
Apoptosis
Caspase
Estrogen Receptor/ERR
|
Cardiovascular Disease
Infection
|
|
Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
|
-
- HY-146019A
-
|
|
HIV
|
Infection
|
|
HIV-1 inhibitor-25 (compound R-12a) is a highly potent HIV-1 reverse transcriptase, with an IC50 value of 0.1061 μM. HIV-1 inhibitor-25 has high antiretroviral activity against WT HIV-1 with an EC50 of 13.6 nM, and exhibits relatively low cytotoxicity with a CC50 of 33.13 μM in MT-4 cells. HIV-1 inhibitor-25 also has inhibitory activity against HIV-1 mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L+V106A) with EC50 of 0.1961 ~ 5.8136 μM. HIV-1 inhibitor-25 can be used for researching AIDS .
|
-
- HY-N17896
-
|
|
Tyrosinase
|
Cancer
|
|
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products .
|
-
- HY-181413
-
|
|
PROTACs
Histone Methyltransferase
Bcl-2 Family
Caspase
PARP
|
Cancer
|
|
PROTAC EZH2 Degrader-44 (compound 60) is a highly efficient PROTAC degrader targeting the EZH2-PRC2 complex. By recruiting the CRBN E3 ligase and relying on the proteasome system, PROTAC EZH2 Degrader-44 simultaneously induces the degradation of core components EZH2, SUZ12 and EED, thereby significantly reducing the levels of H3K27me3 and CARM1. PROTAC EZH2 Degrader-44 exerts antiproliferative effects through a dual mechanism: on the one hand, it triggers mitochondrial dysfunction leading to decreased membrane potential; on the other hand, it strongly promotes apoptosis by regulating Bcl-2 family proteins (upregulating Bax, Caspase-3 and PARP, and downregulating Bcl-2). PROTAC EZH2 Degrader-44 exhibits only extremely low cytotoxicity in human normal mammary epithelial, liver and kidney cells, showing a favorable safety window. PROTAC EZH2 Degrader-44 is an ideal tool molecule for exploring the mechanisms of targeted therapy for triple-negative breast cancer .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-15096
-
MKT-077
Maximum Cited Publications
16 Publications Verification
FJ-776
|
Fluorescent Dyes
|
|
MKT-077 (FJ-776), a highly water-soluble mitochondrial dye, has significant antitumor activity . MKT-077 exhibits low cytotoxicity, and inhibits broad-spectrum human cancer cell lines (colon cancer, breast cancer, pancreatic cancer). MKT-077 inhibits the growth of tumor in nude mice enograft tumor model. Ex/Em=488/543 nm .
|
-
- HY-D0716
-
|
Fluo-3-pentaacetoxymethyl ester
|
Fluorescent Dyes
|
|
Fluo-3 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-D1498
-
|
|
Fluorescent Dyes
|
|
Mag-Fluo-4 AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Mag-Fluo-4 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-101898
-
|
Indo-1 Acetoxymethyl ester
|
Fluorescent Dyes
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
|
-
- HY-D1244
-
|
|
Fluorescent Dyes
|
|
CO probe 1 (probe 2) is a highly efficient fluorescent CO probe (Ex=493 nm) with an allyl ether reaction site. In the presence of PdCl₂, CO reduces Pd 2+ to Pd 0, triggering a Tsuji-Trost reaction that removes the allyl protecting group, releases fluorescein, and generates a significant fluorescence signal. CO probe 1 has high selectivity, rapid response (fluorescence enhancement of 150 times within 20 minutes), and low cytotoxicity, and can be used for real-time imaging of CO in living cells. CO probe 1 may be used to study pathological mechanisms involving CO signaling regulation, such as inflammation, vascular disease, or cancer .
|
-
- HY-141646
-
|
|
Fluorescent Dyes
|
|
MIT-PZR is a mitochondria-targeted,? low cytotoxicity fluorescent probe that can be used in live cells and in vivo imaging. Ex / Em = 485 / 705 nm
|
-
- HY-136213
-
|
|
Fluorescent Dyes
|
|
Endoplasmic reticulum dye 1 is a promising live cell imaging agent for the detection of exocytotic events at the plasma membrane. Endoplasmic reticulum dye 1 shows low cytotoxicity, resistance to photobleaching , which is ideal for imaging either short- or long-time courses .
|
-
- HY-D1701
-
|
|
Fluorescent Dyes
|
|
Calcium is an important part of the human body, usually in the form of calcium, a large number of bones and teeth of the human body, a small amount of blood and tissues.
MCE calcium ion detection probe can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence, in addition, Mag-indo-1/AM and Mag-Fluo-4 AM at a certain concentration (usually 5 mM) can effectively identify intracellular magnesium ions .
|
-
- HY-D1066
-
|
|
Fluorescent Dyes
|
|
NIR-Thiol dinitrobenzenesulfonate has both absorption and emission in the NIR region. NIR-Thiol dinitrobenzenesulfonate responds to thiol with a large turn-on NIR fluorescence signal upon excitation in the NIR region. NIR-Thiol dinitrobenzenesulfonate is capable of imaging endogenously produced thiol in living cells and mice .
|
-
- HY-101902
-
|
Quin-2 acetoxymethyl ester
|
Fluorescent Dyes
|
|
Quin-2AM is a fluorecent Ca 2+ chelator, with high affinity for calcium. Quin-2AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
|
-
- HY-156087G
-
|
|
Fluorescent Dyes
|
|
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .
|
-
- HY-D3430
-
|
|
Fluorescent Dyes
|
|
PTPA-QM is a low-cytotoxicity Aβ protein probe that can be used for live-cell imaging and tissue section staining (Lys. Ex/Em = 385/615 nm). PTPA-QM can intercalate into the β-sheet layered structure of β-amyloid fibrils, form intermolecular interactions with amino acid residues, restrict intramolecular rotation and trigger fluorescence activation for imaging purposes. PTPA-QM is applicable to Alzheimer's disease-related research. Maximum excitation/emission wavelength: 448/605 nm .
|
-
- HY-DY1095
-
|
Fluo-3-pentaacetoxymethyl ester (solution)
|
Fluorescent Dyes
|
Fluo-3AM (solution) is a fluorecent Ca 2+ chelator, with high affinity for calcium. Fluo-3 AM can specifically identify intracellular calcium ions, with high sensitivity, low cytotoxicity, increased AM acetylmethyl ester can enter the cell well, after being sheared by the intracellular esterase stay in the cell to bind to calcium ions, produce strong fluorescence .
Solvent and concentration: DMSO: 5 mM
|
-
- HY-D3220
-
|
|
Fluorescent Dyes
|
|
PTO-41 is a blood-brain barrier-permeable near-infrared fluorescent probe that targets β-amyloid oligomers (Aβ Oligomers, AβOs) with a Kd of 349 nM. PTO-41 exhibits low cytotoxicity, high sensitivity to β-amyloid oligomers in in vitro phantom imaging, and can be rapidly cleared from the brain. PTO-41 is applicable to the research of Alzheimer's disease (Ex/Em = 538 nM/680 nM) .
|
| Cat. No. |
Product Name |
Type |
-
- HY-148842
-
|
|
Biochemical Assay Reagents
|
|
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
|
-
- HY-W110888
-
|
|
Biochemical Assay Reagents
|
|
Brilliant Yellow, a diazo-containing sulfonic aci, is also a potent VGLUT-specific inhibitor. Brilliant Yellow is membrane-impermeable. However, there are some Brilliant Yellow analogs with low cytotoxicity and cell penetration. Brilliant Yellow analogs work on glutamatergic transmission in hippocampal neurons .
|
-
- HY-W075885
-
|
trans-platinumdiamminedichloride
|
Biochemical Assay Reagents
|
|
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .
|
-
- HY-W008864
-
|
β-Octaacetyllactose
|
Biochemical Assay Reagents
|
|
Lactose octaacetate shows mild to moderate antifungal activity against some fungi, but it has low or no activity against bacteria and yeast. Lactose octaacetate shows low cytotoxicity to MDBK cells, Hep-2 and MDCK cells. Lactose octaacetate has antiviral activity against PV-1 .
|
-
- HY-20559
-
|
|
Biochemical Assay Reagents
|
|
4-Chloro-3-nitrobenzoic acid is a benzoic acid derivative and an important intermediate for the synthesis of anticancer agents. 4-Chloro-3-nitrobenzoic acid shows low cytotoxicity against HepG2, A549 and HeLa cancer cells in vitro (>10,000 μM). 4-Chloro-3-nitrobenzoic acid can block thymidine uptake and inhibit lymphocyte growth. 4-Chloro-3-nitrobenzoic acid serves as a ligand for Cu (II) complexes and is used in the preparation of 10H-pyrazino[2,3-b][1,4]benzothiazine derivatives .
|
-
- HY-156087G
-
|
|
Biochemical Assay Reagents
|
|
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .
|
-
- HY-W075885R
-
|
trans-platinumdiamminedichloride (Standard)
|
Biochemical Assay Reagents
|
|
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.
|
| Cat. No. |
Product Name |
Target |
Research Area |
-
- HY-P11057
-
|
|
Fluorescent Dye
|
Others
|
|
FGGH is a water-soluble peptide-based probe. FGGH performs the sequential detection of Cu 2+ and S 2- by fluorescence and colorimetry with high sensitivity (LOD: 1.42 and 22.2 nM for Cu 2+ and S 2-, respectively) (Ex=488 nm, Em=525 nm), and images both two ions in living cells and zebrafish models with low cytotoxicity. FGGH can be used for in vivo imaging and environmental pollution monitoring research .
|
-
- HY-P4836A
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-P4836
-
|
|
Parasite
|
Infection
|
|
LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
|
-
- HY-A0162R
-
|
|
Antibiotic
Reference Standards
Bacterial
|
Infection
|
|
Bictegravir (sodium) (Standard) is the analytical standard of Bictegravir (sodium). This product is intended for research and analytical applications. Bictegravir sodium is a potent inhibitor of HIV-1 integrase, with an IC50 of 7.5 nM. Bictegravir sodium exhibits potent and selective anti-HIV activity and low cytotoxicity .
|
-
- HY-P11183
-
|
|
Bacterial
Toll-like Receptor (TLR)
TNF Receptor
Interleukin Related
JNK
NF-κB
|
Infection
Inflammation/Immunology
|
|
Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research .
|
-
- HY-P11241
-
|
|
Bacterial
|
Infection
Inflammation/Immunology
|
|
oNCM is an antibacterial peptide. oNCM has good antibacterial activity, anti biofilm ability, anti-inflammatory effect, high stability, and low cytotoxicity. oNCM can be used for research on infectious or inflammatory conditions .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
-
- HY-N0674
-
-
-
- HY-N2193
-
-
-
- HY-N4183
-
|
|
Structural Classification
Flavonoids
Classification of Application Fields
Flavones
Leguminosae
Phenols
Polyphenols
Plants
Glycyrrhiza uralensis Fisch.
Disease Research Fields
Source Classification
Cancer
|
Apoptosis
Caspase
Estrogen Receptor/ERR
|
|
Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
|
-
-
- HY-N0674A
-
-
-
- HY-135646
-
-
-
- HY-N0674B
-
-
-
- HY-N4238
-
-
-
- HY-N6622
-
-
-
- HY-N7934
-
-
-
- HY-N11056
-
-
-
- HY-111402
-
|
Erizomycin; NSC 246134
|
Natural Products
Microorganisms
Source Classification
|
Bacterial
Antibiotic
|
|
Pyridomycin (Erizomycin) is a selective and low cytotoxic inhibitor of Mycobacterium tuberculosis that effectively targets InhA. Pyrdomycin is also an antibiotic that can be obtained from metabolites of Dactylosporangium fulvum. Pyrdomycin can be used in the study of bacterial infections such as tuberculosis .
|
-
-
- HY-W663230
-
|
|
Natural Products
Microorganisms
Source Classification
|
Parasite
|
|
Eugenitin is a polyketide isolated from the fungus Mycoleptodiscus indicus that is related to the South American medicinal plant. Eugenitin inhibits Leishmania major with LD50=39.9 μM. Eugenitin has low cytotoxicity (IC50 >131 μM) against several human cancer cell lines .
|
-
-
- HY-N3700
-
|
Rutaceline
|
Structural Classification
Alkaloids
Rutaceae
Plants
Isoquinoline Alkaloids
Zanthoxylum simulans Hance
Source Classification
|
Bacterial
HIV
TNF Receptor
Interleukin Related
|
|
Decarine (Rutaceline) is a benzophenanthridine alkaloid found in Zanthoxylum species. Decarinewith shows anti-inflammatory, antimycobacterial, and anti-HIV activity. Decarine inhibits NO, TNF-α, IL-1β, IL-6, and IL-8 production in inflammatory cell models. Decarine inhibits growth of Mycobacterium tuberculosis strains, reduces intracellular Mycobacterium tuberculosis survival, and shows low cytotoxicity toward human macrophages. Decarine inhibits HIV replication in acutely infected lymphocytes. Decarine can be used for the researches of inflammation, tuberculosis, and HIV infection .
|
-
-
- HY-N10877
-
-
-
- HY-N15730
-
-
-
- HY-N8374
-
-
-
- HY-N3497
-
-
-
- HY-N12495
-
-
-
- HY-N17359
-
-
-
- HY-N18247
-
-
-
- HY-N13841
-
-
-
- HY-N17005
-
-
-
- HY-N11725
-
|
|
Structural Classification
Microorganisms
Phenols
Polyphenols
Source Classification
|
Fc Receptor (FcR)
|
|
Phlorofucofuroeckol A is a FcεRI inhibitor with low cytotoxicity toward basophilic leukemia cells. Phlorofucofuroeckol A suppresses binding activity between IgE and FcεRI receptor. Phlorofucofuroeckol A inhibits histamine release from basophilic leukemia cells stimulated by IgE/anti-IgE or calcium ionophore A23187 (HY-N6687). Phlorofucofuroeckol A inhibits β-hexosaminidase release from basophilic leukemia cells stimulated by IgE/DNP-BSA. Phlorofucofuroeckol A can be used for the research of allergy disease .
|
-
-
- HY-N18316
-
-
-
- HY-N17896
-
|
|
Structural Classification
Lignans
Sapindaceae
Phenylpropanoids
Acer buergerianum Miq.
Plants
Source Classification
|
Tyrosinase
|
|
Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is a lignan compound and a melanogenesis inhibitor with low cytotoxicity. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside is isolable from the stem bark of Acer buergerianum (Acer buergerianum). Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside effectively inhibits the melanogenesis process in α-MSH (HY-P0252)-stimulated B16 melanoma cells. Pinoresinol-4-O-β-D-apiosyl-(1→2)β-D-glucoside exhibits extremely high safety towards normal cells, and serves as an ideal tool molecule for studying melanoma mechanisms and developing related whitening products .
|
-
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W713297
-
|
|
|
Moroxydine hydrochloride-d8 (ABOB hydrochloride-d8) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels [1][2][3].
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-149058
-
|
|
|
Azide
|
|
Neuraminidase-IN-13 (Compound 10) is a neuraminidase inhibitor with antiviral activity and low cytotoxicity. Neuraminidase-IN-13 significantly inhibits NDV infection of Vero cells by preventing the release of viral particles from infected cells . Neuraminidase-IN-13 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
| Cat. No. |
Product Name |
|
Classification |
-
- HY-148842
-
|
|
|
Cationic Lipids
Cationic Lipids
|
|
C14-4 is an ionizable lipid utilized for the synthesis of lipid nanoparticles (LNPs). C14-4 enhances mRNA delivery, enabling the effective transport of mRNA to primary human T cells, which in turn induces functional protein expression. C14-4 demonstrates high transfection efficiency while maintaining low cytotoxicity .
|
-
- HY-148172
-
|
|
|
Nucleoside Analogs
Adenosine
|
|
L-Fd4A is an adenine derivative. L-Fd4A has anti-human immunodeficiency virus (HIV) (EC50=1.5 μM) and anti-hepatitis B virus (HBV) (EC50=1.7 μM) activity. L-Fd4A has low cytotoxicity .
|
-
- HY-148170
-
|
|
|
Nucleoside Analogs
Uridine
|
|
L-I-OddU, a L-5'-halo- dioxolane nucleoside analogue, is a potent and selective anti-Epstein-Barr virus (EBV) agent with an EC50 value of 0.03μM. L-I-OddU has low cytotoxicity with a CC50 value of 1000 nM. L-I-OddU has antiviral activity by suppressing replicative EBV DNA and viral protein synthesis .
|
-
- HY-156087
-
|
|
|
Adjuvant
|
|
Cholicamideβ (GMP) is a GMP grade of Cholicamideβ. Cholicamideβ (compound 6) is a self-assembling, small molecule, cancer vaccine adjuvant. Cholicamideβ can form virus-like particles with low cytotoxicity. Cholicamideβ, upon binding to peptide antigens, enhances antigen presentation by dendritic cells and induces antigen-specific T cells. Cholicamideβ can induce apoptosis and necrosis .
|
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